Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology (2025)
Journal Article
Erbay, M. I., Manubolu, V. S., Stein-Merlob, A. F., Ferencik, M., Mamas, M. A., Lopez-Mattei, J., …Yang, E. H. (2025). Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology. Current Cardiology Reports, 27(1), 51. https://doi.org/10.1007/s11886-025-02206-x

Purpose of Review: Cardiovascular computed tomography (CCT) is a versatile, readily available, and non-invasive imaging tool with high-resolution capabilities in many cardiovascular diseases (CVD). Our review explains the increased risk of CVD among... Read More about Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology.

The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses. (2024)
Journal Article
Galimzhanov, A., Tun, H. N., Sabitov, