Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy (2024)
Thesis
Dugmore, S. K. Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/1012545

In recent years, in many fields of scientific research, the multi-technique approach has grown into a robust method for the experimental characterisation of complex materials. The combination of diffraction, spectroscopy and other non-destructive tec... Read More about Understanding chromotropic materials with combined insitu Neutron Diffraction and Raman Spectroscopy.

Structural and ion exchange study of nanostructured materials (2024)
Thesis
Contini, A. (2024). Structural and ion exchange study of nanostructured materials. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/857282

In this thesis, the structural and acidic properties of two zeolites LTL and MAZ are compared and reported. Commercial LTL and MAZ were ion exchanged with metal alkali cations, to obtain the corresponding ion exchanged forms, and characterised by IR... Read More about Structural and ion exchange study of nanostructured materials.

Chemical synthesis approaches to amphiphilic mimetic glycosides (2024)
Thesis
Porter, J. A. (2024). Chemical synthesis approaches to amphiphilic mimetic glycosides. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/849924

The majority of surfactants in use are derived from petroleum feedstocks. Synthetic surfactants face numerous issues including low biodegradability, ecotoxicity and bioaccumulation. Biosurfactants such as amphiphilic glycoconjugates are a promising c... Read More about Chemical synthesis approaches to amphiphilic mimetic glycosides.

Evaluation of chemometric software for analysis of complex mixtures for biologically derived samples analysed using liquid-chromatography mass spectrometry (2024)
Thesis
Scott, M. R. (2024). Evaluation of chemometric software for analysis of complex mixtures for biologically derived samples analysed using liquid-chromatography mass spectrometry. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/850250

There is a risk of losing important information when choosing the best metabolomic workflow for untargeted chemometric analysis. Choosing the best software for conducting this analysis is crucial as wrong parameters with the wrong software could lead... Read More about Evaluation of chemometric software for analysis of complex mixtures for biologically derived samples analysed using liquid-chromatography mass spectrometry.

Bioprocess development for aliphatic alcohol oxidation and alkyl glycoside purification using biocatalysis (2024)
Thesis
Wahart, A. J. C. (2024). Bioprocess development for aliphatic alcohol oxidation and alkyl glycoside purification using biocatalysis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853204

The detergents and skin care products are composed of surfactants that decrease interfacial tension between two phases (i.e. oil and water).1 Before the ecological dangers issued from nonrenewable sources surfactants (pollution of aqueous environment... Read More about Bioprocess development for aliphatic alcohol oxidation and alkyl glycoside purification using biocatalysis.

Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles (2024)
Thesis
Latham-Wheawall, L. (2024). Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775441

The need for clean energy is not being met and is increasing each day. One immensely underused technology – proton exchange membrane fuel cells, can drastically help to deliver green energy and prevent the worsening of climate change. However, in ord... Read More about Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles.

Using the solid injection technique with gas chromatography and mass spectrometry to identify cuticular hydrocarbons in several thrips insect species (2023)
Thesis
Covaci, A. (2023). Using the solid injection technique with gas chromatography and mass spectrometry to identify cuticular hydrocarbons in several thrips insect species. (Thesis). Keele University

Thrips are a group of insects included in the order Thysanoptera. So far, over 6000 species have been described, among which over 100 are known as crop pests There is a plethora of studies on various species of thrips, yet the CHC composition is know... Read More about Using the solid injection technique with gas chromatography and mass spectrometry to identify cuticular hydrocarbons in several thrips insect species.

The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry (2023)
Thesis
Williams, M. F. (2023). The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry. (Thesis). Keele University

Statistics show that there was a 12% increase in missing persons’ incidents in the UK between 2014 and 2019. Approximately 50% of these missing individuals are found within 24 hours, and on average a large number will be deceased. Land-based searches... Read More about The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry.

ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control (2023)
Thesis
Devlin, A. J. (2023). ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control. (Thesis). Keele University

Heparin is a member of the glycosaminoglycan (GAG) family of naturally occurring, polydisperse, linear polysaccharides. Heparin is a ubiquitous anticoagulant drug, a member of the WHO’s list of vital medicines and the second used drug by weight after... Read More about ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control.

Chemical synthesis of fluorinated carbocyclic nucleoside analogues (2023)
Thesis
Benckendorff, C. M. M. (2023). Chemical synthesis of fluorinated carbocyclic nucleoside analogues. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/529473

Since the discovery of their pharmaceutical potential, nucleoside analogues have become one of the most important classes of chemotherapeutic agents in the treatment of many cancers and viral infections. In many chronic illnesses, such as HBV or HIV... Read More about Chemical synthesis of fluorinated carbocyclic nucleoside analogues.

Non-aromatic building blocks for metallosupramolecular assemblies (2023)
Thesis
Slyusarchuk, V. (2023). Non-aromatic building blocks for metallosupramolecular assemblies. (Thesis). Keele University

This study investigates the metallosupramolecular chemistry of coordinating ligands that contain a rigid aliphatic unit via the study of their coordination complexes when combined with d- and f-block metal ions. The aim was to investigate whether the... Read More about Non-aromatic building blocks for metallosupramolecular assemblies.

Investigating the interaction between dengue viral envelope proteins and host receptor molecules (2022)
Thesis
Hyatt, J. G. (2022). Investigating the interaction between dengue viral envelope proteins and host receptor molecules. (Thesis). Keele University

Infection of dengue remains to this date a major socio-economic and public health challenge for large parts of the world, especially low- and middle- income countries in the tropics and sub-tropics. Despite the prevalence of the associated neglected... Read More about Investigating the interaction between dengue viral envelope proteins and host receptor molecules.

Nanostructured materials for sensor applications (2022)
Thesis
Jendrlin, M. (2022). Nanostructured materials for sensor applications. (Thesis). Keele University

The utilisation of zeolites as infrared spectroscopy-based gas sensors and as potentiometric sensors in zeolite modified electrodes is reported in this thesis.
Commercial zeolites (NaX, NaY, MOR, FER, BEA-12, BEA-19 and ZSM-5) and prepared Sn-BEA ze... Read More about Nanostructured materials for sensor applications.

Chemical synthesis and biological evaluation of 4'-thionucleosides (2022)
Thesis
Guinan, M. (2022). Chemical synthesis and biological evaluation of 4'-thionucleosides. (Thesis). Keele University

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers and viruses. Several such compounds, including Sofosbuvir and Gemcitabine are the go-to option in first line treatments. Ho... Read More about Chemical synthesis and biological evaluation of 4'-thionucleosides.

Preparation and structural studies of halogen bonded co-crystals (2021)
Thesis
Mahmood, A. S. M. (2021). Preparation and structural studies of halogen bonded co-crystals. (Thesis). Keele University

The project investigates the reactions of selected aromatic nitrogen compounds with selected di- and interhalogens in order to obtain crystalline N···I halogen-bonded complexes according to the equation:
A + B ? AB

where reactant A is a pyridine... Read More about Preparation and structural studies of halogen bonded co-crystals.

Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes (2021)
Thesis
Bhunia, S. (2021). Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes. (Thesis). Keele University

The fetal membrane surrounds and supports the developing fetus during the pregnancy. The cellular structure of the fetal membrane and the proteins synthesized by the cells of amniotic and chorionic membranes, maintain the mechanical integrity of the... Read More about Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes.

Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa (2020)
Thesis
Beswick, L. E. M. (2020). Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa. (Thesis). Keele University

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterium, responsible for causing life threatening infections amongst fibrosis (CF) patients. Mucoid phenotypes of P. aeruginosa are characterised by overproduction of alginate, an extra-cel... Read More about Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa.

Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates (2020)
Thesis
Dimitriou, E. (2020). Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates. (Thesis). Keele University

Alginate is an anionic polysaccharide comprised of β˗1,4˗linked D˗mannuronic acid (M) and L˗guluronic acid (G). The polymer is naturally harvested from seaweed and is widely exploited in various biotechnological and biomedical applications, due to th... Read More about Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates.

FTIR study of zeolites: the nature, concentration and accessibility of the acid sites (2020)
Thesis
Antunes da Silva Freitas, C. M. (2020). FTIR study of zeolites: the nature, concentration and accessibility of the acid sites. (Thesis). Keele University

Zeolites represent one of the most important groups of industrial heterogeneous catalysts with large-scale applications in refining, petrochemistry and increasing potential in environmental catalysis and synthesis of fine chemicals. This broad range... Read More about FTIR study of zeolites: the nature, concentration and accessibility of the acid sites.

An investigation into the detection of fraud during poultry egg production: a metabonomic approach using liquid chromatography - mass spectrometry (2020)
Thesis
Johnson, A. E. (2020). An investigation into the detection of fraud during poultry egg production: a metabonomic approach using liquid chromatography - mass spectrometry. (Thesis). Keele University

Food fraud is becoming an increasingly difficult challenge, with the ongoing global expansion of food supply chains. Previously developed methods have been successful in the detection of some instances of food fraud, however they struggle to detect m... Read More about An investigation into the detection of fraud during poultry egg production: a metabonomic approach using liquid chromatography - mass spectrometry.