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Aluminium in human brain tissue: how much is too much? (2019)
Journal Article
(2019). Aluminium in human brain tissue: how much is too much?. Journal of Biological Inorganic Chemistry, 1279-1282. https://doi.org/10.1007/s00775-019-01710-0

A burgeoning body of research confirms and affirms the presence of aluminium in human brain tissue. Recently, the first data on aluminium content of brain tissue from donors with diagnoses of familial Alzheimer's disease, autism spectrum disorder, mu... Read More about Aluminium in human brain tissue: how much is too much?.

Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio) (2019)
Journal Article
(2019). Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio). Journal of Fish Biology, https://doi.org/10.1111/jfb.14222

ß-glucans are frequently included in the diet of healthy common carp Cyprinus carpio as a pre-emptive measure for combatting disease. In order to study the effect this has on the relationship between the gut bacteria and host immune response, carp we... Read More about Effect of ß-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio).

The Metabolic Fate and Effects of 2-Bromophenol in Male Sprague-Dawley Rats. (2019)
Journal Article
Thompson, D. F. (2019). The Metabolic Fate and Effects of 2-Bromophenol in Male Sprague-Dawley Rats. Xenobiotica, 1352-1359. https://doi.org/10.1080/00498254.2018.1559376

1. The metabolic fate and urinary excretion of 2-bromophenol, a phenolic metabolite of bromobenzene, was investigated in male Sprague Dawley rats following single intraperitoneal doses at either 0, 100 or 200?mg/kg. 2. Urine was collected for seven d... Read More about The Metabolic Fate and Effects of 2-Bromophenol in Male Sprague-Dawley Rats..

Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy (2019)
Journal Article
Šoltić, D., Shorrock, H. K., Allardyce, H., Wilson, E. L., Holt, I., Synowsky, S. A., …Fuller, H. (2019). Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy. Human Molecular Genetics, 3515-3527. https://doi.org/10.1093/hmg/ddz195

Cardiac pathology is emerging as a prominent systemic feature of spinal muscular atrophy (SMA), but little is known about the underlying molecular pathways. Using quantitative proteomics analysis, we demonstrate widespread molecular defects in heart... Read More about Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy.

Clastic injectites, internal structures and flow regime during injection: The Sea Lion Injectite System, North Falkland Basin (2019)
Journal Article
Dodd, T., McCarthy, D., & Clarke, S. (2019). Clastic injectites, internal structures and flow regime during injection: The Sea Lion Injectite System, North Falkland Basin. Sedimentology, https://doi.org/10.1111/sed.12672

This paper details and describes a suite of 143 sub-seismic-scale clastic injectites encountered within the early Cretaceous, early post-rift of the deep-lacustrine North Falkland Basin. The injectites, referred to here as the Sea Lion Injectite Syst... Read More about Clastic injectites, internal structures and flow regime during injection: The Sea Lion Injectite System, North Falkland Basin.

The relative rate of kill of the MMV Malaria Box compounds provide links to the mode of antimalarial action and highlight scaffolds of medicinal chemistry interest (2019)
Journal Article
Horrocks. (2019). The relative rate of kill of the MMV Malaria Box compounds provide links to the mode of antimalarial action and highlight scaffolds of medicinal chemistry interest. Journal of Antimicrobial Chemotherapy, 362-370. https://doi.org/10.1093/jac/dkz443

Objectives: Rapid rate-of-kill (RoK) is a key parameter in the target candidate profile 1 (TCP1) for the next-generation antimalarial drugs for uncomplicated malaria, termed Single Encounter Radical Cure and Prophylaxis (SERCaP). TCP1 aims to rapidly... Read More about The relative rate of kill of the MMV Malaria Box compounds provide links to the mode of antimalarial action and highlight scaffolds of medicinal chemistry interest.

Experienced males recognise and avoid mating with non-virgin females in the western flower thrips (2019)
Journal Article
Kirk. (2019). Experienced males recognise and avoid mating with non-virgin females in the western flower thrips. PloS one, https://doi.org/10.1371/journal.pone.0224115

The western flower thrips Frankliniella occidentalis (Thysanoptera: Thripidae) is a major insect pest on a wide range of crops throughout the world. There are several unexplained aspects of the mating behaviour, particularly in relation to male-male... Read More about Experienced males recognise and avoid mating with non-virgin females in the western flower thrips.

Overwintering of the western flower thrips in outdoor strawberry crops (2019)
Journal Article
Kirk. (2019). Overwintering of the western flower thrips in outdoor strawberry crops. Journal of Pest Science, https://doi.org/10.1007/s10340-019-01163-z

The western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae), is a major pest of semi-protected strawberry crops in the UK. These crops are grown outdoors but sheltered by clear polythene tunnels during the growing seaso... Read More about Overwintering of the western flower thrips in outdoor strawberry crops.

Tools for the Quality Control of Pharmaceutical Heparin. (2019)
Journal Article
Devlin, A., Mycroft-West, C., Procter, P., Cooper, L., Guimond, S., Andrade De Lima, M., …Skidmore, M. (2019). Tools for the Quality Control of Pharmaceutical Heparin. Medicina, 55, 636 - 636. https://doi.org/10.3390/medicina55100636

Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced pharmaceutical agents used clinically. Heparin possesses a structural order with up to four levels of complexity. These levels are subject to change bas... Read More about Tools for the Quality Control of Pharmaceutical Heparin..

