All Outputs (5)

Microcalcification crystallography as a potential marker of DCIS recurrence (2023)
Journal Article
Gosling, S. B., Arnold, E. L., Davies, S. K., Cross, H., Bouybayoune, I., Calabrese, D., …van Oirsouw, M. (2023). Microcalcification crystallography as a potential marker of DCIS recurrence. Scientific reports, 13(1), Article 9331. https://doi.org/10.1038/s41598-023-33547-8

Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatm... Read More about Microcalcification crystallography as a potential marker of DCIS recurrence.

Thermally dynamic examination of local order in nanocrystalline hydroxyapatite (2022)
Journal Article
Arnold, E. L., Gosling, S., Davies, S. K., Cross, H. L., Evans, P., Keeble, D. S., …Rogers, K. D. (2022). Thermally dynamic examination of local order in nanocrystalline hydroxyapatite. Journal of Solid State Chemistry, 315, Article 123474. https://doi.org/10.1016/j.jssc.2022.123474

The main mineral component of bone is hydroxyapatite, a commonly nanocrystalline material which presents many challenges for those trying to characterize it. Here, local structure is analyzed using X-ray total scattering for synthetic samples, to ena... Read More about Thermally dynamic examination of local order in nanocrystalline hydroxyapatite.

A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications (2022)
Journal Article
Gosling, S., Calabrese, D., Nallala, J., Greenwood, C., Pinder, S., King, L., …Stone, N. (2022). A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications. Analyst, 147(8), 1641-1654. https://doi.org/10.1039/d1an01548f

Ductal carcinoma in situ (DCIS) is frequently associated with breast calcification. This study combines multiple analytical techniques to investigate the heterogeneity of these calcifications at the micrometre scale. X-ray diffraction, scanning elect... Read More about A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications.

Breast Microcalcifications - Novel Biomarkers for Breast Tissue Pathology (2019)
Journal Article
Gosling, S., Scott, R., Greenwood, C., Bouzy, P., Nallala, J., Lyburn, I., …Rogers, K. (2019). Breast Microcalcifications - Novel Biomarkers for Breast Tissue Pathology. Breast Cancer Research, 21(S1),

Microcalcifications are a key feature of mammography. Calcium phosphate (hydroxyapatite) microcalcifications are associated with both benign and malignant breast tissue and spectroscopic analysis has previously shown microstructure and chemistry vari... Read More about Breast Microcalcifications - Novel Biomarkers for Breast Tissue Pathology.

Calcification Microstructure Reflects Breast Tissue Microenvironment (2019)
Journal Article
Gosling, S., Scott, R., Greenwood, C., Bouzy, P., Nallala, J., D. Lyburn, I., …Rogers, K. (2019). Calcification Microstructure Reflects Breast Tissue Microenvironment. Journal of Mammary Gland Biology and Neoplasia, 333-342. https://doi.org/10.1007/s10911-019-09441-3

Microcalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. Hydroxyapatite microcalcific... Read More about Calcification Microstructure Reflects Breast Tissue Microenvironment.