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All Outputs (1101)

Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival (2024)
Thesis
Maroszek, M. R. Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/884975

Current research indicates that long noncoding RNAs orchestrate various regulatory processes in a physiological context and thereby, their dysregulation may contribute to major human diseases, including cancer (Grammatikakis et al.,2014).

Long no... Read More about Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival.

Applying electron microscopy analysis to assess neural tissue engineering outcomes (2024)
Thesis
Lindop, G. E. (2024). Applying electron microscopy analysis to assess neural tissue engineering outcomes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/884963

Spinal cord injury (SCI) has a major socio-economic impact with treatments providing little to no functional recovery due to the SCI environment hindering regeneration through chemical and physical barriers. Novel approaches to alter the injury envir... Read More about Applying electron microscopy analysis to assess neural tissue engineering outcomes.

Nebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial (2024)
Journal Article
Ramos da Silva Grillo, V. T., Bertanha, M., da Silva Rodrigues, L., de Lima, M. A., Mellucci Filho, P. L., Rahal Guaragna Machado, R., …Fortaleza, C. M. C. B. (in press). Nebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial. Scientific Reports, 14(1), Article 19902. https://doi.org/10.1038/s41598-024-70064-8

To evaluate the safety and the potential antiviral treatment of inhaled enriched heparin in patients with COVID-19. The specific objectives were to investigate the anticoagulation profile, antiviral and anti-inflammatory effects, and respiratory evol... Read More about Nebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial.

Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa (2024)
Journal Article
Li, X., Cheng, J., Han, H., Kirk, W. D., O’Brien, M., Wang, L., …Lu, Y. (in press). Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa. Journal of Chemical Ecology, https://doi.org/10.1007/s10886-024-01532-8

Odontothrips loti (Haliday) (Thysanoptera: Thripidae) is one of the most serious pests on alfalfa, causing direct damage by feeding and indirect damage by transmitting plant viruses. This damage causes significant loss in alfalfa production. Semioche... Read More about Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa.

High prevalence of multi-drug resistant bacteria in faecal samples from UK passerine birds (2024)
Journal Article
Dunn, J. C., & Clegg, S. R. (2024). High prevalence of multi-drug resistant bacteria in faecal samples from UK passerine birds. bioRxiv, https://doi.org/10.1101/2024.07.24.604896

Wild birds are a near ubiquitous sight in gardens, offering pleasure to many people through supplementary feeding, song, or other interactions. However, they are also potential carriers of many pathogens, including Campylobacter, Salmonella, Enteroco... Read More about High prevalence of multi-drug resistant bacteria in faecal samples from UK passerine birds.

Rabies control in Bangladesh and prediction of human rabies cases by 2030: a One Health approach (2024)
Journal Article
Ghosh, S., Hasan, M. N., Nath, N. D., Haider, N., Jones, D. H., Islam, M. K., …Islam, M. N. (2024). Rabies control in Bangladesh and prediction of human rabies cases by 2030: a One Health approach. The Lancet Regional Health - Southeast Asia, 27, Article 100452. https://doi.org/10.1016/j.lansea.2024.100452

Background
Bangladesh is making progress toward achieving zero dog-mediated rabies deaths by 2030, a global goal set in 2015.

Methods
Drawing from multiple da... Read More about Rabies control in Bangladesh and prediction of human rabies cases by 2030: a One Health approach.

Screening of an open-source compound library against the livestock parasite Trypanosoma evansi (2024)
Thesis
Ansah, M. L. K. (2024). Screening of an open-source compound library against the livestock parasite Trypanosoma evansi. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853242

Surra is a neglected tropical veterinary disease that causes a large socioeconomic burden in sub-Saharan Africa, South America, the middle east, Asia, and parts of Southern Europe. Although symptoms can be mild in wild animal species, disease in dome... Read More about Screening of an open-source compound library against the livestock parasite Trypanosoma evansi.

Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum (2024)
Thesis
Mobley, R. M. (2024). Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853179

Malaria continues to cause great global health concerns despite efforts for control and elimination. The emergence of resistance to components of the frontline artemisinin combination therapy highlights the urgent need for novel malaria therapeutics... Read More about Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum.

Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems (2024)
Thesis
Nascimento, C. L. D. (2024). Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853170

Vector-borne diseases are responsible for 17% of all infectious diseases worldwide and contribute to more than 700 000 deaths annually, mainly in sub-Saharan countries. Vector surveillance is a crucial element of vector control programmes to assure t... Read More about Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems.

Investigating multiple factors affecting the successful infection and transmission of arboviruses (2024)
Thesis
Widlake, E. (2024). Investigating multiple factors affecting the successful infection and transmission of arboviruses. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/850302

Arboviruses are arthropod-borne viruses that cycle between a vertebrate host and an arthropod vector. This disparate life cycle involves adapting to two alternate animals and the differing tissues and systems within them. A range of factors influence... Read More about Investigating multiple factors affecting the successful infection and transmission of arboviruses.

