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Synthesis of S-Glycoside Building Blocks as Mimetics of the Repeating d-GlcN-α-1,4-d-GlcA Heparan Sulfate Disaccharide (2024)
Journal Article
O’Shea, C., & Miller, G. J. (2024). Synthesis of S-Glycoside Building Blocks as Mimetics of the Repeating d-GlcN-α-1,4-d-GlcA Heparan Sulfate Disaccharide. Molecules, 29(23), Article 5809. https://doi.org/10.3390/molecules29235809

Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and extracellular matrix, is a key regulator of biological processes. Owing to the inherent structural complexity of HS, structure-to-function studies with its ligan... Read More about Synthesis of S-Glycoside Building Blocks as Mimetics of the Repeating d-GlcN-α-1,4-d-GlcA Heparan Sulfate Disaccharide.

Exploring the full range of N⋯I⋯X halogen-bonding interactions within a single compound using pressure † (2024)
Journal Article
Jones, R. H., Bull, C. L., Funnell, N. P., Knight, K. S., & Marshall, W. G. (in press). Exploring the full range of N⋯I⋯X halogen-bonding interactions within a single compound using pressure †. Chemical Communications, https://doi.org/10.1039/D4CC00847B

The response of the trimethylammonium–iodinechloride and diiodide (TMA–ICl/I2) crystal structures have been examined under high pressure using neutron powder diffraction. TMA–ICl exhibits impressive pressure-driven electronic flexibility, where the N... Read More about Exploring the full range of N⋯I⋯X halogen-bonding interactions within a single compound using pressure †.

Sustainable supercapacitor with a natural rubber-based electrolyte and natural graphite-based electrodes (2023)
Journal Article
Perera, K., Vidanapathirana, K., Adams, L. J., & Balakrishnan, N. (2023). Sustainable supercapacitor with a natural rubber-based electrolyte and natural graphite-based electrodes. Electrochemical Science Advances, Article e2300025. https://doi.org/10.1002/elsa.202300025

Supercapacitors are at the forefront of energy storage devices due to their ability to fulfill quick power requirements. However, safety and cost are important parameters for their real-world applications. Green materials-based electrodes and electro... Read More about Sustainable supercapacitor with a natural rubber-based electrolyte and natural graphite-based electrodes.

Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines (2023)
Journal Article
van Beek, C. M., Swarbrook, A. M., Creissen, C. E., Hawes, C. S., Gazis, T. A., & Matthews, P. D. (2023). Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines. Chemistry - A European Journal, 30(8), Article e202301944. https://doi.org/10.1002/chem.202301944

Boron‐ and nitrogen‐doped polycyclic aromatic hydrocarbons (B‐PAHs) have established a strong foothold in the realm of organic electronics. However, their catalytic potential remains largely untapped. In this study, we synthesise and characterise two... Read More about Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines.

Magnesium oxide loaded mesoporous silica: Synthesis, characterisation and use in removing lead and cadmium from water supplies (2023)
Journal Article
Saod, W., Oliver, I., Thompson, D., Holborn, S., Contini, A., Zholobenko, V., & Zholobenko, V. (2023). Magnesium oxide loaded mesoporous silica: Synthesis, characterisation and use in removing lead and cadmium from water supplies. Environmental Nanotechnology, Monitoring & Management, https://doi.org/10.1016/j.enmm.2023.100817

Water pollution by potentially toxic elements such as cadmium (Cd) and lead (Pb) is a persistent problem in many parts of the world. It continues to have profound implications for drinking water supplies, wastewater discharge and environmental qualit... Read More about Magnesium oxide loaded mesoporous silica: Synthesis, characterisation and use in removing lead and cadmium from water supplies.

Supramolecular Polymer Polymorphism: Spontaneous Helix-Helicoid Transition through Dislocation of Hydrogen-Bonded π-Rosettes. (2023)
Journal Article
Otsuka, C., Takahashi, S., Isobe, A., Saito, T., Aizawa, T., Tsuchida, R., …Hollamby, M. J. (2023). Supramolecular Polymer Polymorphism: Spontaneous Helix-Helicoid Transition through Dislocation of Hydrogen-Bonded π-Rosettes. Journal of the American Chemical Society, 145(41), 22563-22576. https://doi.org/10.1021/jacs.3c07556

Polymorphism, a phenomenon whereby disparate self-assembled products can be formed from identical molecules, has incited interest in the field of supramolecular polymers. Conventionally, the monomers that constitute supramolecular polymers are engine... Read More about Supramolecular Polymer Polymorphism: Spontaneous Helix-Helicoid Transition through Dislocation of Hydrogen-Bonded π-Rosettes..

Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents † (2023)
Journal Article
Wittmann, C., Dömötör, O., Kuznetcova, I., Spengler, G., Reynisson, J., Holder, L., …Arion, V. B. (2023). Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents †. Dalton Transactions, 52(29), 9964-9982. https://doi.org/10.1039/d3dt01632c

A series of four indolo[2,3-e]benzazocines HL1–HL4 and two indolo[2,3-f]benzazonines HL5 and HL6, as well as their respective copper(ii) complexes 1–6, were synthesized and characterized by 1H and 13C NMR spectroscopy, ESI mass spectrometry, single c... Read More about Indolo[2,3- e ]benzazocines and indolo[2,3- f ]benzazonines and their copper( ii ) complexes as microtubule destabilizing agents †.

Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. (2023)
Journal Article
Turnbull, J. (2023). Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. Glia, 71(7), 1683-1698. https://doi.org/10.1002/glia.24363

There is an urgent need for therapies that target the multicellular pathology of central nervous system (CNS) disease. Modified, nonanticoagulant heparins mimic the heparan sulfate glycan family and are known regulators of multiple cellular processes... Read More about Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination..

‘Rough Critical Winds’: Mis-selling English Pastoral in H. E. Bates’s Larkin Novels, 1958-1970’ (2023)
Journal Article
Shears. (2023). ‘Rough Critical Winds’: Mis-selling English Pastoral in H. E. Bates’s Larkin Novels, 1958-1970’. English Studies, 104(5), https://doi.org/10.1080/0013838X.2023.2188806

The revival of interest in H. E. Bates has largely come without much attention being paid to his series of five novels featuring the Larkin family (1958-1970). The neglect is because of their populist and comic mode. Yet, study of the Larkin novels e... Read More about ‘Rough Critical Winds’: Mis-selling English Pastoral in H. E. Bates’s Larkin Novels, 1958-1970’.

Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes (2023)
Journal Article
Hegarty, I. N., Hawes, C. S., & Gunnlaugsson, T. (2023). Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes. Organic Chemistry Frontiers, 10(8), 1915-1926. https://doi.org/10.1039/D3QO00232B

The synthesis of chiral a-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands 4-6 designed by combining the coordination properties of two well-known ligand structures within a single unit is described. The self-assembly formation bet... Read More about Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes.

Fine-tuning of the size of supramolecular nanotoroids suppresses the subsequent catenation of nano-[2]catenane (2023)
Journal Article
Itabashi, H., Datta, S., Tsukuda, R., Hollamby, M. J., & Yagai, S. (2023). Fine-tuning of the size of supramolecular nanotoroids suppresses the subsequent catenation of nano-[2]catenane. Chemical Science, 14(12), 3270 - 3276. https://doi.org/10.1039/D2SC07063D

A judicious combination of ring-closing supramolecular polymerization and secondary nucleation can hierarchically organize a diphenylnaphthalene barbiturate monomer bearing a 3,4,5-tri(dodecyloxy)benzyloxy unit into self-assembled nano-polycatenanes... Read More about Fine-tuning of the size of supramolecular nanotoroids suppresses the subsequent catenation of nano-[2]catenane.

Colloidal III-V quantum dots: a synthetic perspective (2023)
Journal Article
Gazis, T. A., Cartlidge, A. J., & Matthews, P. D. (2023). Colloidal III-V quantum dots: a synthetic perspective. Journal of Materials Chemistry C, 11(12), 3926-3935. https://doi.org/10.1039/d2tc05234b

With the advent of stricter environmental regulation, quantum dots based on cadmium, lead and other heavy metals have become anathema. III–V semiconductors constitute a promising alternative because they not only match but indeed surpass the optoelec... Read More about Colloidal III-V quantum dots: a synthetic perspective.

