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Professor Wim Cool's Outputs (9)

PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS (2023)
Journal Article
Wilkinson, H., & Cool, P. (2023). PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS. Orthopaedic Proceedings, 105-B(SUPP_16), 43-43. https://doi.org/10.1302/1358-992x.2023.16.043

AbstractObjectivesThe objective of this study is to investigate if genomic sequencing is a useful method to diagnose orthopaedic infections. Current methods used to identify the species of bacteria causing orthopaedic infections take considerable tim... Read More about PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS.

Aneurysmal bone cysts: A UK wide tumor center experience (2023)
Journal Article
Bavan, L., Eastley, N., Stevenson, J., Mifsud, M., Bayliss, L., Mahmoud, S., …Kothari, A. (in press). Aneurysmal bone cysts: A UK wide tumor center experience. Journal of Surgical Oncology, 129(3), 601-608. https://doi.org/10.1002/jso.27499

Background and Objectives
This multicenter retrospective series of consecutive extra-spinal aneurysmal bone cysts aims to identify risk factors for treatment failure.

Methods
Aneurysmal bone cysts treated within seven collaborating centers with... Read More about Aneurysmal bone cysts: A UK wide tumor center experience.

Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy (2023)
Journal Article
Bentick, K., Runevic, J., Akula, S., Kyriacou, T., Cool, P., & Andras, P. (2023). Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy. Methods, 220, 55-60. https://doi.org/10.1016/j.ymeth.2023.10.012

This study explores the possibility of using routinely taken blood tests in the diagnosis and triage of patients with suspected musculoskeletal malignancy. A retrospective study was performed on results of patients who had presented for assessment to... Read More about Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy.

The British Orthopaedic Oncology Management (BOOM) audit (2023)
Journal Article
Archer, J. E., Chauhan, G. S., Dewan, V., Osman, K., Thomson, C., Nandra, R. S., …Stevenson, J. (2023). The British Orthopaedic Oncology Management (BOOM) audit. The Bone & Joint Journal, 105-B(10), 1115-1122. https://doi.org/10.1302/0301-620x.105b10.bjj-2023-0443.r1

AimsMost patients with advanced malignancy suffer bone metastases, which pose a significant challenge to orthopaedic services and burden to the health economy. This study aimed to assess adherence to the British Orthopaedic Oncology Society (BOOS)/Br... Read More about The British Orthopaedic Oncology Management (BOOM) audit.

Clinical outcome of open ankle fractures in patients above 70 years of age (2023)
Journal Article
Zahra, W., Seifo, M., Cool, P., Ford, D., & Okoro, T. (2023). Clinical outcome of open ankle fractures in patients above 70 years of age. World Journal of Orthopedics, 14(7), 554-561. https://doi.org/10.5312/wjo.v14.i7.554

Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older tha... Read More about Clinical outcome of open ankle fractures in patients above 70 years of age.

Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report (2023)
Journal Article
Wilkinson, H., McCarthy, H. S., Perry, J., Smith, T., Wright, K., & Cool, P. (2023). Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report. Cureus, 15(5), https://doi.org/10.7759/cureus.38788

There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial... Read More about Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.

Umbilical Cord MSC Treated Osteoarthritic Sheep Display Reduced Radiographic Changes: Proteomic Biomarker Profiling of Synovial Fluids Implicate an Immunomodulatory Mechanism (2023)
Presentation / Conference
Perry, J., Mennan, C., Cool, P., Mccarthy, H., Newell, K., Hulme, C., …Roberts, S. (2023, March). Umbilical Cord MSC Treated Osteoarthritic Sheep Display Reduced Radiographic Changes: Proteomic Biomarker Profiling of Synovial Fluids Implicate an Immunomodulatory Mechanism. Presented at TERMIS 2023 – European Chapter, Manchester Central Conference Centre Manchester, UK

pTERT mutation in the risk-stratification of solitary fibrous tumours (2023)
Presentation / Conference
Butters, T., Andrei, V., Hepburn, E., Connolly, C., Mendes, B., Haefliger, S., …Flanagan, A. (2023, January). pTERT mutation in the risk-stratification of solitary fibrous tumours. Presented at WINTER MEETING, 5th Joint Meeting with the Royal Society of Medicine, 214th Scientific Meeting of the Pathological Society of Great Britain & Ireland, Royal Society of Medicine, London

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Pages: S1-S4