Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions (2021)
Journal Article
Barnes, N. G., Ahmed Mal Ullah, A. A., Ragazzon, P. A., Charafi, N., & Hadfield, J. A. (2021). Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions. ChemistrySelect, 6(28), 7082 - 7086. https://doi.org/10.1002/slct.202101960

Combretastatin A-4 (CA4) is a potent anti-mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions.

Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents (2019)
Journal Article
McGown, A., Ragazzon-Smith, A., Hadfield, J. A., Potgetier, H., & Ragazzon, P. A. (2019). Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents. Letters in Organic Chemistry, 16(1), 66-75. https://doi.org/10.2174/1570178615666180621094529

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized an... Read More about Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents.