Non-random patterns in viral diversity (2015)
Journal Article
Anthony, S., Islam, A., Johnson, C., Navarrete-Macias, I., Liang, E., Jain, K., …Lipkin, W. (2015). Non-random patterns in viral diversity. Nature communications, https://doi.org/10.1038/ncomms9147

It is currently unclear whether changes in viral communities will ever be predictable. Here we investigate whether viral communities in wildlife are inherently structured (inferring predictability) by looking at whether communities are assembled thro... Read More about Non-random patterns in viral diversity.

Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides (2015)
Journal Article
Hart, S. R., Kenny, L. C., Myers, J. E., & Baker, P. N. (2015). Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides. International Journal of Mass Spectrometry, 391, 41-46. https://doi.org/10.1016/j.ijms.2015.08.025

Urine as a biofluid is commonly used in clinical diagnostics, including those performed during pregnancy. Urine is a rich source of polypeptides and polypeptidic protein degradation products, which have been filtered from blood plasma, thus urine has... Read More about Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides.

Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer. (2015)
Journal Article
Kitchen, M. O., Bryan, R. T., Haworth, K. E., Emes, R. D., Luscombe, C., Gommersall, L., …Farrell, W. E. (2015). Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer. PloS one, e0137003 - ?. https://doi.org/10.1371/journal.pone.0137003

INTRODUCTION: Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladder... Read More about Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer..

An optimized proportional-derivative controller for the human upper extremity with gravity (2015)
Journal Article
(2015). An optimized proportional-derivative controller for the human upper extremity with gravity. Journal of Biomechanics, 3692-3700. https://doi.org/10.1016/j.jbiomech.2015.08.016

When Functional Electrical Stimulation (FES) is used to restore movement in subjects with spinal cord injury (SCI), muscle stimulation patterns should be selected to generate accurate and efficient movements. Ideally, the controller for such a neurop... Read More about An optimized proportional-derivative controller for the human upper extremity with gravity.

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. (2015)
Journal Article
Maysami, S., Haley, M., Gorenkova, N., Krishnan, S., McColl, B., & Lawrence, C. (2015). Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. Journal of Neuroinflammation, 140 - ?. https://doi.org/10.1186/s12974-015-0359-8

BACKGROUND: Obesity increases the risk for ischaemic stroke and is associated with worse outcome clinically and experimentally. Most experimental studies have used genetic models of obesity. Here, a more clinically relevant model, diet-induced obesit... Read More about Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke..

Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner. (2015)
Journal Article
Dale, T. P., de Castro, A., Kuiper, N. J., Parkinson, E. K., & Forsyth, N. R. (2015). Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner. PloS one, 10(7), Article e0133745. https://doi.org/10.1371/journal.pone.0133745

BACKGROUND: Limited options for the treatment of cartilage damage have driven the development of tissue engineered or cell therapy alternatives reliant on ex vivo cell expansion. The study of chondrogenesis in primary cells is difficult due to progre... Read More about Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner..

Feasibility of using combined EMG and kinematic signals for prosthesis control: a simulation study using a virtual reality environment (2015)
Journal Article
Kyriacou. (2015). Feasibility of using combined EMG and kinematic signals for prosthesis control: a simulation study using a virtual reality environment. Journal of Electromyography and Kinesiology, 21-27. https://doi.org/10.1016/j.jelekin.2015.06.010

Transhumeral amputation has a significant effect on a person’s independence and quality of life. Myoelectric prostheses have the potential to restore upper limb function, however their use is currently limited due to lack of intuitive and natural con... Read More about Feasibility of using combined EMG and kinematic signals for prosthesis control: a simulation study using a virtual reality environment.

Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry (2015)
Journal Article
(2015). Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry. Rapid communications in mass spectrometry RCM, 1069 - 1079. https://doi.org/10.1002/rcm.7198

RATIONALE: It has been proposed that malondialdehyde (MDA) reflects free oxygen-radical lipid peroxidation and can be useful as a biomarker to track this process. For the analysis of MDA molecules in humid air by selected ion flow tube mass spectrome... Read More about Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry.

Cervical cancer is not just a young woman's disease (2015)
Journal Article
Redman, C., Sherman, S., Castanon, A., & Moss, E. (2015). Cervical cancer is not just a young woman's disease. BMJ, h2729 -?. https://doi.org/10.1136/bmj.h2729

Cervical screening programmes in many countries stop at around the age of 65 and much of the focus is often on younger women. For example, recent media campaigns in England and Wales have centred on lowering the age at first screening. Comparatively... Read More about Cervical cancer is not just a young woman's disease.

Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability (2015)
Journal Article
Walter, M., Kohli, N., Major, T., Fuller, H., Wright, K., Kuiper, J., & Johnson, W. (2015). Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. Journal of Stem Cells and Regenerative Medicine, 11(1), 18-24. https://doi.org/10.46582/jsrm.1101004

Mesenchymal stem cells (MSCs) stimulate angiogenesis within a wound environment and this effect is mediated through paracrine interactions with the endothelial cells present. Here we report that human MSC-conditioned medium (n=3 donors) significantly... Read More about Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability.

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion (2015)
Journal Article
Roberts, S., Evans, H., Wright, K., van Niekerk, L., Caterson, B., Richardson, J., …Kuiper, J. (2015). ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis and Cartilage, 23(9), 1622-1626. https://doi.org/10.1016/j.joca.2015.05.006

Objective
To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease.

Design
We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with di... Read More about ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion.

X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein (2015)
Journal Article
(2015). X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein. PloS one, e0123338 - e0123338. https://doi.org/10.1371/journal.pone.0123338

Phanta is a reversibly photoswitching chromoprotein (FF, 0.003), useful for pcFRET, that was isolated from a mutagenesis screen of the bright green fluorescent eCGP123 (FF, 0.8). We have investigated the contribution of substitutions at positions His... Read More about X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein.

Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features. (2015)
Journal Article
(2015). Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features. PloS one, e0124473 - ?. https://doi.org/10.1371/journal.pone.0124473

Toxoplasma gondii is an important protozoan parasite that infects all warm-blooded animals and causes opportunistic infections in immuno-compromised humans. Its closest relative, Neospora caninum, is an important veterinary pathogen that causes spont... Read More about Comprehensive evaluation of Toxoplasma gondii VEG and Neospora caninum LIV genomes with tachyzoite stage transcriptome and proteome defines novel transcript features..

Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis (2015)
Journal Article
Masood. (2015). Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis. International Journal of Systematic and Evolutionary Microbiology, 1335 - 1341. https://doi.org/10.1099/ijs.0.000108

A re-evaluation of the taxonomic position of two strains, 1383T and 2249, isolated from poppy seeds and tea leaves, which had been identified as Siccibacter turicensis (formerly Cronobacter zurichensis ), was carried out. The analysis included phenot... Read More about Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis.

SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells (2015)
Journal Article
Vicente, C., Andrade De Lima, M., Nader, H., & Toma, L. (2015). SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells. Journal of Experimental & Clinical Cancer Research, 34, 25--25. https://doi.org/10.1186/s13046-015-0141-x

Background
SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteoglycans (HSPGs) located on cell... Read More about SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells.

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin (2015)
Journal Article
(2015). Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin. PLoS Biology, e1002049 - e1002049. https://doi.org/10.1371/journal.pbio.1002049

Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transiti... Read More about Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.

Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA. (2015)
Journal Article
(2015). Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA. Genes, 484 - 499

It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biolog... Read More about Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA..

ProteoAnnotator--open source proteogenomics annotation software supporting PSI standards. (2014)
Journal Article
(2014). ProteoAnnotator--open source proteogenomics annotation software supporting PSI standards. Proteomics, 2731 - 2741. https://doi.org/10.1002/pmic.201400265

The recent massive increase in capability for sequencing genomes is producing enormous advances in our understanding of biological systems. However, there is a bottleneck in genome annotation--determining the structure of all transcribed genes. Exper... Read More about ProteoAnnotator--open source proteogenomics annotation software supporting PSI standards..

Rapid production of cyclonic spray chambers for inductively coupled plasma applications using low cost 3D printer technology (2014)
Journal Article
Thompson, D. F. (2014). Rapid production of cyclonic spray chambers for inductively coupled plasma applications using low cost 3D printer technology. Journal of Analytical Atomic Spectrometry, 2262 -2266. https://doi.org/10.1039/C4JA00291A

The development of low cost 3D printer technology is having a profound effect on everyday life. Over the past few years there have been many reports in the media detailing futuristic uses of this technology. Whilst the merits of these applications ar... Read More about Rapid production of cyclonic spray chambers for inductively coupled plasma applications using low cost 3D printer technology.

Mating competitiveness of sterile male Anopheles coluzzii in large cages (2014)
Journal Article
(2014). Mating competitiveness of sterile male Anopheles coluzzii in large cages. Malaria Journal, 460 -?. https://doi.org/10.1186/1475-2875-13-460

BACKGROUND: Understanding the factors that account for male mating competitiveness is critical to the development of the sterile insect technique (SIT). Here, the effects of partial sterilization with 90 Gy of radiation on sexual competitiveness of A... Read More about Mating competitiveness of sterile male Anopheles coluzzii in large cages.