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Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1 (2018)
Journal Article
Drizou, F., Bruce, T. J. A., Ray, R. V., & Graham, N. S. (2018). Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1. Frontiers in Plant Science, 9, Article ARTN 1903. https://doi.org/10.3389/fpls.2018.01903

Activation of plant defense pathways can be influenced by the presence of different species of attacking organisms. Understanding the complicated interactions triggering plant defense mechanisms is of great interest as it may allow the development of... Read More about Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1.

Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin (2018)
Journal Article
(2018). Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin. Communications Biology, https://doi.org/10.1038/s42003-018-0203-7

Plasma-membrane Ca(2+)-ATPases expel Ca(2+) from the cytoplasm and are key regulators of Ca(2+) homeostasis in eukaryotes. They are autoinhibited under low Ca(2+) concentrations. Calmodulin (CaM)-binding to a unique regulatory domain releases the aut... Read More about Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin.

RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge? (2018)
Journal Article
(2018). RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?. Viruses, https://doi.org/10.3390/v10110600

RNA viruses replicate with low fidelity due to the error-prone nature of the RNA-dependent RNA polymerase, which generates approximately one mutation per round of genome replication. Due to the large population sizes produced by RNA viruses during re... Read More about RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?.

Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris) (2018)
Journal Article
(2018). Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris). PloS one, https://doi.org/10.1371/journal.pone.0204612

Gut microbial communities are critical for the health of many insect species. However, little is known about how gut microbial communities respond to anthropogenic changes and how such changes affect host-pathogen interactions. In this study, we used... Read More about Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris).

Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density. (2018)
Journal Article
(2018). Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density. Malaria Journal, 377. https://doi.org/10.1186/s12936-018-2530-z

BACKGROUND: In a context of increasing resistance of both vectors toward main classes of insecticides used in public health and parasites toward anti-malarial drugs, development of new and complementary molecules or control approaches is fundamental... Read More about Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density..

Relationship Between Hydrocarbon Composition on the Cuticle of Melipona quadrifasciata (Hymenoptera: Apidae) Workers and the Secretion of the Cephalic Salivary Glands (2018)
Journal Article
Poiani, S. B., Morgan, E., Drijfhout, F. P., & Cruz-Landim, C. (2018). Relationship Between Hydrocarbon Composition on the Cuticle of Melipona quadrifasciata (Hymenoptera: Apidae) Workers and the Secretion of the Cephalic Salivary Glands. Sociobiology, 671 - 678. https://doi.org/10.13102/sociobiology.v65i4.3384

Since chemical communication is pivotal for social insect success, the present paper aimed to quantify and qualify the chemical compounds that might have pheromonal role in both cephalic salivary gland and epicuticle of workers of Melipona quadrifasc... Read More about Relationship Between Hydrocarbon Composition on the Cuticle of Melipona quadrifasciata (Hymenoptera: Apidae) Workers and the Secretion of the Cephalic Salivary Glands.

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. (2018)
Journal Article
(2018). Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature communications, 4015 - ?. https://doi.org/10.1038/s41467-018-06307-w

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are ope... Read More about Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation..

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation (2018)
Journal Article
(2018). Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature communications, https://doi.org/10.1038/s41467-018-06307

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are ope... Read More about Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age (2018)
Journal Article
Martins, D., de Medeiros, V., Wajchenberg, M., Paredes-Gamero, E., Andrade De Lima, M., Reginato, R., …Faloppa, F. (2018). Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age. PloS one, 13, e0203932--e0203932. https://doi.org/10.1371/journal.pone.0203932

Objective
This study evaluates molecular, nutritional and biochemical alterations in human intervertebral discs between middle and old age.

Methods
Twenty-eight human lumbar intervertebral discs from donors were evaluated and separated into two... Read More about Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age.

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3 (2018)
Journal Article
(2018). Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3. Nature communications, https://doi.org/10.1038/s41467-018-06096-2

Conjugation is fundamental for the acquisition of new genetic traits and the development of antibiotic resistance in pathogenic organisms. Here, we show that a hypothetical Clostridium perfringens protein, TcpK, which is encoded by the tetracycline r... Read More about Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3.

