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Investigating the interaction between dengue viral envelope proteins and host receptor molecules (2022)
Thesis
Hyatt, J. G. (2022). Investigating the interaction between dengue viral envelope proteins and host receptor molecules. (Thesis). Keele University

Infection of dengue remains to this date a major socio-economic and public health challenge for large parts of the world, especially low- and middle- income countries in the tropics and sub-tropics. Despite the prevalence of the associated neglected... Read More about Investigating the interaction between dengue viral envelope proteins and host receptor molecules.

Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds (2022)
Journal Article
Mogas Barcons, A., Chowdhury, F., Chari, D. M., & Adams, C. (2022). Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds. Materials, 16(1), Article 124. https://doi.org/10.3390/ma16010124

Spinal cord injury is debilitating with functional loss often permanent due to a lack of neuro-regenerative or neuro-therapeutic strategies. A promising approach to enhance biological function is through implantation of tissue engineered constructs,... Read More about Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds.

Synthesis of a B-Antigen Hexasaccharide, a B-Lewis b Heptasaccharide and Glycoconjugates Thereof to Investigate Binding Properties of Helicobacter pylori (2022)
Journal Article
Reihill, M., Fournière, V., Cheallaigh, A. N., Edlund, J. O., Miller, G. J., Borén, T., …Oscarson, S. (2023). Synthesis of a B-Antigen Hexasaccharide, a B-Lewis b Heptasaccharide and Glycoconjugates Thereof to Investigate Binding Properties of Helicobacter pylori. Chemistry - A European Journal, 29(16), Article e202203672. https://doi.org/10.1002/chem.202203672

AbstractInfecting the stomach of almost 50 % of people, Helicobacter pylori is a causative agent of gastritis, peptic ulcers and stomach cancers. Interactions between bacterial membrane‐bound lectin, Blood group Antigen Binding Adhesin (BabA), and hu... Read More about Synthesis of a B-Antigen Hexasaccharide, a B-Lewis b Heptasaccharide and Glycoconjugates Thereof to Investigate Binding Properties of Helicobacter pylori.

Reeling them in: Ph2PSiMe3 in the sequential formation of InP magic-sized clusters (2022)
Journal Article
Gazis, T. A., & Matthews, P. D. (2022). Reeling them in: Ph2PSiMe3 in the sequential formation of InP magic-sized clusters. Chemical Communications, 58(99), 13799 - 13802. https://doi.org/10.1039/D2CC06204F

Indium phosphide magic-sized clusters (MSCs) have been identified as a key step in the growth of InP quantum dots (QDs). However, the need for elevated temperatures to form QDs from MSCs has limited our understanding of this transformation. Herein, w... Read More about Reeling them in: Ph2PSiMe3 in the sequential formation of InP magic-sized clusters.

Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis (2022)
Journal Article
Cosgrove, Miller, & Dolan. (2022). Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis. JACS Au, 47-61. https://doi.org/10.1021/jacsau.2c00529

While the field of biocatalysis has bloomed over the past 20–30 years, advances in the understanding and improvement of carbohydrate-active enzymes, in particular, the sugar nucleotides involved in glycan building block biosynthesis, have progressed... Read More about Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis.

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. (2022)
Journal Article
Rotherham, M., Moradi, Y., Nahar, T., Mosses, D., Telling, N., & El Haj, A. (2022). Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. Frontiers in Medical Technology, 4, Article 981421. https://doi.org/10.3389/fmedt.2022.981421

TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter... Read More about Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells..

Effect of trivalent rare earth doping in cadmium silicates hosts: a theoretical study (2022)
Journal Article
Santos, A., Bispo, G., Freire, E., Macedo, Z., Jackson, R., & Valerio, M. (2022). Effect of trivalent rare earth doping in cadmium silicates hosts: a theoretical study. Physica Scripta, https://doi.org/10.1088/1402-4896/aca228

The objective of the present work is to investigate the possibilities for extrinsic defects in the three cadmium silicate matrices, CdSiO3, Cd2SiO4 and Cd3SiO5 and understand the final geometry of the most energetically favourable defects, which are... Read More about Effect of trivalent rare earth doping in cadmium silicates hosts: a theoretical study.

Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats (2022)
Journal Article
(2022). Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats. Metabolites, 1188 - 1188. https://doi.org/10.3390/metabo12121188

<jats:p>Aluminum (Al) is a non-essential metal omnipresent in human life and is considered an environmental toxicant. Al increases reactive oxygen production and triggers immune responses, contributing to chronic systemic inflammation development. He... Read More about Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats.

Fused aza-heterocyclic ligands: expanding the MOF chemist's toolbox (2022)
Journal Article
Wood, O. G., & Hawes, C. S. (2022). Fused aza-heterocyclic ligands: expanding the MOF chemist's toolbox. CrystEngComm, 24(47), 8197-8207. https://doi.org/10.1039/d2ce01475k

Azolate-containing ligands have played an important role in the development of water-stable metal-organic frameworks (MOFs) and related materials due to their particularly strong bonding with earth-abundant first row transition metal ions. Fused ring... Read More about Fused aza-heterocyclic ligands: expanding the MOF chemist's toolbox.

Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues (2022)
Journal Article
Benckendorff, C., Slyusarchuk, V. D., Huang, N., Lima, M. A., Smith, M., & Miller, G. J. (2022). Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues. Organic and Biomolecular Chemistry, 20(47), 9469 - 9489. https://doi.org/10.1039/D2OB01761J

Analogues of the canonical nucleosides have a longstanding presence and proven capability within medicinal chemistry and drug discovery research. The synthesis reported herein successfully replaces furanose oxygen with CF2 and CHF in pyrimidine nucle... Read More about Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues.

A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching. (2022)
Journal Article
Collings, A., & Craik, K. (2022). A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching. Science and Justice, 814 - 821. https://doi.org/10.1016/j.scijus.2022.04.006

Forensic anthropology has traditionally relied on two-dimensional (2D) images, such as photographs and sketches, to perform analyses, and disseminate findings. However, as 3D imaging technology advances, it has become more widely implemented into for... Read More about A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching..

Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands (2022)
Journal Article
Slyusarchuk, V. D., O’Brien, B. J., & Hawes, C. S. (in press). Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands. Journal of Coordination Chemistry, 75(15-16), 2039-2061. https://doi.org/10.1080/00958972.2022.2130059

Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands

The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. (2022)
Journal Article
Fettiplace, R., Furness, D. N., & Beurg, M. (2022). The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. Proceedings of the National Academy of Sciences of the United States of America, 119(41), Article e2210849119. https://doi.org/10.1073/pnas.2210849119

Transmembrane channel-like protein 1 (TMC1) is thought to form the ion-conducting pore of the mechanoelectrical transducer (MET) channel in auditory hair cells. Using single-channel analysis and ionic permeability measurements, we characterized six m... Read More about The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells..

Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase. (2022)
Journal Article
Ahmadipour, S., Wahart, A., Dolan, J., Beswick, L., Hawes, C., Field, R., & Miller, G. (2022). Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase. Beilstein Journal of Organic Chemistry, 18, 1379 - 1384. https://doi.org/10.3762/bjoc.18.142

Sufferers of cystic fibrosis are at significant risk of contracting chronic bacterial lung infections. The dominant pathogen in these cases is mucoid Pseudomonas aeruginosa. Such infections are characterised by overproduction of the exopolysaccharide... Read More about Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase..

The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022 (2022)
Journal Article
Beard, P. (2022). The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022. Eurosurveillance, https://doi.org/10.2807/1560-7917.es.2022.27.39.2200758

<jats:p>We report results of surveillance between June and mid-September 2022 of pet animals living in households of confirmed human monkeypox (MPX) cases. Since surveillance commenced, 154 animals from 40 households with a confirmed human MPX case w... Read More about The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022.

Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti (2022)
Journal Article
Logan, R., Quek, S., Muthoni, J., von Eicken, A., Brettell, L., Anderson, E., …Patterson, E. (2022). Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti. Applied and Environmental Microbiology, https://doi.org/10.1128/aem.01062-22

Cell fusing agent virus (CFAV) is an insect-specific flavivirus (ISF) found in Aedes aegypti mosquitoes. ISFs have demonstrated the ability to modulate the infection or transmission of arboviruses such as dengue, West Nile, and Zika viruses. It is th... Read More about Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti.

Does iron chelation by eumelanin contribute to the ethnic link with maternal mortality? (2022)
Journal Article
(2022). Does iron chelation by eumelanin contribute to the ethnic link with maternal mortality?. European Journal of Obstetrics and Gynecology and Reproductive Biology, 107 - 108. https://doi.org/10.1016/j.ejogrb.2022.09.012

Significant disparities in maternal mortality between white and black mothers have been noted for over 80 years and remain an extremely serious problem. Black women are still four times more likely than white women to die in pregnancy or childbirth i... Read More about Does iron chelation by eumelanin contribute to the ethnic link with maternal mortality?.

Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions (2022)
Journal Article
P. Dolan, J., Machin, D. C., Dedola, S., Field2, R. A., Webb, M. E., & Bruce Turnbull, W. (2022). Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions. Frontiers in Chemistry, https://doi.org/10.3389/fchem.2022.958272

<jats:p>The chemoenzymatic synthesis of a series of dual N- and C-terminal–functionalized cholera toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different levels of Tn antigen glycosylation [MUC1(Tn)] were prepared <jats... Read More about Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions.

A comprehensive study on the processing of Co:ZnO nanostructured ceramics: Defect chemistry engineering and grain growth kinetics (2022)
Journal Article
da Silva, R., Morbec, J., Rahman, G., & de Carvalho, H. (2022). A comprehensive study on the processing of Co:ZnO nanostructured ceramics: Defect chemistry engineering and grain growth kinetics. Journal of Materials Science and Technology, 221-232. https://doi.org/10.1016/j.jmst.2022.07.038

In this report, we present a systematic study on the preparation of Co:ZnO ceramics via a standard solid-state route from different Co precursors (Co3O4, CoO, and metallic Co) and atmospheres (O2 and Ar). Particular emphasis is given to defect chemis... Read More about A comprehensive study on the processing of Co:ZnO nanostructured ceramics: Defect chemistry engineering and grain growth kinetics.