Indium(III) promoted oxidative P-P coupling of silylphosphines (2021)
Journal Article
Cartlidge, A. J., & Matthews, P. (2022). Indium(III) promoted oxidative P-P coupling of silylphosphines. Inorganica Chimica Acta, 120772 - 120772. https://doi.org/10.1016/j.ica.2021.120772

The reaction of indium(III) salts with Ph2PSiMe3 and PhP(SiMe3)2 gives rise to a one- and two-electron reductive P-P coupling respectively, with the formation of new P-P bonds resulting in the preparation of (Ph2P)2 and the cyclicoligophosphane compo... Read More about Indium(III) promoted oxidative P-P coupling of silylphosphines.

Monitoring of simulated clandestine graves of dismembered victims using UAVs, electrical tomography, and GPR over one year to aid investigations of human rights violations in Colombia, South America (2021)
Journal Article
Molina, C. M., Vasquez, A., Wisniewski, K., Heaton, V., Pringle, J., Avila, E. F., …Baena, A. (2022). Monitoring of simulated clandestine graves of dismembered victims using UAVs, electrical tomography, and GPR over one year to aid investigations of human rights violations in Colombia, South America. Journal of Forensic Sciences, 67(3), 1060-1071. https://doi.org/10.1111/1556-4029.14962

In most Latin American countries there are significant numbers of missing people and forced disappearances, over 90,000 in Colombia alone. Successful detection of shallow buried human remains by forensic search teams is difficult in varying terrain a... Read More about Monitoring of simulated clandestine graves of dismembered victims using UAVs, electrical tomography, and GPR over one year to aid investigations of human rights violations in Colombia, South America.

Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination. (2021)
Journal Article
Kehlenbeck, D., Traore, D. A., Josts, I., Sander, S., Moulin, M., Haertlein, M., …Tidow, H. (2022). Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination. FEBS Journal, 289(10), 2959-2970. https://doi.org/10.1111/febs.16327

The ATP-binding cassette transporter MsbA is a lipid flippase, translocating lipid A, glycolipids, and lipopolysaccharides from the inner to the outer leaflet of the inner membrane of Gram-negative bacteria. It has been used as a model system for tim... Read More about Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination..

Reaching new biocatalytic reactivity using continuous flow reactors (2021)
Journal Article
Cosgrove, S. C., & Mattey, A. P. (2022). Reaching new biocatalytic reactivity using continuous flow reactors. Chemistry - A European Journal, 28(13), https://doi.org/10.1002/chem.202103607

The use of flow reactors in biocatalysis has increased significantly in recent years. Chemists have begun to design flow systems that even allow new biocatalytic reactions to take place. This concept article will focus on the design of flow systems t... Read More about Reaching new biocatalytic reactivity using continuous flow reactors.

The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme. (2021)
Journal Article
(2021). The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme. Acta Crystallographica Section D: Structural Biology, 1579 - 1590. https://doi.org/10.1107/S2059798321010950

The biological function of a protein is intimately related to its structure and dynamics, which in turn are determined by the way in which it has been folded. In vitro refolding is commonly used for the recovery of recombinant proteins that are expre... Read More about The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme..

Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates (2021)
Journal Article
Reynisson, J., Wieczorek-Błauż, A., Kowalczyk, K., Błauż, A., Makal, A., Pawlędzio, S., …Plażuk, D. (2021). Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates. Dalton Transactions, 51(2), 491-508. https://doi.org/10.1039/d1dt03553c

The incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl analogs of monastrol - the first low molecular weight kinesin spin... Read More about Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates.

Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues (2021)
Journal Article
Guinan, M., Huang, N., Hawes, C. S., Lima, M. A., Smith, M., & Miller, G. J. (2021). Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues. Organic and Biomolecular Chemistry, 20(7), 1401-1406. https://doi.org/10.1039/d1ob02097h

Analogues of the canonical nucleosides required for nucleic acid synthesis have a longstanding presence and proven capability within antiviral and anticancer research. 4'-Thionucleosides, that incorporate bioisosteric replacement of furanose oxygen w... Read More about Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues.

