The development of anti-angiogenic heparan sulfate oligosaccharides (2014)
Journal Article
Jayson, G. C., Miller, G. J., Hansen, S. U., Barath, M., Gardiner, J. M., & Avizienyte, E. (2014). The development of anti-angiogenic heparan sulfate oligosaccharides. Biochemical Society Transactions, 42(6), 1596 -1600. https://doi.org/10.1042/BST20140229

Angiogenesis has emerged as a novel target for anti-cancer therapies through randomized clinical trials that tested the benefit of adding vascular endothelial growth factor (VEGF) inhibitors to conventional cytotoxic therapies. However, despite impro... Read More about The development of anti-angiogenic heparan sulfate oligosaccharides.

Optoelectronic properties ofTa3N5: A joint theoretical and experimental study (2014)
Journal Article
Morbec, J. M., Narkeviciute, I., Jaramillo, T. F., & Galli, G. (2014). Optoelectronic properties ofTa3N5: A joint theoretical and experimental study. Physical review B: Condensed matter and materials physics, https://doi.org/10.1103/PhysRevB.90.155204

A joint theoretical and experimental study of the optoelectronic properties of Ta3N5 was conducted by means of ab initio calculations and ellipsometry measurements. Previous experimental work on Ta3N5 has not been conclusive regarding the direct or i... Read More about Optoelectronic properties ofTa3N5: A joint theoretical and experimental study.

Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy (2014)
Journal Article
Miller, G. J., Hansen, S. U., Baráth, M., Johannessen, C., Blanch, E. W., Jayson, G. C., & Gardiner, J. M. (2014). Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy. Carbohydrate Research, 400, 44 -53. https://doi.org/10.1016/j.carres.2014.06.026

Synthesis of an array of differentially sulfated GlcN–IdoA disaccharides, accessible on good scale, directly from l-iduronate components is described. These are specifically directed to provide the sulfation variability at the key most common biologi... Read More about Synthesis of a heparin-related GlcN-IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy.

Biologically targeted probes for Zn2+: a diversity oriented modular “click-SNAr-click” approach (2014)
Journal Article
Watkinson. (2014). Biologically targeted probes for Zn2+: a diversity oriented modular “click-SNAr-click” approach. Chemical Science, 3528-3535. https://doi.org/10.1039/C4SC01249F

We describe a one-pot strategy for the high yielding, operationally simple synthesis of fluorescent probes for Zn2+ that bear biological targeting groups and exemplify the utility of our method through the preparation of a small library of sensors. I... Read More about Biologically targeted probes for Zn2+: a diversity oriented modular “click-SNAr-click” approach.

Directed assembly of optoelectronically active alkyl-p-conjugated molecules by adding n-alkanes or p-conjugated species (2014)
Journal Article
Hollamby, M., Karny, M., Bomans, P., Sommerdijk, N., Saeki, A., Seki, S., …Nakanishi, T. (2014). Directed assembly of optoelectronically active alkyl-p-conjugated molecules by adding n-alkanes or p-conjugated species. Nature Chemistry, 6, 690 - 696. https://doi.org/10.1038/nchem.1977

Supramolecular assembly can yield ordered structures by taking advantage of the cumulative effect of multiple non-covalent interactions between adjacent molecules. The thermodynamic origin of many self-assembled structures in water is the balance bet... Read More about Directed assembly of optoelectronically active alkyl-p-conjugated molecules by adding n-alkanes or p-conjugated species.

Mechanistic aspects of the tyrosinase oxidation of hydroquinone (2014)
Journal Article
(2014). Mechanistic aspects of the tyrosinase oxidation of hydroquinone. Bioorganic and Medicinal Chemistry Letters, 2463 - 2464. https://doi.org/10.1016/j.bmcl.2014.04.009

Contradictory reports on the behaviour of hydroquinone as a tyrosinase substrate are reconciled in terms of the ability of the initially formed ortho-quinone to tautomerise to the thermodynamically more stable para-quinone isomer. Oxidation of phenol... Read More about Mechanistic aspects of the tyrosinase oxidation of hydroquinone.

Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation (2014)
Journal Article
(2014). Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation. Bioorganic and Medicinal Chemistry, 2388 - 2395. https://doi.org/10.1016/j.bmc.2014.02.048

Tyrosinase is an enzyme widely distributed in the biosphere. It is one of a group of proteins with a strongly conserved bicopper active centre able to bind molecular oxygen. Tyrosinase manifests two catalytic properties; monooxygenase and oxidase act... Read More about Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation.

Application of inelastic neutron scattering to investigate the "dry" reforming of methane over an alumina-supported nickel catalyst operating under conditions where filamentous carbon formation is prevalent (2014)
Journal Article
Ormerod. (2014). Application of inelastic neutron scattering to investigate the "dry" reforming of methane over an alumina-supported nickel catalyst operating under conditions where filamentous carbon formation is prevalent. Abstracts of papers of the American Chemical Society, https://doi.org/10.1039/C3RA42435A

The use of CO2 in reforming methane to produce the industrial feedstock syngas is an economically and environmentally attractive reaction. An alumina-supported nickel catalyst active for this reaction additionally forms filamentous carbon. The cataly... Read More about Application of inelastic neutron scattering to investigate the "dry" reforming of methane over an alumina-supported nickel catalyst operating under conditions where filamentous carbon formation is prevalent.

Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice (2014)
Journal Article
Bake, T., Murphy, M., Morgan, D., & Mercer, J. (2014). Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice. Appetite, 77, 60 - 71. https://doi.org/10.1016/j.appet.2014.02.020

Male C57BL/6 mice fed ad libitum on control diet but allowed access to a palatable high fat diet (HFD) for 2?h a day during the mid-dark phase rapidly adapt their feeding behaviour and can consume nearly 80% of their daily caloric intake during this... Read More about Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice.

New insights into the catalytic activity of gold nanoparticles for CO oxidation in electrochemical media (2014)
Journal Article
Plana. (2014). New insights into the catalytic activity of gold nanoparticles for CO oxidation in electrochemical media. Journal of Catalysis, 182 -189. https://doi.org/10.1016/j.jcat.2013.11.020

This study reports the interaction between metal oxides and gold in acidic media and its effect on the electrochemical oxidation of carbon monoxide. We describe the oxidation of CO in acidic media on Au nanoparticles of 3 and 7 nm on different oxide... Read More about New insights into the catalytic activity of gold nanoparticles for CO oxidation in electrochemical media.

229Thorium-doped calcium fluoride for nuclear laser spectroscopy. (2014)
Journal Article
Jackson. (2014). 229Thorium-doped calcium fluoride for nuclear laser spectroscopy. Journal of Physics: Condensed Matter, 105402 -105402. https://doi.org/10.1088/0953-8984/26/10/105402

The (229)thorium isotope presents an extremely low-energy isomer state of the nucleus which is expected around 7.8 eV, in the vacuum ultraviolet (VUV) regime. This unique system may bridge between atomic and nuclear physics, enabling coherent manipul... Read More about 229Thorium-doped calcium fluoride for nuclear laser spectroscopy..