Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function. (2014)
Journal Article
(2014). Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function. Journal of proteome research, 5120 - 5135. https://doi.org/10.1021/pr500556d

Viral pathogenesis in the infected cell is a balance between antiviral responses and subversion of host-cell processes. Many viral proteins specifically interact with host-cell proteins to promote virus biology. Understanding these interactions can l... Read More about Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function..

Occurrence and diversity of Giardia duodenalis assemblages in livestock in the UK. (2014)
Journal Article
(2014). Occurrence and diversity of Giardia duodenalis assemblages in livestock in the UK. Transboundary and Emerging Diseases, e60 - e67. https://doi.org/10.1111/tbed.12075

Giardia duodenalis is a common intestinal parasite in humans and a wide range of livestock species. It is a genetically heterogeneous parasite that has been characterized in seven distinct genetic assemblages or cryptic species, and molecular markers... Read More about Occurrence and diversity of Giardia duodenalis assemblages in livestock in the UK..

The use of a within-hive replication bioassay method to investigate the phagostimulatory effects of pollen, bee bread and pollen extracts, on free-flying honey bee colonies (2014)
Journal Article
Drijfhout. (2014). The use of a within-hive replication bioassay method to investigate the phagostimulatory effects of pollen, bee bread and pollen extracts, on free-flying honey bee colonies. Apidologie, 315 - 325. https://doi.org/10.1007/s13592-014-0324-z

A method for conducting multiple-choice bioassays, incorporating within-hive replication, is described and demonstrated here. This method has been used to study the influence of phagostimulants in pollens on food uptake within honey bee colonies. Exp... Read More about The use of a within-hive replication bioassay method to investigate the phagostimulatory effects of pollen, bee bread and pollen extracts, on free-flying honey bee colonies.

Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer (2014)
Journal Article
(2014). Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer. Rapid communications in mass spectrometry RCM, 1683 - 1690. https://doi.org/10.1002/rcm.6947

RATIONALE: The reactions of NO(+) with volatile organic compounds (VOCs) in Selective Reagent Ionization Time-of-Flight Mass Spectrometry (SRI-TOF-MS) reactors are relatively poorly known, inhibiting their use for trace gas analysis. The rationale fo... Read More about Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer.

Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity. (2014)
Journal Article
(2014). Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity. Journal of Proteomics, 230 - 245. https://doi.org/10.1016/j.jprot.2014.04.015

UNLABELLED: Profiling of protein species is important because gene polymorphisms, splice variations and post-translational modifications may combine and give rise to multiple protein species that have different effects on cellular function. Two-dimen... Read More about Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity..

Genotypic and phenotypic characteristics of Cronobacter species, with particular attention to the newly reclassified species Cronobacter helveticus, Cronobacter pulveris, and Cronobacter zurichensis (2014)
Journal Article
Masood. (2014). Genotypic and phenotypic characteristics of Cronobacter species, with particular attention to the newly reclassified species Cronobacter helveticus, Cronobacter pulveris, and Cronobacter zurichensis. Food Microbiology, 226 - 235. https://doi.org/10.1016/j.fm.2014.06.013

In 2013, Enterobacter helveticus, Enterobacter pulveris and Enterobacter turicensis, were reclassified as Cronobacter helveticus, Cronobacter pulveris and Cronobacter zurichensis, respectively. Previously these species had been used as negative contr... Read More about Genotypic and phenotypic characteristics of Cronobacter species, with particular attention to the newly reclassified species Cronobacter helveticus, Cronobacter pulveris, and Cronobacter zurichensis.

The SIFT and FALP techniques; applications to ionic and electronic reactions studies and their evolution to the SIFT-MS and FA-MS analytical methods (2014)
Journal Article
(2014). The SIFT and FALP techniques; applications to ionic and electronic reactions studies and their evolution to the SIFT-MS and FA-MS analytical methods. International Journal of Mass Spectrometry, 467 - 478. https://doi.org/10.1016/j.ijms.2014.05.016

Flow tube reactors coupled with quantitative mass spectrometry have made, and continue to make, major contributions to gas phase ion–molecule chemistry, to recombination and electron attachment studies and, most recently, to gas phase trace gas analy... Read More about The SIFT and FALP techniques; applications to ionic and electronic reactions studies and their evolution to the SIFT-MS and FA-MS analytical methods.

Changes in the distribution of red foxes (Vulpes vulpes) in urban areas in Great Britain: findings and limitations of a media-driven nationwide survey. (2014)
Journal Article
(2014). Changes in the distribution of red foxes (Vulpes vulpes) in urban areas in Great Britain: findings and limitations of a media-driven nationwide survey. PloS one, e99059 - ?. https://doi.org/10.1371/journal.pone.0099059

Urbanization is one of the major forms of habitat alteration occurring at the present time. Although this is typically deleterious to biodiversity, some species flourish within these human-modified landscapes, potentially leading to negative and/or p... Read More about Changes in the distribution of red foxes (Vulpes vulpes) in urban areas in Great Britain: findings and limitations of a media-driven nationwide survey..

The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. (2014)
Journal Article
(2014). The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. Nucleic acids research, 7113 - 7131. https://doi.org/10.1093/nar/gku322

Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood... Read More about The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction..

An investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix. (2014)
Journal Article
(2014). An investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix. PLoS Neglected Tropical Diseases, e2691 - ?. https://doi.org/10.1371/journal.pntd.0002691

BACKGROUND: Tsetse flies serve as biological vectors for several species of African trypanosomes. In order to survive, proliferate and establish a midgut infection, trypanosomes must cross the tsetse fly peritrophic matrix (PM), which is an acellular... Read More about An investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix..

Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument (2014)
Journal Article
(2014). Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument. International Journal of Mass Spectrometry, 23 - 31. https://doi.org/10.1016/j.ijms.2014.02.016

Product ion distributions for the reactions of NO(+) with 22 aldehydes involved in human physiology have been determined under the prevailing conditions of a selective reagent ionization time of flight mass spectrometry (SRI-TOF-MS) at an E/N in the... Read More about Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument.

Amplicon -based Metagenomic Analysis of Mixed Fungal Samples using Proton Release Amplicon Sequencing (2014)
Journal Article
Tonge, D., Pashley, C., & Gant, T. (2014). Amplicon -based Metagenomic Analysis of Mixed Fungal Samples using Proton Release Amplicon Sequencing. PloS one, https://doi.org/10.1371/journal.pone.0093849

Next generation sequencing technology has revolutionised microbiology by allowing concurrent analysis of whole microbial communities. Here we developed and verified similar methods for the analysis of fungal communities using a proton release sequenc... Read More about Amplicon -based Metagenomic Analysis of Mixed Fungal Samples using Proton Release Amplicon Sequencing.

Nesprins: tissue-specific expression of epsilon and other short isoforms (2014)
Journal Article
(2014). Nesprins: tissue-specific expression of epsilon and other short isoforms. PloS one, e94380 -?. https://doi.org/10.1371/journal.pone.0094380

Nesprin-1-giant and nesprin-2-giant regulate nuclear positioning by the interaction of their C-terminal KASH domains with nuclear membrane SUN proteins and their N-terminal calponin-homology domains with cytoskeletal actin. A number of short isoforms... Read More about Nesprins: tissue-specific expression of epsilon and other short isoforms.

Synthetic sex pheromone in a long-lasting lure attracts the visceral leishmaniasis vector, Lutzomyia longipalpis, for up to 12 weeks in Brazil (2014)
Journal Article
(2014). Synthetic sex pheromone in a long-lasting lure attracts the visceral leishmaniasis vector, Lutzomyia longipalpis, for up to 12 weeks in Brazil. PLoS Neglected Tropical Diseases, e2723 - ?. https://doi.org/10.1371/journal.pntd.0002723

Current control methodologies have not prevented the spread of visceral leishmaniasis (VL) across Brazil. Here, we describe the development of a new tool for controlling the sand fly vector of the disease: a long-lasting lure, which releases a synthe... Read More about Synthetic sex pheromone in a long-lasting lure attracts the visceral leishmaniasis vector, Lutzomyia longipalpis, for up to 12 weeks in Brazil.

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice (2014)
Journal Article
Beard, P. (2014). Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. Journal of Leukocyte Biology, 265 - 274. https://doi.org/10.1189/jlb.2A0114-006R

We investigated the role of CSF1R signaling in adult mice using prolonged treatment with anti-CSF1R antibody. Mutation of the CSF1 gene in the op/op mouse produces numerous developmental abnormalities. Mutation of the CSF1R has an even more penetrant... Read More about Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry (2014)
Journal Article
Beard, P. (2014). TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry. Journal of Virology, 3664 - 3677. https://doi.org/10.1128/JVI.03013-13

<jats:title>ABSTRACT</jats:title> <jats:p> Tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2) is a pivotal intracellular mediator of signaling pathways downstream of TNFR1 and -2 with known pro- and antiviral effects. We investigated i... Read More about TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry.

Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide ß-amyloid. (2014)
Journal Article
Telling, & Everett. (2014). Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide ß-amyloid. Inorganic Chemistry, 2803 - 2809. https://doi.org/10.1021/ic402406g

Recent work has demonstrated increased levels of redox-active iron biominerals in Alzheimer's disease (AD) tissue. However, the origin, nature, and role of iron in AD pathology remains unclear. Using X-ray absorption, X-ray microspectroscopy, and ele... Read More about Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide ß-amyloid..

Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis. (2014)
Journal Article
Mamas, M., & Nolan, J. (2014). Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis. Open Heart, e000021 -?. https://doi.org/10.1136/openhrt-2013-000021

OBJECTIVES: To examine the relationship between periprocedural bleeding complications and major adverse cardiovascular events (MACEs) and mortality outcomes following percutaneous coronary intervention (PCI) and study differences in the prognostic im... Read More about Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis..

Differential effects of inbreeding and selection on male reproductive phenotype associated with the colonization and laboratory maintenance of Anopheles gambiae. (2014)
Journal Article
(2014). Differential effects of inbreeding and selection on male reproductive phenotype associated with the colonization and laboratory maintenance of Anopheles gambiae. Malaria Journal, 19 -?. https://doi.org/10.1186/1475-2875-13-19

BACKGROUND: Effective mating between laboratory-reared males and wild females is paramount to the success of vector control strategies aiming to decrease disease transmission via the release of sterile or genetically modified male mosquitoes. However... Read More about Differential effects of inbreeding and selection on male reproductive phenotype associated with the colonization and laboratory maintenance of Anopheles gambiae..

Genetic and environmental factors associated with laboratory rearing affect survival and assortative mating but not overall mating success in Anopheles gambiae sensu stricto. (2013)
Journal Article
(2013). Genetic and environmental factors associated with laboratory rearing affect survival and assortative mating but not overall mating success in Anopheles gambiae sensu stricto. PloS one, e82631 - ?. https://doi.org/10.1371/journal.pone.0082631

Anopheles gambiae sensu stricto, the main vector of malaria in Africa, is characterized by its vast geographical range and complex population structure. Assortative mating amongst the reproductively isolated cryptic forms that co-occur in many areas... Read More about Genetic and environmental factors associated with laboratory rearing affect survival and assortative mating but not overall mating success in Anopheles gambiae sensu stricto..