The proteome of the infectious bronchitis virus Beau-R virion. (2015)
Journal Article
(2015). The proteome of the infectious bronchitis virus Beau-R virion. Journal of General Virology, 3499 - 3506. https://doi.org/10.1099/jgv.0.000304

Infectious bronchitis is a highly contagious respiratory disease of poultry caused by the coronavirus infectious bronchitis virus (IBV). It was thought that coronavirus virions were composed of three major viral structural proteins until investigatio... Read More about The proteome of the infectious bronchitis virus Beau-R virion..

P2X 7 receptor activity regulation: the role of CD44 proteoglycan GAG chains (2015)
Journal Article
Moura, G., Lucena, S., Andrade De Lima, M., Nascimento, F., Gesteira, T., Nader, H., …Tersariol, I. (2015). P2X 7 receptor activity regulation: the role of CD44 proteoglycan GAG chains. Cell death and disease, https://doi.org/10.1038/cddis.2015.340

P2X7 receptors have received special attention in the literature for their involvement in several diseases characterized by inflammatory processes such as cancer, arthritis, neurodegenerative pathologies and chronic pains.

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region (2015)
Journal Article
Russo. (2015). Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region. PloS one, e0142509 - e0142509. https://doi.org/10.1371/journal.pone.0142509

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essent... Read More about Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes (2015)
Journal Article
Masood. (2015). The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes. BMC Infectious Diseases, https://doi.org/10.1186/s12879-015-1210-7

Background
The most common cause of Gram-negative bacterial neonatal meningitis is E. coli K1. It has a mortality rate of 10–15 %, and neurological sequelae in 30–50 % of cases. Infections can be attributable to nosocomial sources, however the pre-c... Read More about The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes.

Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans (2015)
Journal Article
Moura, G., Lucena, S., Andrade De Lima, M., Nascimento, F., Gesteira, T., Nader, H., …Tersariol, I. (2015). Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans. Cell Death Discovery, 1, 15005--15005. https://doi.org/10.1038/cddiscovery.2015.5

Here, we present evidence for the positive allosteric modulation of the P2X7 receptor through glycosaminoglycans (GAGs) in CHO (cell line derived from the ovary of the Chinese hamster) cells. The marked potentiation of P2X7 activity through GAGs in t... Read More about Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans.

Non-cardiovascular comorbidity, severity and prognosis in non-selected heart failure populations: A systematic review and meta-analysis (2015)
Journal Article
(2015). Non-cardiovascular comorbidity, severity and prognosis in non-selected heart failure populations: A systematic review and meta-analysis. https://doi.org/10.1016/j.ijcard.2015.05.180

BACKGROUND: Non-cardiovascular comorbidities are recognised as independent prognostic factors in selected heart failure (HF) populations, but the evidence on non-selected HF and how comorbid disease severity and change impacts on outcomes has not bee... Read More about Non-cardiovascular comorbidity, severity and prognosis in non-selected heart failure populations: A systematic review and meta-analysis.

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke (2015)
Journal Article
Wong, R., Pradillo, J. M., Denes, A., Dhungana, H., Malm, T., Koistinaho, J., …Maysami, S. (2015). A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. Journal of Cerebral Blood Flow and Metabolism, 36(3), 596-605. https://doi.org/10.1177/0271678X15606714

Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in... Read More about A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.

Non-random patterns in viral diversity (2015)
Journal Article
Anthony, S., Islam, A., Johnson, C., Navarrete-Macias, I., Liang, E., Jain, K., …Lipkin, W. (2015). Non-random patterns in viral diversity. Nature communications, https://doi.org/10.1038/ncomms9147

It is currently unclear whether changes in viral communities will ever be predictable. Here we investigate whether viral communities in wildlife are inherently structured (inferring predictability) by looking at whether communities are assembled thro... Read More about Non-random patterns in viral diversity.

Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides (2015)
Journal Article
Hart, S. R., Kenny, L. C., Myers, J. E., & Baker, P. N. (2015). Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides. International Journal of Mass Spectrometry, 391, 41-46. https://doi.org/10.1016/j.ijms.2015.08.025

Urine as a biofluid is commonly used in clinical diagnostics, including those performed during pregnancy. Urine is a rich source of polypeptides and polypeptidic protein degradation products, which have been filtered from blood plasma, thus urine has... Read More about Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides.

Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer. (2015)
Journal Article
Kitchen, M. O., Bryan, R. T., Haworth, K. E., Emes, R. D., Luscombe, C., Gommersall, L., …Farrell, W. E. (2015). Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer. PloS one, e0137003 - ?. https://doi.org/10.1371/journal.pone.0137003

INTRODUCTION: Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladder... Read More about Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer..

An optimized proportional-derivative controller for the human upper extremity with gravity (2015)
Journal Article
(2015). An optimized proportional-derivative controller for the human upper extremity with gravity. Journal of Biomechanics, 3692-3700. https://doi.org/10.1016/j.jbiomech.2015.08.016

When Functional Electrical Stimulation (FES) is used to restore movement in subjects with spinal cord injury (SCI), muscle stimulation patterns should be selected to generate accurate and efficient movements. Ideally, the controller for such a neurop... Read More about An optimized proportional-derivative controller for the human upper extremity with gravity.

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. (2015)
Journal Article
Maysami, S., Haley, M., Gorenkova, N., Krishnan, S., McColl, B., & Lawrence, C. (2015). Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. Journal of Neuroinflammation, 140 - ?. https://doi.org/10.1186/s12974-015-0359-8

BACKGROUND: Obesity increases the risk for ischaemic stroke and is associated with worse outcome clinically and experimentally. Most experimental studies have used genetic models of obesity. Here, a more clinically relevant model, diet-induced obesit... Read More about Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke..

Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner. (2015)
Journal Article
Dale, T. P., de Castro, A., Kuiper, N. J., Parkinson, E. K., & Forsyth, N. R. (2015). Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner. PloS one, 10(7), Article e0133745. https://doi.org/10.1371/journal.pone.0133745

BACKGROUND: Limited options for the treatment of cartilage damage have driven the development of tissue engineered or cell therapy alternatives reliant on ex vivo cell expansion. The study of chondrogenesis in primary cells is difficult due to progre... Read More about Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner..

Feasibility of using combined EMG and kinematic signals for prosthesis control: a simulation study using a virtual reality environment (2015)
Journal Article
Kyriacou. (2015). Feasibility of using combined EMG and kinematic signals for prosthesis control: a simulation study using a virtual reality environment. Journal of Electromyography and Kinesiology, 21-27. https://doi.org/10.1016/j.jelekin.2015.06.010

Transhumeral amputation has a significant effect on a person’s independence and quality of life. Myoelectric prostheses have the potential to restore upper limb function, however their use is currently limited due to lack of intuitive and natural con... Read More about Feasibility of using combined EMG and kinematic signals for prosthesis control: a simulation study using a virtual reality environment.

Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry (2015)
Journal Article
(2015). Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry. Rapid communications in mass spectrometry RCM, 1069 - 1079. https://doi.org/10.1002/rcm.7198

RATIONALE: It has been proposed that malondialdehyde (MDA) reflects free oxygen-radical lipid peroxidation and can be useful as a biomarker to track this process. For the analysis of MDA molecules in humid air by selected ion flow tube mass spectrome... Read More about Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry.

Cervical cancer is not just a young woman's disease (2015)
Journal Article
Redman, C., Sherman, S., Castanon, A., & Moss, E. (2015). Cervical cancer is not just a young woman's disease. BMJ, h2729 -?. https://doi.org/10.1136/bmj.h2729

Cervical screening programmes in many countries stop at around the age of 65 and much of the focus is often on younger women. For example, recent media campaigns in England and Wales have centred on lowering the age at first screening. Comparatively... Read More about Cervical cancer is not just a young woman's disease.

Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability (2015)
Journal Article
Walter, M., Kohli, N., Major, T., Fuller, H., Wright, K., Kuiper, J., & Johnson, W. (2015). Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. Journal of Stem Cells and Regenerative Medicine, 11(1), 18-24. https://doi.org/10.46582/jsrm.1101004

Mesenchymal stem cells (MSCs) stimulate angiogenesis within a wound environment and this effect is mediated through paracrine interactions with the endothelial cells present. Here we report that human MSC-conditioned medium (n=3 donors) significantly... Read More about Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability.

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion (2015)
Journal Article
Roberts, S., Evans, H., Wright, K., van Niekerk, L., Caterson, B., Richardson, J., …Kuiper, J. (2015). ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis and Cartilage, 23(9), 1622-1626. https://doi.org/10.1016/j.joca.2015.05.006

Objective
To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease.

Design
We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with di... Read More about ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion.

X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein (2015)
Journal Article
(2015). X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein. PloS one, e0123338 - e0123338. https://doi.org/10.1371/journal.pone.0123338

Phanta is a reversibly photoswitching chromoprotein (FF, 0.003), useful for pcFRET, that was isolated from a mutagenesis screen of the bright green fluorescent eCGP123 (FF, 0.8). We have investigated the contribution of substitutions at positions His... Read More about X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein.

Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features. (2015)
Journal Article
(2015). Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features. PloS one, e0124473 - ?. https://doi.org/10.1371/journal.pone.0124473

Toxoplasma gondii is an important protozoan parasite that infects all warm-blooded animals and causes opportunistic infections in immuno-compromised humans. Its closest relative, Neospora caninum, is an important veterinary pathogen that causes spont... Read More about Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features..