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All Outputs (7)

Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors (2023)
Journal Article
Clennell, B., Steward, T. G., Hanman, K., Needham, T., Benachour, J., Jepson, M., …Whitcomb, D. J. (2023). Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors. Brain Stimulation, 16(2), https://doi.org/10.1016/j.brs.2023.01.1674

Background
Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision. However, the cellular and molecular consequences of ultrasound stimulation on neuron... Read More about Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors.

Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants (2022)
Journal Article
Sanders, B., D’Andrea, D., Collins, M. O., Rees, E., Steward, T. G., Zhu, Y., …Shin, E. (2022). Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature communications, 13, Article 27. https://doi.org/10.1038/s41467-021-27601-0

Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. Here we integrate human genetics with transcriptomic... Read More about Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.

Transient ultrasound stimulation has lasting effects on neuronal excitability (2021)
Journal Article
Clennell, B., Steward, T. G., Elley, M., Shin, E., Weston, M., Drinkwater, B. W., & Whitcomb, D. J. (2021). Transient ultrasound stimulation has lasting effects on neuronal excitability. Brain Stimulation, 14(2), 217-225. https://doi.org/10.1016/j.brs.2021.01.003

Background
Transcranial ultrasound stimulation can acutely modulate brain activity, but the lasting effects on neurons are unknown.

Objective
To assess the excitability profile of neurons in the hours following transient ultrasound stimulation.... Read More about Transient ultrasound stimulation has lasting effects on neuronal excitability.