The perplexing PEXEL protein secretory pathway (2018)
Journal Article
Russo. (2018). The perplexing PEXEL protein secretory pathway. Nature Reviews Microbiology, 969 - 970. https://doi.org/10.1038/s41564-018-0235-2

Plasmodium parasites possess a unique PEXEL sorting pathway to deliver secretory proteins into the host cells in which they reside. A new study shows the existence of independent sorting/entry complexes to detect and deliver PEXEL proteins into the p... Read More about The perplexing PEXEL protein secretory pathway.

The role of heparan sulfate in host macrophage infection by Leishmania species (2018)
Journal Article
Maciej-Hulme, M., Skidmore, M., & Price, H. (2018). The role of heparan sulfate in host macrophage infection by Leishmania species. Transactions, 46(4), 789-796. https://doi.org/10.1042/BST20170398

The leishmaniases are a group of neglected tropical diseases caused by parasites from the Leishmania genus. More than 20 Leishmania species are responsible for human disease, causing a broad spectrum of symptoms ranging from cutaneous lesions to a fa... Read More about The role of heparan sulfate in host macrophage infection by Leishmania species.

Maize Chlorotic Mottle Virus Induces Changes in Host Plant Volatiles that Attract Vector Thrips Species (2018)
Journal Article
Bruce, T., Subramanian, S., Mwando, N., Tamiru, A., Nyasani, J., Obonyo, M., & Caulfield, J. (2018). Maize Chlorotic Mottle Virus Induces Changes in Host Plant Volatiles that Attract Vector Thrips Species. Journal of Chemical Ecology, 681-689. https://doi.org/10.1007/s10886-018-0973-x

Maize lethal necrosis is one of the most devastating diseases of maize causing yield losses reaching up to 90% in sub-Saharan Africa. The disease is caused by a combination of maize chlorotic mottle virus (MCMV) and any one of cereal viruses in the P... Read More about Maize Chlorotic Mottle Virus Induces Changes in Host Plant Volatiles that Attract Vector Thrips Species.

Is the Salivary Gland Associated with Honey Bee Recognition Compounds in Worker Honey Bees (Apis mellifera)? (2018)
Journal Article
Martin, S. J., Correia-Oliveira, M. E., Shemilt, S., & Drijfhout, F. (2018). Is the Salivary Gland Associated with Honey Bee Recognition Compounds in Worker Honey Bees (Apis mellifera)?. Journal of Chemical Ecology, 44, 650-657. https://doi.org/10.1007/s10886-018-0975-8

Cuticular hydrocarbons (CHCs) function as recognition compounds with the best evidence coming from social insects such as ants and honey bees. The major exocrine gland involved in hydrocarbon storage in ants is the post-pharyngeal gland (PPG) in the... Read More about Is the Salivary Gland Associated with Honey Bee Recognition Compounds in Worker Honey Bees (Apis mellifera)?.

Sweet Scents: Nectar Specialist Yeasts Enhance Nectar Attraction of a Generalist Aphid Parasitoid Without Affecting Survival (2018)
Journal Article
(2018). Sweet Scents: Nectar Specialist Yeasts Enhance Nectar Attraction of a Generalist Aphid Parasitoid Without Affecting Survival. Frontiers in Plant Science, https://doi.org/10.3389/fpls.2018.01009

Floral nectar is commonly inhabited by microorganisms, mostly yeasts and bacteria, which can have a strong impact on nectar chemistry and scent. Yet, little is known about the effects of nectar microbes on the behavior and survival of insects belongi... Read More about Sweet Scents: Nectar Specialist Yeasts Enhance Nectar Attraction of a Generalist Aphid Parasitoid Without Affecting Survival.

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. (2018)
Journal Article
Price, H., Berry, S., Hameed, H., Thomason, A., Maciej-Hulme, M., Saif Abou-Akkada, S., & Horrocks, P. (2018). Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. PLoS Neglected Tropical Diseases, 12(7), Article e0006639 . https://doi.org/10.1371/journal.pntd.0006639

The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging. New th... Read More about Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays..

Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages (2018)
Journal Article
(2018). Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages. Proteomics, https://doi.org/10.1002/pmic.201800132

Recently, 3D small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic the structura... Read More about Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages.