The role of steric effects and acidity in direct synthesis of iso-paraffins from syngas on cobalt zeolite catalysts (2015)
Journal Article
Zholobenko. (2015). The role of steric effects and acidity in direct synthesis of iso-paraffins from syngas on cobalt zeolite catalysts. ChemCatChem, 380-389. https://doi.org/10.1002/cctc.201500777

This study focuses on the effects of the localization of Co species, zeolite structure, and acidity on the performance of Co bifunctional catalysts promoted with Pt for the direct synthesis of iso-paraffins from syngas. ZSM-5, MOR, and BEA were chose... Read More about The role of steric effects and acidity in direct synthesis of iso-paraffins from syngas on cobalt zeolite catalysts.

Odorant receptor-based discovery of natural repellents of human lice (2015)
Journal Article
(2015). Odorant receptor-based discovery of natural repellents of human lice. Journal of Chemical Ecology, 103 - 109. https://doi.org/10.1016/j.ibmb.2015.10.009

The body louse, Pediculus humanus humanus, is an obligate blood-feeding ectoparasite and an important insect vector that mediates the transmission of diseases to humans. The analysis of the body louse genome revealed a drastic reduction of the chemos... Read More about Odorant receptor-based discovery of natural repellents of human lice.

Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains (2015)
Journal Article
Winter, A., Schmid, R., & Bayliss, R. (2015). Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains. PLoS Computational Biology, e1004548 - ?. https://doi.org/10.1371/journal.pcbi.1004548

Separases are large proteins that mediate sister chromatid disjunction in all eukaryotes. They belong to clan CD of cysteine peptidases and contain a well-conserved C-terminal catalytic protease domain similar to caspases and gingipains. However, unl... Read More about Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains.

Growth of epitaxial Pt1-xPbx alloys by surface limited redox replacement and study of their adsorption properties (2015)
Journal Article
(2015). Growth of epitaxial Pt1-xPbx alloys by surface limited redox replacement and study of their adsorption properties. Langmuir, 10904 -10912. https://doi.org/10.1021/acs.langmuir.5b02351

The surface limited redox replacement (SLRR) method has been used to design two-dimensional Pt-Pb nanoalloys with controlled thickness, composition, and structure. The electrochemical behavior of these alloys has been systematically studied as a func... Read More about Growth of epitaxial Pt1-xPbx alloys by surface limited redox replacement and study of their adsorption properties.

A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides (2015)
Journal Article
Miller, Miller, G. J., Broberg, K. R., Rudd, C., Helliwell, M. R., Jayson, G. C., & Gardiner, J. M. (2015). A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides. Organic and Biomolecular Chemistry, 13(46), 11208-11219. https://doi.org/10.1039/c5ob01706h

D-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important g... Read More about A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides.

Preparation and analysis of a new bioorganic metallic material (2015)
Journal Article
Yang. (2015). Preparation and analysis of a new bioorganic metallic material. RSC advances, 78030 -78037. https://doi.org/10.1039/c5ra16340d

Biofouling on metal surfaces is one of the main reasons for increased ship drag. Many methods have already been used to reduce or remove it with moderate success. In this study, a synthetic peptide has been utilized to react with 304 stainless steel... Read More about Preparation and analysis of a new bioorganic metallic material.

Surface activation of Pt nanoparticles synthesised by "hot injection" in the presence of oleylamine. (2015)
Journal Article
(2015). Surface activation of Pt nanoparticles synthesised by "hot injection" in the presence of oleylamine. Chemistry - A European Journal, 12694 -12701. https://doi.org/10.1002/chem.201501496

Oleylamine (OA) based "hot injection" colloidal synthesis offers a versatile approach to the synthesis of highly monodisperse metallic and multi-metallic alloyed nanostructures in the absence of potentially toxic and unstable phosphine compounds. For... Read More about Surface activation of Pt nanoparticles synthesised by "hot injection" in the presence of oleylamine..

Robust and ultrasensitive polymer membrane-based carbonate-selective electrodes (2015)
Journal Article
(2015). Robust and ultrasensitive polymer membrane-based carbonate-selective electrodes. Analytical Chemistry, 7515 - 7518. https://doi.org/10.1021/acs.analchem.5b01756

Quantitative analysis of the carbonate species within clinical and environmental samples is highly critical to the advancement of accurate environmental monitoring, disease screening, and personalized medicine. Herein we report the first example of c... Read More about Robust and ultrasensitive polymer membrane-based carbonate-selective electrodes.

Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. (2015)
Journal Article
Winter. (2015). Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chemical Science, 6147 - 6157. https://doi.org/10.1039/C5SC02155C

The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential for embryogenesis and for tissue/organ regeneration in post-natal life. HGF/SF-MET signall... Read More about Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding..

Optical properties of Pr and Eu-doped SrAl12O19: A theoretical study (2015)
Journal Article
Jackson. (2015). Optical properties of Pr and Eu-doped SrAl12O19: A theoretical study. Optical Materials, 105 - 109. https://doi.org/10.1016/j.optmat.2015.07.032

This paper describes a computational study of extrinsic defect and optical properties of SrAl12O19 induced by trivalent rare earth dopants. Solution energies for a range of possible doping mechanisms are calculated, and predictions made of doping sit... Read More about Optical properties of Pr and Eu-doped SrAl12O19: A theoretical study.

Making the longest sugars: a chemical synthesis of heparin-related [4](n) oligosaccharides from 16-mer to 40-mer (2015)
Journal Article
Hansen, S. U., Miller, G. J., Cliff, M. J., Jayson, G. C., & Gardiner, J. M. (2015). Making the longest sugars: a chemical synthesis of heparin-related [4](n) oligosaccharides from 16-mer to 40-mer. Chemical Science, 6(11), 6158 - 6164. https://doi.org/10.1039/C5SC02091C

The chemical synthesis of long oligosaccharides remains a major challenge. In particular, the synthesis of glycosaminoglycan (GAG) oligosaccharides belonging to the heparin and heparan sulfate (H/HS) family has been a high profile target, particularl... Read More about Making the longest sugars: a chemical synthesis of heparin-related [4](n) oligosaccharides from 16-mer to 40-mer.

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology (2015)
Journal Article
Jayson, G. C., Hansen, S. U., Miller, G. J., Cole, C. L., Rushton, G., Avizienytea, E., & Gardiner, J. M. (2015). Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology. Chemical Communications, 51(72), 13846 -13849. https://doi.org/10.1039/c5cc05222j

he multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modifica... Read More about Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology.

De novo Transcriptome Assemblies of Rana (Lithobates) catesbeiana and Xenopus laevis Tadpole Livers for Comparative Genomics without Reference Genomes (2015)
Journal Article
(2015). De novo Transcriptome Assemblies of Rana (Lithobates) catesbeiana and Xenopus laevis Tadpole Livers for Comparative Genomics without Reference Genomes. PloS one, e0130720 -?. https://doi.org/10.1371/journal.+pone.0130720

In this work we studied the liver transcriptomes of two frog species, the American bullfrog (Rana (Lithobates) catesbeiana) and the African clawed frog (Xenopus laevis). We used high throughput RNA sequencing (RNA-seq) data to assemble and annotate t... Read More about De novo Transcriptome Assemblies of Rana (Lithobates) catesbeiana and Xenopus laevis Tadpole Livers for Comparative Genomics without Reference Genomes.

Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids (2015)
Journal Article
Potter, G. T., Jayson, G. C., Miller, G. J., & Gardiner, J. M. (2015). Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids. Tetrahedron Letters, 56(37), 5153 - 5156. https://doi.org/10.1016/j.tetlet.2015.05.054

A series of aromatic and heteroaromatic primary amides were converted directly to carboxylic acids by heating with amyl nitrite in acetic acid. Most conversions proceeded to give reasonable to excellent yields on a range of substrates containing vari... Read More about Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids.

Release of toxic ammonia and volatile organic compounds by heated cannabis and their relation to tetrahydrocannabinol content (2015)
Journal Article
(2015). Release of toxic ammonia and volatile organic compounds by heated cannabis and their relation to tetrahydrocannabinol content. Analytical Methods, 4104 - 4110. https://doi.org/10.1039/C5AY00593K

Studies have been carried out of the compounds generated from heated “street” cannabis in the commercial device known as the “Volcano” using the selected ion flow tube mass spectrometry (SIFT-MS) analytical method. Such vaporising devices are preferr... Read More about Release of toxic ammonia and volatile organic compounds by heated cannabis and their relation to tetrahydrocannabinol content.

SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK (2015)
Journal Article
(2015). SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK. Analyst, 2573 - 2591. https://doi.org/10.1039/c4an02049a

Selected ion flow tube mass spectrometry, SIFT-MS, a relatively new gas/vapour phase analytical method, is derived from the much earlier selected ion flow tube, SIFT, used for the study of gas phase ion-molecule reactions. Both the SIFT and SIFT-MS t... Read More about SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK.

Modelling the concentration dependence of doping in optical materials (2015)
Journal Article
Jackson. (2015). Modelling the concentration dependence of doping in optical materials. IOP Conference Series: Materials Science and Engineering, https://doi.org/10.1088/1757-899X/80/1/012010

As well as understanding the location of dopants in optical materials, it is also important to understand how much dopant can be added to a given material. A method for calculating the maximum concentration of dopants has been developed, and applied... Read More about Modelling the concentration dependence of doping in optical materials.

Al adjuvants can be tracked in viable cells by lumogallion (2015)
Journal Article
(2015). Al adjuvants can be tracked in viable cells by lumogallion. Journal of Immunological Methods, 87-94. https://doi.org/10.1016/j.jim.2015.04.008

The mechanism behind the adjuvant effect of aluminum salts is poorly understood notwithstanding that aluminum salts have been used for decades in clinical vaccines. In an aqueous environment and at a nearly neutral pH, the aluminum salts form particu... Read More about Al adjuvants can be tracked in viable cells by lumogallion.

The Effect of Structure Directing Agents on the Ordering of Fluoride Ions in Pure Silica MFI Zeolites (2015)
Journal Article
Brace, S., Wormald, P., & Darton, R. (2015). The Effect of Structure Directing Agents on the Ordering of Fluoride Ions in Pure Silica MFI Zeolites. Physical Chemistry Chemical Physics, 17(18), 11950-11953. https://doi.org/10.1039/c5cp00834d

The effect of different sizes of structure directing agents on the ordering of the fluoride ions in pure silica MFI zeolites has been determined using magic angle spinning solid state NMR. By synthesizing fluoride containing pure silica MFI zeolites... Read More about The Effect of Structure Directing Agents on the Ordering of Fluoride Ions in Pure Silica MFI Zeolites.

Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications (2015)
Journal Article
Baráth, M., Hansen, S. U., Dalton, C. E., Jayson, G. C., Miller, G. J., & Gardiner, J. M. (2015). Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications. Molecules, 20(4), 6167 - 6180. https://doi.org/10.3390/molecules20046167

Heparin and heparan sulphate (H/HS) are important members of the glycosaminoglycan family of sugars that regulate a substantial number of biological processes. Such biological promiscuity is underpinned by hetereogeneity in their molecular structure.... Read More about Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications.