The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions (2020)
Journal Article
Frank, F., Kavousi, N., Bountali, A., B. Dammer, E., Mourtada-Maarabouni, M., & A. Ortlund, E. (2020). The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions. Cell Reports, https://doi.org/10.1016/j.celrep.2020.107933

There is increasing evidence that the architecture of long non-coding RNAs (lncRNAs) just like that of proteins-is hierarchically organized into independently folding sub-modules with distinct functions. Studies characterizing the cellular activities... Read More about The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions.

Self-assembled poly-catenanes from supramolecular toroidal building blocks (2020)
Journal Article
Datta, S., Kato, Y., Higashiharaguchi, S., Aratsu, K., Isobe, A., Saito, T., …Yagai, S. (2020). Self-assembled poly-catenanes from supramolecular toroidal building blocks. Nature, 583, 400 - 405. https://doi.org/10.1038/s41586-020-2445-z

Mechanical interlocking of molecules (catenation) is a nontrivial challenge in modern synthetic chemistry and materials science1,2. One strategy to achieve catenation is the design of pre-annular molecules that are capable of both efficient cyclizati... Read More about Self-assembled poly-catenanes from supramolecular toroidal building blocks.

Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities. (2020)
Journal Article
Ní Cheallaigh, A., Guimond, S., Oscarson, S., & Miller, G. (2020). Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities. Carbohydrate Research, 495, Article 108085. https://doi.org/10.1016/j.carres.2020.108085

'No abstract'

Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa (2020)
Thesis
Beswick, L. E. M. (2020). Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa. (Thesis). Keele University

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterium, responsible for causing life threatening infections amongst fibrosis (CF) patients. Mucoid phenotypes of P. aeruginosa are characterised by overproduction of alginate, an extra-cel... Read More about Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa.

Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates (2020)
Thesis
Dimitriou, E. (2020). Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates. (Thesis). Keele University

Alginate is an anionic polysaccharide comprised of β˗1,4˗linked D˗mannuronic acid (M) and L˗guluronic acid (G). The polymer is naturally harvested from seaweed and is widely exploited in various biotechnological and biomedical applications, due to th... Read More about Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates.

Synthetic biology open language (SBOL) version 3.0.0. (2020)
Journal Article
Bartley, B., Beal, J., McLaughlin, J., Vaidyanathan, P., Baig, H., Fontanarrosa, P., …Myers, C. (2020). Synthetic biology open language (SBOL) version 3.0.0. Journal of Integrative Bioinformatics, https://doi.org/10.1515/jib-2020-0017

Synthetic biology builds upon genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. When designing a synthetic system, synthetic biologists need to exchange information about mu... Read More about Synthetic biology open language (SBOL) version 3.0.0..

A planet within the debris disk around the pre-main-sequence star AU Microscopii. (2020)
Journal Article
Hellier. (2020). A planet within the debris disk around the pre-main-sequence star AU Microscopii. Nature, 497 - 500. https://doi.org/10.1038/s41586-020-2400-z

AU Microscopii (AU Mic) is the second closest pre-main-sequence star, at a distance of 9.79 parsecs and with an age of 22 million years1. AU Mic possesses a relatively rare2 and spatially resolved3 edge-on debris disk extending from about 35 to 210 a... Read More about A planet within the debris disk around the pre-main-sequence star AU Microscopii..

Bacterial phylogeny predicts volatile organic compound composition and olfactory response of an aphid parasitoid (2020)
Journal Article
(2020). Bacterial phylogeny predicts volatile organic compound composition and olfactory response of an aphid parasitoid. Oikos, https://doi.org/10.1111/oik.07301

There is increasing evidence that microorganisms emit a wide range of volatile compounds (mVOCs, microbial volatile organic compounds) that act as insect semiochemicals, and therefore play an important role in insect behaviour. Although it is general... Read More about Bacterial phylogeny predicts volatile organic compound composition and olfactory response of an aphid parasitoid.

Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation (2020)
Journal Article
Harper. (2020). Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation. Cell Calcium, 90, Article 102248. https://doi.org/10.1016/j.ceca.2020.102248

Human platelets use a rise in cytosolic Ca2+ concentration to activate all stages of thrombus formation, however, how they are able to decode cytosolic Ca2+ signals to trigger each of these independently is unknown. Other cells create local Ca2+ sign... Read More about Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation.

The Gaia-ESO Survey: Membership probabilities for stars in 32 open clusters from 3D kinematics (2020)
Journal Article
Jeffries, & Wright. (2020). The Gaia-ESO Survey: Membership probabilities for stars in 32 open clusters from 3D kinematics. Monthly Notices of the Royal Astronomical Society, 4701-4716. https://doi.org/10.1093/mnras/staa1749

The Gaia-ESO Survey (GES) observed many open clusters as part of its programme to spectroscopically characterise the various Milky Way populations. GES spectroscopy and Gaia astrometry from its second data release are used here to assign membership p... Read More about The Gaia-ESO Survey: Membership probabilities for stars in 32 open clusters from 3D kinematics.

Anti- and pro-oxidative mechanisms comparing the macular carotenoids zeaxanthin and lutein with other dietary carotenoids - a singlet oxygen, free-radical in vitro and ex vivo study. (2020)
Journal Article
(2020). Anti- and pro-oxidative mechanisms comparing the macular carotenoids zeaxanthin and lutein with other dietary carotenoids - a singlet oxygen, free-radical in vitro and ex vivo study. Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences, 1001-1008. https://doi.org/10.1039/d0pp00120a

The interactions of dietary carotenoids, and particularly the xanthophylls in the macula, with singlet oxygen and three different oxy-radicals, (hydroxyl radical, nitrogen dioxide and the superoxide radical anion) are compared using pulsed laser and... Read More about Anti- and pro-oxidative mechanisms comparing the macular carotenoids zeaxanthin and lutein with other dietary carotenoids - a singlet oxygen, free-radical in vitro and ex vivo study..

Reconstruction and physical fit analysis of fragmented skeletal remains using 3D imaging and printing (2020)
Journal Article
Collings, A. (2020). Reconstruction and physical fit analysis of fragmented skeletal remains using 3D imaging and printing. Forensic Science International: Reports, 100114 - 100114. https://doi.org/10.1016/j.fsir.2020.100114

Physical fit analysis (PFA) entails physically fitting fragmented evidence together to determine shared origin. PFA can be challenging to conduct with bone fragments particularly when fragile, sharp, or embedded in other materials. Three-dimensional... Read More about Reconstruction and physical fit analysis of fragmented skeletal remains using 3D imaging and printing.

Barium isotopic composition of the mantle: Constraints from carbonatites (2020)
Journal Article
Li, W., Yu, H., Xu, J., Halama, R., Bell, K., Nan, X., & Huang, F. (2020). Barium isotopic composition of the mantle: Constraints from carbonatites. Geochimica et Cosmochimica Acta, 235-243. https://doi.org/10.1016/j.gca.2019.06.041

To investigate the behaviour of Ba isotopes during carbonatite petrogenesis and to explore the possibility of using carbonatites to constrain the Ba isotopic composition of the mantle, we report high-precision Ba isotopic analyses of: (1) carbonatite... Read More about Barium isotopic composition of the mantle: Constraints from carbonatites.

FTIR study of zeolites: the nature, concentration and accessibility of the acid sites (2020)
Thesis
Antunes da Silva Freitas, C. M. (2020). FTIR study of zeolites: the nature, concentration and accessibility of the acid sites. (Thesis). Keele University

Zeolites represent one of the most important groups of industrial heterogeneous catalysts with large-scale applications in refining, petrochemistry and increasing potential in environmental catalysis and synthesis of fine chemicals. This broad range... Read More about FTIR study of zeolites: the nature, concentration and accessibility of the acid sites.

Balancing connectivity with function in silver(i) networks of pyridyltriazole (tzpa) ligands results in the formation of a metallogel (2020)
Journal Article
Hegarty, I. N., Dalton, H. L., Lynes, A. D., Haffner, B., Möbius, M. E., Hawes, C. S., & Gunnlaugsson, T. (2020). Balancing connectivity with function in silver(i) networks of pyridyltriazole (tzpa) ligands results in the formation of a metallogel. Dalton Transactions, 7364-7372. https://doi.org/10.1039/D0DT01421D

A new flexible and divergent 1,2,3-triazol-4-yl-picolinamide (tzpa) ligand 2 and the half-equivalent model ligand 1, both functionalised with pendant 3-pyridyl groups, are reported and their coordination behaviour with silver(i) ions is explored, bot... Read More about Balancing connectivity with function in silver(i) networks of pyridyltriazole (tzpa) ligands results in the formation of a metallogel.

Stoichiometric methane conversion to ethane using photochemical looping at ambient temperature (2020)
Journal Article
Yu, X., Hu, D., Wu, D., Ordomsky, V., Khodakov, A., Zholobenko, V., & Moldovan, S. (2020). Stoichiometric methane conversion to ethane using photochemical looping at ambient temperature. https://doi.org/10.1038/s41560-020-0616-7

Methane activation and utilization are among the major challenges of modern science. Methane is potentially an important feedstock for manufacturing value-added fuels and chemicals. However, most known processes require excessive operating temperatur... Read More about Stoichiometric methane conversion to ethane using photochemical looping at ambient temperature.

A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme. (2020)
Journal Article
Yuan, D., Cai, N., Xu, J., Miao, D., Zhang, S., Woodfine, S. E., …Watkinson, M. (2020). A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme. ChemPlusChem, 85(6), 1210 - 1219. https://doi.org/10.1002/cplu.202000337

The development of a team-based approach to research-led transnational practical chemistry teaching is described in which a team of five Chinese students on an articulated transnational degree programme, supported by a team of academic and technical... Read More about A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme..

Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer's disease, multiple sclerosis and autism (2020)
Journal Article
Exley, C., & Clarkson, E. (2020). Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer's disease, multiple sclerosis and autism. Scientific reports, 10(1), Article ARTN 7770. https://doi.org/10.1038/s41598-020-64734-6

A burgeoning number of studies are demonstrating aluminium in human brain tissue. While research has both quantified and imaged aluminium in human brain tissue in neurodegenerative and neurodevelopmental disease there are few similar data for brain t... Read More about Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer's disease, multiple sclerosis and autism.

Insights into the magma plumbing system of La Fossa di Vulcano (Aeolian Islands, Italy) using oxygen isotopes and clinopyroxene crystal structure (2020)
Journal Article
Wiltshire, R., Halama, R., Boyce, A., Petrone, C., Nazzareni, S., Gertisser, R., …Lucchi, F. (2020). Insights into the magma plumbing system of La Fossa di Vulcano (Aeolian Islands, Italy) using oxygen isotopes and clinopyroxene crystal structure. https://doi.org/10.5194/egusphere-egu2020-13433

<jats:p> &amp;lt;p&amp;gt;The presently active La Fossa cone, Vulcano, widely considered the most hazardous volcano in the Aeolian Islands, is characterised by alternating periods of Vulcanian to subplinian explosive events and lava flow effusion. It... Read More about Insights into the magma plumbing system of La Fossa di Vulcano (Aeolian Islands, Italy) using oxygen isotopes and clinopyroxene crystal structure.

Cyclic Aliphatic Hydrocarbons as Linkers in Metal-Organic Frameworks: New Frontiers for Ligand Design. (2020)
Journal Article
Hawes, C. S. (2020). Cyclic Aliphatic Hydrocarbons as Linkers in Metal-Organic Frameworks: New Frontiers for Ligand Design. ChemPlusChem, 845 - 854. https://doi.org/10.1002/cplu.202000206

In this Minireview we outline the development of cyclic aliphatic moieties as ligands in metal-organic frameworks (MOFs), with a focus on the relationship between ligand design and synthesis and the properties of the subsequent materials. Aliphatic l... Read More about Cyclic Aliphatic Hydrocarbons as Linkers in Metal-Organic Frameworks: New Frontiers for Ligand Design..