Environmental Applications of Zeolites: Hydrophobic Sn-BEA as a Selective Gas Sensor for Exhaust Fumes (2023)
Journal Article
Dubray, F., Jendrlin, M., Grand, J., Lakiss, L., El Fallah, J., Mintova, S., …Zholobenko, V. (2023). Environmental Applications of Zeolites: Hydrophobic Sn-BEA as a Selective Gas Sensor for Exhaust Fumes. Chemistry, 334 - 347. https://doi.org/10.3390/chemistry5010025

Environmental monitoring of pollutants, such as NOx and COx, which can be facilitated by a range of gas sensors, is of considerable fundamental and practical importance. This work has been focused on the synthesis and evaluation of zeolite beta with... Read More about Environmental Applications of Zeolites: Hydrophobic Sn-BEA as a Selective Gas Sensor for Exhaust Fumes.

Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. (2023)
Journal Article
Devlin, A. J., Mycroft-West, C. J., Turnbull, J. E., Andrade De Lima, M., Guerrini, M., Yates, E. A., & Skidmore, M. A. (2023). Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. ACS Central Science, 9, 381-392. https://doi.org/10.1021/acscentsci.2c01176

Heparin is a polydisperse, heterogeneous polysaccharide of the glycosaminoglycan (GAG) class that has found widespread clinical use as a potent anticoagulant and is classified as an essential medicine by the World Health Organization. The importance... Read More about Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State..

High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. (2023)
Journal Article
Maciej-Hulme, M. L., Leprince, A. C., Lavin, A., Guimond, S. E., Turnbull, J. E., Pelletier, J., …Skidmore, M. A. (2023). High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. Analytical Methods, 15(11), 1461-1469. https://doi.org/10.1039/d2ay01803a

The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in... Read More about High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts..

Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors (2023)
Journal Article
Clennell, B., Steward, T. G., Hanman, K., Needham, T., Benachour, J., Jepson, M., …Whitcomb, D. J. (2023). Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors. Brain Stimulation, 16(2), https://doi.org/10.1016/j.brs.2023.01.1674

Background
Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision. However, the cellular and molecular consequences of ultrasound stimulation on neuron... Read More about Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors.

A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1). (2023)
Journal Article
Mycroft-West, C., Devlin, A., Cooper, L., Guimond, S., Procter, P., Miller, G., …Skidmore, M. (2023). A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1). Carbohydrate Research, 525, Article 108747. https://doi.org/10.1016/j.carres.2023.108747

The clinically important anticoagulant heparin, a member of the glycosaminoglycan family of carbohydrates that is extracted predominantly from porcine and bovine tissue sources, has previously been shown to inhibit the ß-site amyloid precursor protei... Read More about A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1)..

Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose. (2023)
Journal Article
Porter, J., Lima, M. A., Pongener, I., & Miller, G. (2023). Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose. Carbohydrate Research, 524, Article 108759. https://doi.org/10.1016/j.carres.2023.108759

Sulfur containing glycosides offer an exciting prospect for inclusion within noncanonical glycan sequences, particularly as enabling probes for chemical glycobiology and for carbohydrate-based therapeutic development. In this context, we required acc... Read More about Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose..

Geographical Variation of Cuticular Hydrocarbon Profiles of Adult Flies and Empty Puparia Amongst Three Populations of Calliphora vicina (Diptera: Calliphoridae). (2023)
Journal Article
Kula, C., Amendt, J., Drijfhout, F., & Moore, H. (2023). Geographical Variation of Cuticular Hydrocarbon Profiles of Adult Flies and Empty Puparia Amongst Three Populations of Calliphora vicina (Diptera: Calliphoridae). Journal of Medical Entomology, 14 - 23. https://doi.org/10.1093/jme/tjac167

Blowflies (Diptera: Calliphoridae) are of great importance in forensic entomology and in determining the minimum post-mortem interval, as they may be the first group of insects to colonize decomposing remains. Reliable species identification is an es... Read More about Geographical Variation of Cuticular Hydrocarbon Profiles of Adult Flies and Empty Puparia Amongst Three Populations of Calliphora vicina (Diptera: Calliphoridae)..