Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis (2022)
Journal Article
Cosgrove, Miller, & Dolan. (2022). Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis. JACS Au, 47-61. https://doi.org/10.1021/jacsau.2c00529

While the field of biocatalysis has bloomed over the past 20–30 years, advances in the understanding and improvement of carbohydrate-active enzymes, in particular, the sugar nucleotides involved in glycan building block biosynthesis, have progressed... Read More about Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis.

Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. (2022)
Journal Article
Cosgrove, S. C., & Miller, G. J. (2022). Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. Expert Opinion on Drug Discovery, 17(4), 355-364. https://doi.org/10.1080/17460441.2022.2039620

INTRODUCTION: Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery over the last 60 years. Traditionally accessed using chemical synthesis... Read More about Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues..

Oxidase enzymes as sustainable oxidation catalysts (2022)
Journal Article
Wahart, A. J. C., Staniland, J., Miller, G. J., & Cosgrove, S. C. (2022). Oxidase enzymes as sustainable oxidation catalysts. Royal Society Open Science, 9(1), https://doi.org/10.1098/rsos.211572

Oxidation is one of the most important processes used by the chemical industry. However, many of the methods that are used pose significant sustainability and environmental issues. Biocatalytic oxidation offers an alternative to these methods, with a... Read More about Oxidase enzymes as sustainable oxidation catalysts.

Reaching new biocatalytic reactivity using continuous flow reactors (2021)
Journal Article
Cosgrove, S. C., & Mattey, A. P. (2022). Reaching new biocatalytic reactivity using continuous flow reactors. Chemistry - A European Journal, 28(13), https://doi.org/10.1002/chem.202103607

The use of flow reactors in biocatalysis has increased significantly in recent years. Chemists have begun to design flow systems that even allow new biocatalytic reactions to take place. This concept article will focus on the design of flow systems t... Read More about Reaching new biocatalytic reactivity using continuous flow reactors.

Enzyme immobilisation on wood-derived cellulose scaffolds via carbohydrate-binding module fusion constructs (2021)
Journal Article
Cosgrove. (2021). Enzyme immobilisation on wood-derived cellulose scaffolds via carbohydrate-binding module fusion constructs. Green Chemistry, 4716-4732. https://doi.org/10.1039/d1gc01008e

Enzyme-CBM fusion constructs immobilised on wood-derived cellulose scaffolds: a sustainable approach for continuous flow biocatalysis

Development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades. (2021)
Journal Article
Mattey, A. P., Ford, G. J., Citoler, J., Baldwin, C., Marshall, J. R., Palmer, R. B., …Flitsch, S. L. (2021). Development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades. Angewandte Chemie International Edition, 60(34), 18660-18665. https://doi.org/10.1002/anie.202103805

A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out multistep cascades in a controlled and selective way. As biocatalytic cascades get more complex, reactions become unattainable under typical batch conditions. Here a n... Read More about Development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades..

Production of High Value Amine Intermediates via Biocatalytic Cascades in Continuous Flow (2021)
Journal Article
Baldwin, C., Thompson, M., Turner, N., Pamer, R., Ford, G., Citoler, J., …Cosgrove, S. (2021). Production of High Value Amine Intermediates via Biocatalytic Cascades in Continuous Flow. ChemRxiv, https://doi.org/10.26434/chemrxiv.14039141.v1

<jats:p>A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out compartmentalized multistep cascades in a controlled and selective way. As biocatalytic cascades get longer and more complex, reactions become unattainable und... Read More about Production of High Value Amine Intermediates via Biocatalytic Cascades in Continuous Flow.

One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation. (2020)
Journal Article
Cosgrove. (2020). One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation. Angewandte Chemie, 18156 - 18160. https://doi.org/10.1002/anie.202006246

The combination of biocatalysis and chemo-catalysis increasingly offers chemists access to more diverse chemical architectures. Here, we describe the combination of a toolbox of chiral-amine-producing biocatalysts with a Buchwald-Hartwig cross-coupli... Read More about One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation..