A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2025)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Stokes-Fisher, J., Peffers, M., El Masri, W., …Wright, K. (2025). A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome. Journal of Neurotrauma, 42(3-4), https://doi.org/10.1101/2022.07.12.499696

Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues with the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult to predict, particularly... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. (2023)
Journal Article
Hulme, C., & Wright, K. (2023). Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. American Journal of Sports Medicine, 51(6), 1422-1433. https://doi.org/10.1177/03635465231156616

BACKGROUND: Stratification is required to ensure that only patients likely to benefit receive autologous chondrocyte implantation (ACI). It would be advantageous to identify biomarkers to predict ACI outcome that are measurable in blood, avoiding the... Read More about Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening..

Investigation of the blood proteome in response to spinal cord injury in rodent models (2021)
Journal Article
Hulme, C. H., Fuller, H. R., Riddell, J., Shirran, S. L., Botting, C. H., Osman, A., & Wright, K. T. (2022). Investigation of the blood proteome in response to spinal cord injury in rodent models. Spinal Cord, 60(4), 320-325. https://doi.org/10.1038/s41393-021-00692-8

STUDY DESIGN: Explanatory and Mechanistic Study
OBJECTIVES: A better understanding of the ‘whole-body’ response following spinal cord injury (SCI) is needed to guide future research aimed at developing novel therapeutic interventions and identifying... Read More about Investigation of the blood proteome in response to spinal cord injury in rodent models.

Altered Acute Phase Response (APR) signalling following cartilage harvest can be identified in the plasma of ‘non-Responder’ Patients to Autologous Chondrocyte Implantation (2021)
Presentation / Conference
Hulme. (2021, September). Altered Acute Phase Response (APR) signalling following cartilage harvest can be identified in the plasma of ‘non-Responder’ Patients to Autologous Chondrocyte Implantation. Presented at British Orthopaedic Research Society (BORS) 2021, Virtual (Hosted by Imperial College London)

Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy (2021)
Journal Article
Hulme, & Wright Bevans. (2021). Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. American Journal of Sports Medicine, 1512-1523

Background: Biomarkers are needed to predict clinical outcome for microfracture and osteotomy surgeries to ensure patients can be better stratified to receive the most appropriate treatment.
Hypothesis/purpose: To identify novel biomarker candidate... Read More about Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy.

Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury (2020)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Osman, A., Roy Chowdhury, J., Kumar, N., …Wright, K. (2020). Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury. Journal of Neurotrauma, 38(3), https://doi.org/10.1089/neu.2020.7144

Neurological outcomes following spinal cord injury (SCI) are currently difficult to predict. Whilst the initial American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade can give an estimate of outcome, the high remaining degree of uncer... Read More about Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury.

The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes (2020)
Journal Article
Mennan, Hulme, & Wright, K. (2020). The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes. Osteoarthritis and Cartilage Open, 1-8. https://doi.org/10.1016/j.ocarto.2020.100039

Objective The synovial fluid (SF) of patients with focal cartilage defects contains a population of poorly characterised cells that could have pathophysiological implications in early osteoarthritis and joint tissue repair. We have examined the cells... Read More about The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes.

The effect of high glucose on lipid metabolism in the human placenta (2019)
Journal Article
Hulme. (2019). The effect of high glucose on lipid metabolism in the human placenta. Scientific reports, https://doi.org/10.1038/s41598-019-50626-x

Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose co... Read More about The effect of high glucose on lipid metabolism in the human placenta.

Cell Therapy for Cartilage Repair
Journal Article
McCarthy, H., Perry, J., Hulme, C., Mennan, C., & Wright, K. (in press). Cell Therapy for Cartilage Repair

Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating... Read More about Cell Therapy for Cartilage Repair.

Juvenile Chondrocytes: Novel Alternatives for Allogeneic Cell Therapy?
Presentation / Conference
Hulme, C., & Wright, K. Juvenile Chondrocytes: Novel Alternatives for Allogeneic Cell Therapy?. Presented at International Cartilage Regeneration and Joint Preservation Society (ICRS) World Congress 2022

Purpose
Development of novel allogeneic chondrocyte therapies are needed to provide a more widespread, cost-effective cartilage treatment option. Here we investigate the potential of juvenile cartilage sources for allogeneic chondrocyte manufactur... Read More about Juvenile Chondrocytes: Novel Alternatives for Allogeneic Cell Therapy?.