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Alastair Channon's Outputs (2)

Where antibiotic resistance mutations meet quorum-sensing (2014)
Journal Article
Channon. (2014). Where antibiotic resistance mutations meet quorum-sensing. Microbial Cell, 250 - 252. https://doi.org/10.15698/mic2014.07.158

We do not need to rehearse the grim story of the global rise of antibiotic resistant microbes. But what if it were possible to control the rate with which antibiotic resistance evolves by de novo mutation? It seems that some bacteria may already do e... Read More about Where antibiotic resistance mutations meet quorum-sensing.

Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell-cell interactions (2014)
Journal Article
Channon, A. (2014). Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell-cell interactions. Nature communications, 3742 -?. https://doi.org/10.1038/ncomms4742

Variation of mutation rate at a particular site in a particular genotype, in other words mutation rate plasticity (MRP), can be caused by stress or ageing. However, mutation rate control by other factors is less well characterized. Here we show that... Read More about Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell-cell interactions.