Developing genetic tools to control the Oriental fruit fly: Potential approaches and target genes (2024)
Journal Article
Traoré, N., Galizi, R., Kientega, M., Maïga, H., Nébié, K., Dabiré, R. A., …Diabaté, A. (in press). Developing genetic tools to control the Oriental fruit fly: Potential approaches and target genes. Journal of Applied Entomology, https://doi.org/10.1111/jen.13314

The Oriental fruit fly, Bactrocera dorsalis, is a pest of significant economic interest that damages horticulture and causes major economic losses worldwide. The main control measures are based on insecticides, which are being increasingly restricted... Read More about Developing genetic tools to control the Oriental fruit fly: Potential approaches and target genes.

Accessing active fragments for drug discovery utilising nitroreductase biocatalysis. (2024)
Journal Article
Holder, L., Yuce, E., Oriomah, G., Jenkins, A.-P., Reynisson, J., Winter, A., & Cosgrove, S. (in press). Accessing active fragments for drug discovery utilising nitroreductase biocatalysis. ChemBioChem, Article e202400428. https://doi.org/10.1002/cbic.202400428

Biocatalysis has played a limited role in the early stages of drug discovery. This is often attributed to the limited substrate scope of enzymes not affording access to vast areas of novel chemical space. Here, we have shown a promiscuous nitroreduct... Read More about Accessing active fragments for drug discovery utilising nitroreductase biocatalysis..

Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector. (2024)
Journal Article
Mapua, S. A., Samb, B., Nambunga, I. H., Mkandawile, G., Bwanaly, H., Kaindoa, E. W., …Tripet, F. (2024). Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector. Parasites and Vectors, 17(1), 1-10. https://doi.org/10.1186/s13071-024-06348-9

Malaria transmission in Tanzania is driven by mosquitoes of the Anopheles gambiae complex and Anopheles funestus group. The latter includes An. funestus s.s., an anthropophilic vector, which is now strongly resistant to public health insecticides, an... Read More about Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector..

International Biological Flora: Ceratonia siliqua (2024)
Journal Article
Thomas, P. A., Garcia‐Martí, X., Mukassabi, T. A., & Tous, J. (in press). International Biological Flora: Ceratonia siliqua. Journal of Ecology, https://doi.org/10.1111/1365-2745.14325

This account presents information on all aspects of the biology of Ceratonia siliqua L. (Carob) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of the Intern... Read More about International Biological Flora: Ceratonia siliqua.

Effect of cardiolipin on the lamellarity and elongation of liposomes hydrated in PBS (2024)
Journal Article
Piccinini, A., Kohlbrecher, J., Moussaoui, D., Winter, A., & Prévost, S. (in press). Effect of cardiolipin on the lamellarity and elongation of liposomes hydrated in PBS. Journal of Colloid and Interface Science, 669, 844-855. https://doi.org/10.1016/j.jcis.2024.04.211


Lamellarity and shape are important factors in the formation of vesicles and determine their role in biological systems and pharmaceutical applications. Cardiolipin (CL) is a major lipid in many biological membranes and exerts a gr... Read More about Effect of cardiolipin on the lamellarity and elongation of liposomes hydrated in PBS.

Identifying archived insect bulk samples using DNA metabarcoding: A case study using the long‐term Rothamsted Insect Survey (2024)
Journal Article
Petsopoulos, D., Cuff, J. P., Bell, J. R., Kitson, J. J. N., Collins, L., Boonham, N., …Evans, D. M. (2024). Identifying archived insect bulk samples using DNA metabarcoding: A case study using the long‐term Rothamsted Insect Survey. Environmental DNA, 6(3), e542. https://doi.org/10.1002/edn3.542

Insect populations are declining in many parts of the world, but a lack of long-term monitoring data is impeding our ability to understand and mitigate the causes of insect biodiversity loss. Whilst high-throughput sequencing (HTS) approaches, such a... Read More about Identifying archived insect bulk samples using DNA metabarcoding: A case study using the long‐term Rothamsted Insect Survey.

DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS (2024)
Working Paper
Ansumana, R., Bockarie, A. S., Konneh, M., Haider, N., Cadmus, E., Korvah, A., …Alders, R. DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS

Background Outbreaks of infectious diseases like Ebola virus disease, Lassa fever, and COVID-19 have severely strained infrastructural systems and social services across West Africa. We investigated the disruptions caused by emerging outbreaks on acc... Read More about DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS.

Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso (2024)
Journal Article
Traoré, N., Kientega, M., Maïga, H., Nebié, K., Zida, I., Galizi, R., …Diabaté, A. (2024). Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso. Insects, 15(5), Article 298. https://doi.org/10.3390/insects15050298

Bactrocera dorsalis Hendel is a highly invasive horticultural pest that is of major economic importance worldwide. In Burkina Faso, it is one of the main insect pests that affects the production and exportation of mangos. Understanding the biology an... Read More about Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso.

How aphids fly: take off, free flight and implications for short and long distance migration (2024)
Journal Article
Bell, J. R., & Shephard, G. (in press). How aphids fly: take off, free flight and implications for short and long distance migration. Agricultural and forest entomology, 1-10. https://doi.org/10.1111/afe.12623

An introduction to high‐speed photography and its entomological impact is provided, emphasizing the importance of high frame rates and high resolution. The take‐off and free flight of Drepanosiphum platanoidis and Myzus persicae were studied in still... Read More about How aphids fly: take off, free flight and implications for short and long distance migration.