Prospects for anti-Candida therapy through targeting the cell wall: A mini-review (2021)
Journal Article
Ahmadipour, S., Field, R. A., & Miller, G. (2021). Prospects for anti-Candida therapy through targeting the cell wall: A mini-review. The Cell Surface, 7, Article 100063. https://doi.org/10.1016/j.tcsw.2021.100063

The impact of fungal infections on humans is a serious public health issue that has received much less attention than bacterial infection and treatment, despite ever-increasing incidence exacerbated by an increased incidence of immunocompromised indi... Read More about Prospects for anti-Candida therapy through targeting the cell wall: A mini-review.

Laboratory exploration of mineral precipitates from Europa’s subsurface ocean (2021)
Journal Article
(2021). Laboratory exploration of mineral precipitates from Europa’s subsurface ocean. Journal of Applied Crystallography, 1455-1479. https://doi.org/10.1107/S1600576721008554

The precipitation of hydrated phases from a chondritic-like Na-Mg-Ca-SO4-Cl solution is studied using in situ synchrotron X-ray powder diffraction, under rapid (360
K hour-1, T = 250-80 K, t = 3 hours) and ultra-slow (0.3 K day-1, T= 273-245K, t = 2... Read More about Laboratory exploration of mineral precipitates from Europa’s subsurface ocean.

Developments in the Chemical Synthesis of Heparin and Heparan Sulfate (2021)
Journal Article
Pongener, I., O'Shea, C., Wootton, H., Watkinson, M., & Miller, G. J. (2021). Developments in the Chemical Synthesis of Heparin and Heparan Sulfate. Chemical Record, 21(11), 3238-3255. https://doi.org/10.1002/tcr.202100173

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of carbohydrates and underpin considerable repertoires of biological importance. As such, their efficiency of synthesis represents a key requirement, to further underst... Read More about Developments in the Chemical Synthesis of Heparin and Heparan Sulfate.

Radio continuum sources behind the Large Magellanic Cloud (2021)
Journal Article
Van Loon. (2021). Radio continuum sources behind the Large Magellanic Cloud. Monthly Notices of the Royal Astronomical Society, 2885 - 2904. https://doi.org/10.1093/mnras/stab2249

We present a comprehensive multifrequency catalogue of radio sources behind the Large Magellanic Cloud (LMC) between 0.2 and 20 GHz, gathered from a combination of new and legacy radio continuum surveys. This catalogue covers an area of ~144 deg2 at... Read More about Radio continuum sources behind the Large Magellanic Cloud.

Monitoring the early aggregatory behaviour and size of Aß1-42 in the absence & presence of metal ions using dynamic light scattering. (2021)
Journal Article
(2021). Monitoring the early aggregatory behaviour and size of Aß1-42 in the absence & presence of metal ions using dynamic light scattering. Journal of Trace Elements in Medicine and Biology, 1- 9. https://doi.org/10.1016/j.jtemb.2021.126766

BACKGROUND AND AIM: Aß1-42 is an amyloidogenic peptide found within senile plaques extracted from those who died with a diagnosis of Alzheimer's disease. The potent neurotoxicity of this peptide is related to its propensity to form aggregated conform... Read More about Monitoring the early aggregatory behaviour and size of Aß1-42 in the absence & presence of metal ions using dynamic light scattering..

A Potential Barrier Halting Spherically Symmetric Relativistic Gravitational Collapse (2021)
Book Chapter
Austin, J. C. (2021). A Potential Barrier Halting Spherically Symmetric Relativistic Gravitational Collapse. In Research Trends and Challenges in Physical Science (101-113). BP International. https://doi.org/10.9734/bpi/rtcps/v1/4203f

Discussion: Scholarly discussion on any scientific article or Book or Book chapter is very important for the advancement of science. We strongly suggest all readers and authors to participate in such activities. Comment posting facility is available... Read More about A Potential Barrier Halting Spherically Symmetric Relativistic Gravitational Collapse.

