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All Outputs (20153)

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H. S., Newell, K., Hopkins, T., …Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective
To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA).
Design
Ten million culture-expande... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

Exploring purchase intention in metaverse retailing: Insights from an automotive platform (2024)
Journal Article
Zhang, H., Lv, Y., Zhang, J. Z., Hollebeek, L. D., Behl, A., & Urbonavicius, S. (in press). Exploring purchase intention in metaverse retailing: Insights from an automotive platform. Journal of Retailing and Consumer Services, 82, Article 104144. https://doi.org/10.1016/j.jretconser.2024.104144

As an integration of cutting-edge digital technologies, the metaverse is set to revolutionize online retailing. This study employed a well-established metaverse automotive retailing platform in China to explore the paths influencing consumers' purcha... Read More about Exploring purchase intention in metaverse retailing: Insights from an automotive platform.

A person-centred primary care pharmacist-led osteoporosis review for optimising medicines (PHORM): a protocol for the development and co-design of a model consultation intervention (2024)
Journal Article
Sturrock, A., Grabrovaz, M., Bullock, L., Clark, E., Finch, T., Haining, S., …Paskins, Z. (2024). A person-centred primary care pharmacist-led osteoporosis review for optimising medicines (PHORM): a protocol for the development and co-design of a model consultation intervention. BMJ Open, 14(11), https://doi.org/10.1136/bmjopen-2024-085323

Introduction: Adherence to medicines in osteoporosis is poor, with estimated 1 year persistence rates between 16% and 60%. Poor adherence is complex, relating to combinations of fear of side effects, beliefs about medication being unnecessary, doubts... Read More about A person-centred primary care pharmacist-led osteoporosis review for optimising medicines (PHORM): a protocol for the development and co-design of a model consultation intervention.

Examining the role of adaptation in spontaneous perceptual reversals of ambiguous motion stimuli (2024)
Thesis
Dundas, K. Examining the role of adaptation in spontaneous perceptual reversals of ambiguous motion stimuli. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956391

The cause of spontaneous perceptual reversals of visually ambiguous stimuli has been attributed to several different mechanisms. One hypothesis suggests that adaptation, or “neural fatigue”, builds up while one interpretation is dominant and eventual... Read More about Examining the role of adaptation in spontaneous perceptual reversals of ambiguous motion stimuli.

‘More able’ pupils in non-selective secondary schools: a qualitative examination of teachers’ and pupils’ perceptions of progress (2024)
Thesis
Buckingham, P. E. ‘More able’ pupils in non-selective secondary schools: a qualitative examination of teachers’ and pupils’ perceptions of progress. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956384

This thesis explores the experiences of students labelled as ‘more able’, privileging the voices of pupils and practitioners equally. The research is conducted within a non-selective ‘comprehensive’ secondary school in England and argues that the cur... Read More about ‘More able’ pupils in non-selective secondary schools: a qualitative examination of teachers’ and pupils’ perceptions of progress.

Fundamental parameters of very low mass stars in eclipsing binary systems (2024)
Thesis
Fitzpatrick, E. Fundamental parameters of very low mass stars in eclipsing binary systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956373

Photometry of binary star and extrasolar planet transits offer an opportunity to characterise their components and test stellar models. When investigating exoplanets, it is important properly understand the host star otherwise large systematic errors... Read More about Fundamental parameters of very low mass stars in eclipsing binary systems.

Developing classification and regression based machine learning algorithms for bank loan approval and stock market prediction problems (2024)
Thesis
Mistry, K. A. J. Developing classification and regression based machine learning algorithms for bank loan approval and stock market prediction problems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956367

Developing machine learning (ML) algorithms to predict unseen data based on the trends of existing data has always been very challenging. Its technology demand to be applied to a wide range of problems is very high and is only expected to rise. Altho... Read More about Developing classification and regression based machine learning algorithms for bank loan approval and stock market prediction problems.

King Arthur in British Literature, 1660-1815 (2024)
Thesis
Blaney, A. L. King Arthur in British Literature, 1660-1815. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956346

This thesis explores the literary afterlives of the Arthurian legend across the long eighteenth century by examining the ways in which reworkings of Arthur intervene in debates about historiography, gender, class, and national identity.
Commencing... Read More about King Arthur in British Literature, 1660-1815.

Letters from home: an interpretive exploration of the experiences of people who were children during World War Two (2024)
Thesis
Longson, K. J. Letters from home: an interpretive exploration of the experiences of people who were children during World War Two. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956336

World War Two (WWII) brought upheaval for children on a global scale, with fathers conscripted and transported away to fight in sometimes distant places, mothers supporting the war effort and millions of children evacuated away from home and harm. Pe... Read More about Letters from home: an interpretive exploration of the experiences of people who were children during World War Two.

Trajectories of work absence in England due to a musculoskeletal or mental health condition: an electronic health record study (2024)
Thesis
Legha, A. S. Trajectories of work absence in England due to a musculoskeletal or mental health condition: an electronic health record study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956328

Introduction
Long-term sickness absence has recently been rising in the UK, causing a record number of economically inactive individuals and prompting concern from the Government. The aim of this thesis is to derive trajectories of absence over time... Read More about Trajectories of work absence in England due to a musculoskeletal or mental health condition: an electronic health record study.

Textile based medical devices and their role in sustainable health systems (2024)
Thesis
Morris, H. V. Textile based medical devices and their role in sustainable health systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956321

The field of medical textiles is one of the fastest growing areas within the technical textiles sector of the textile industry. Part of this expansion is because of advances in technology, such as nanotechnology, electrospinning, and the ability to i... Read More about Textile based medical devices and their role in sustainable health systems.

Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate (2024)
Thesis
Logan, S. J. Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956315

Background
Methotrexate is recommended as initial disease modifying anti-rheumatic drug (DMARD) therapy to treat Rheumatoid Arthritis (RA). Rheumatology nurses provide information in DMARD counselling consultations to support people to take treatme... Read More about Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate.

A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation (2024)
Journal Article
Orfanos, G., McCarthy, H. S., Williams, M., Dugard, N., Gallacher, P. D., Glover, A. W., …Kuiper, J. H. (2024). A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation. Cartilage, https://doi.org/10.1177/19476035241279943

Objective
Traditional autologous chondrocyte implantation (ACI) involves arthroscopically harvesting a cartilage biopsy (stage 1), followed by arthrotomy 3-4 weeks later to apply a periosteal patch and implant culture-expanded chondrocytes underneat... Read More about A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation.

Outcrop spectral gamma-ray signals of distal arid continental basins: Facies identification and controls (2024)
Journal Article
Pettigrew, R. P., Priddy, C. L., & Clarke, S. M. (2024). Outcrop spectral gamma-ray signals of distal arid continental basins: Facies identification and controls. Marine and Petroleum Geology, 168, Article 107047. https://doi.org/10.1016/j.marpetgeo.2024.107047

Spectral gamma ray (SGR) studies can help link outcrop exposures to downhole data and provide useful case studies to reduce uncertainty in interpreting geophysical logs where core and other geological data is unavailable. However, this technique is u... Read More about Outcrop spectral gamma-ray signals of distal arid continental basins: Facies identification and controls.

BioRxToolbox: A computational framework to streamline genetic circuit design in molecular data communications (2024)
Journal Article
Gorkem Durmaz, M., Tulluk, N., Aksoy, R. D., Birkan Yilmaz, H., Yang, B., Wipat, A., …Tugcu, T. (in press). BioRxToolbox: A computational framework to streamline genetic circuit design in molecular data communications. Synthetic Biology, https://doi.org/10.1093/synbio/ysae015

Developments in bioengineering and nanotechnology have ignited the research on biological and molecular communication systems. Despite potential benefits, engineering communication systems to carry data signals using biological messenger molecules an... Read More about BioRxToolbox: A computational framework to streamline genetic circuit design in molecular data communications.

ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells (2024)
Journal Article
Cortella, G., Lamparelli, E. P., Ciardulli, M. C., Lovecchio, J., Giordano, E., Maffulli, N., & Della Porta, G. (in press). ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells. Bioengineering and Translational Medicine, 1-15. https://doi.org/10.1002/btm2.10723

The advent of bioprinting has enabled the creation of precise three‐dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) comb... Read More about ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.

Immediate Versus Staged Complete Revascularization for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Disease: A Network Meta‐Analysis of Randomized Trials (2024)
Journal Article
Elbadawi, A., Hamed, M., Gad, M., Elseidy, S. A., Barghout, M., Jneid, H., …Elgendy, I. Y. (in press). Immediate Versus Staged Complete Revascularization for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Disease: A Network Meta‐Analysis of Randomized Trials. Journal of the American Heart Association, 13(21), https://doi.org/10.1161/jaha.124.035535

Background The comparative outcomes with immediate, staged in‐hospital, and staged out‐of‐hospital complete revascularization for patients with ST‐segment–elevation myocardial infarction and multivessel disease remain unclear. Methods and Results An... Read More about Immediate Versus Staged Complete Revascularization for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Disease: A Network Meta‐Analysis of Randomized Trials.

Evaluating the Performance Resilience of Serverless Applications using Chaos Engineering (2024)
Conference Proceeding
Zayed, A., & Al-Said Ahmad, A. (2024). Evaluating the Performance Resilience of Serverless Applications using Chaos Engineering. . https://doi.org/10.1109/qrs-c63300.2024.00172

This study explores the use of chaos engineering in evaluating the performance and resilience of serverless applications, which are built as complex distributed systems subject to different types of failures and errors. By intentionally injecting con... Read More about Evaluating the Performance Resilience of Serverless Applications using Chaos Engineering.

Myocardial infarction risk across cancer subtypes - nationwide registry study (2024)
Journal Article
Shanmuganathan, J., Jacobsen, P. A. J., Schou, M. S., Torp Pedersen, C. T. P., Poulsen, L., Polcwiartek, C. B. P., …Kragholm, K. K. (2024). Myocardial infarction risk across cancer subtypes - nationwide registry study. European Heart Journal, 45(Supplement_1), https://doi.org/10.1093/eurheartj/ehae666.1551

Background Progress in cancer treatments have significantly improved patient outcomes, leading to increased survival rates. However, patients with cancer continue to have higher rates of cardiovascular events an area that has traditionally not receiv... Read More about Myocardial infarction risk across cancer subtypes - nationwide registry study.

Addressing disparities in the long-term mortality of non-ST segment myocardial infarction (NSTEMI) patients according to the presence of diabetes mellitus: a nationwide cohort study (2024)
Journal Article
Cole, A., Weight, N., Mishra, S., Grapsa, J., Rutter, M., Siudak, Z., …Mamas, M. (2024). Addressing disparities in the long-term mortality of non-ST segment myocardial infarction (NSTEMI) patients according to the presence of diabetes mellitus: a nationwide cohort study. European Heart Journal, 45(Supplement_1), https://doi.org/10.1093/eurheartj/ehae666.1533

Background Diabetes mellitus (DM) is an important risk factor for non−ST segment elevation myocardial infarction (NSTEMI). How DM is related to management and longer-term clinical outcomes in contemporary NSTEMI cohorts is not well described. Methods... Read More about Addressing disparities in the long-term mortality of non-ST segment myocardial infarction (NSTEMI) patients according to the presence of diabetes mellitus: a nationwide cohort study.