A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells. (2019)
Journal Article
(2019). A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells. Proceedings of the National Academy of Sciences of the United States of America, 20743-20749. https://doi.org/10.1073/pnas.1908058116

Mechanoelectrical transducer (MET) currents were recorded from cochlear hair cells in mice with mutations of transmembrane channel-like protein TMC1 to study the effects on MET channel properties. We characterized a Tmc1 mouse with a single-amino-aci... Read More about A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells..

Semi-field and indoor setups to study malaria mosquito swarming behavior (2019)
Journal Article
(2019). Semi-field and indoor setups to study malaria mosquito swarming behavior. Parasites and Vectors, 446 -?. https://doi.org/10.1186/s13071-019-3688-0

BACKGROUND
The recent resurgence of interest in sterile insect techniques to control vector mosquitoes has renewed interest in novel methods for observing mating behavior. Malarial vectors of the Anopheles gambiae complex are known to mate in swarms... Read More about Semi-field and indoor setups to study malaria mosquito swarming behavior.

Phenotypic Plasticity of Nest-Mate Recognition Cues in Formica exsecta Ants. (2019)
Journal Article
Martin, S. J., Drijfhout, F. P., & Hart, A. G. (2019). Phenotypic Plasticity of Nest-Mate Recognition Cues in Formica exsecta Ants. Journal of Chemical Ecology, 735 -740. https://doi.org/10.1007/s10886-019-01103-2

It is well established that many ant species have evolved qualitatively distinct species-specific chemical profile that are stable over large geographical distances. Within these species profiles quantitative variations in the chemical profile allows... Read More about Phenotypic Plasticity of Nest-Mate Recognition Cues in Formica exsecta Ants..

BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives. (2019)
Journal Article
(2019). BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives. Journal of Synchrotron Radiation, 1843 -1850. https://doi.org/10.1107/S1600577519008981

Being able to visualize biology at the molecular level is essential for our understanding of the world. A structural biology approach reveals the molecular basis of disease processes and can guide the design of new drugs as well as aid in the optimiz... Read More about BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives..

Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin. (2019)
Journal Article
(2019). Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin. Histochemistry and Cell Biology, https://doi.org/10.1007/s00418-019-01809-0

Aluminium is biologically reactive and its ability to potentiate the immune response has driven its inclusion in both veterinary and human vaccines. Consequently, the need for unequivocal visualisation of aluminium in vivo has created a focused resea... Read More about Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin..

Anosmic migrating songbirds demonstrate a compensatory response following long-distance translocation: a radio-tracking study (2019)
Journal Article
Kishkinev, D., Anashina, A., Ishchenko, I., & Holland, R. A. (2019). Anosmic migrating songbirds demonstrate a compensatory response following long-distance translocation: a radio-tracking study. Journal of Ornithology, https://doi.org/10.1007/s10336-019-01698-z

Several studies have shown that experienced night-migratory songbirds can determine their position, but it has remained a mystery which cues and sensory mechanisms they use, in particular, those used to determine longitude (east–west position). One p... Read More about Anosmic migrating songbirds demonstrate a compensatory response following long-distance translocation: a radio-tracking study.

Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts (2019)
Journal Article
Horrocks. (2019). Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts. Frontiers in Plant Science, https://doi.org/10.3389/fpls.2019.00984

Artemisinin, a sesquiterpene lactone produced by Artemisia annua glandular secretory trichomes, is the active ingredient in the most effective treatment for uncomplicated malaria caused by Plasmodium falciparum parasites. Other metabolites in A. annu... Read More about Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts.

Current versus future reproductive investment adaptive responses in adult Anopheles coluzzii malaria mosquitoes: hydric-stressed males give it all. (2019)
Journal Article
(2019). Current versus future reproductive investment adaptive responses in adult Anopheles coluzzii malaria mosquitoes: hydric-stressed males give it all. Parasites and Vectors, 377 - ?. https://doi.org/10.1186/s13071-019-3608-3

BACKGROUND:
Life history theory predicts that an individual's current reproductive investment should depend on its future reproductive value. A variety of intrinsic biotic and extrinsic factors influence reproductive value, including age, health st... Read More about Current versus future reproductive investment adaptive responses in adult Anopheles coluzzii malaria mosquitoes: hydric-stressed males give it all..

Associative learning and memory retention of nectar yeast volatiles in a generalist parasitoid (2019)
Journal Article
(2019). Associative learning and memory retention of nectar yeast volatiles in a generalist parasitoid. Animal Behaviour, 137 - 146. https://doi.org/10.1016/j.anbehav.2019.05.006

Understanding how animals learn is crucial to interpreting animal behaviour. Flower-visiting insects, such as bees and parasitoids, are excellent animal models to study visual and olfactory learning, including memory phenomena. The diversity of resou... Read More about Associative learning and memory retention of nectar yeast volatiles in a generalist parasitoid.

An insight into advances in fisheries biology, genetics and genomics of African tilapia species of interest in aquaculture (2019)
Journal Article
(2019). An insight into advances in fisheries biology, genetics and genomics of African tilapia species of interest in aquaculture. https://doi.org/10.1016/j.aqrep.2019.100188

Morphological identification of tilapia species is complicated by extensive intraspecific variation of morphological characters used for classical identification. To address this obstacle, use of molecular techniques as additional tools for identific... Read More about An insight into advances in fisheries biology, genetics and genomics of African tilapia species of interest in aquaculture.