Ferroelectric semiconductor junctions based on graphene/In2Se3/graphene van der Waals heterostructures (2021)
Journal Article
Xie, S., Dey, A., Yan, W., Kudrynskyi, Z., Balakrishnan, N., Kovalyuk, Z., …Patane, A. (2021). Ferroelectric semiconductor junctions based on graphene/In2Se3/graphene van der Waals heterostructures. 2D Materials, 8(4), 1-9. https://doi.org/10.1088/2053-1583/ac1ada

The miniaturization of ferroelectric devices offers prospects for non-volatile memories, low-power electrical switches and emerging technologies beyond existing Si-based integrated circuits. An emerging class of ferroelectrics is based on van der Waa... Read More about Ferroelectric semiconductor junctions based on graphene/In2Se3/graphene van der Waals heterostructures.

Bacterial lipopolysaccharide recognition by surfactant protein D (2021)
Presentation / Conference
Shrive, & Greenhough. (2021, August). Bacterial lipopolysaccharide recognition by surfactant protein D. Presented at XXV IUCr Congress, Prague, Czech Republic

Human surfactant protein D is a collectin and member of the C-type lectin superfamily of proteins that forms an essential part of the mammalian innate immune system. The collectins have been recognised to not only bind to invading pathogens, allowing... Read More about Bacterial lipopolysaccharide recognition by surfactant protein D.

Lipopolysaccharide recognition by human surfactant protein D (2021)
Presentation / Conference
Neale, W., Madsen, J., Clark, H., Shrive, A., & Greenhough, T. (2021, August). Lipopolysaccharide recognition by human surfactant protein D. Presented at XXV IUCr Congress, Prague, Czech Republic

Optical spectroscopy study of Eu-doped ions in BaAl2O4 phosphors (2021)
Journal Article
Rezende, M. D. S., Valerio, M., Araujo, R., Jackson, R., dos Santos Mattos, E., & dos Santos Junior, B. (2021). Optical spectroscopy study of Eu-doped ions in BaAl2O4 phosphors. Journal of Luminescence, 1-5. https://doi.org/10.1016/j.jlumin.2021.118011

Computational and experimental methodology is employed to study optical properties in Eu-doped BaAl2O4 phosphors. The symmetry and detailed geometry of the Eu-dopant site, predicted by atomistic simulation, are used to calculate the crystal field par... Read More about Optical spectroscopy study of Eu-doped ions in BaAl2O4 phosphors.

Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions (2021)
Journal Article
Barnes, N. G., Ahmed Mal Ullah, A. A., Ragazzon, P. A., Charafi, N., & Hadfield, J. A. (2021). Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions. ChemistrySelect, 6(28), 7082 - 7086. https://doi.org/10.1002/slct.202101960

Combretastatin A-4 (CA4) is a potent anti-mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions.

Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses. (2021)
Journal Article
Kyriacou. (2021). Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses. ACS Omega, 19901 - 19910. https://doi.org/10.1021/acsomega.1c02796

The characteristics of a material's surface are extremely important when considering their interactions with biological species. Despite surface chemistry playing a critical role in mediating the responses of cells, there remains no single rule which... Read More about Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses..

Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition (2021)
Journal Article
Kumawat, L. K., Wynne, C., Cappello, E., Fisher, P., Brennan, L. E., Strofaldi, A., …Elmes, R. B. P. (2021). Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition. ChemPlusChem, 86(8), 1058-1068. https://doi.org/10.1002/cplu.202100275

The synthesis and characterisation of two novel self‐assembled amphiphiles (SSAs) SQS‐1 and SQS‐2 are reported. Both compounds, based on the squaramide motif, were fully soluble in a range of solvents and were shown to undergo self‐assembly through a... Read More about Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition.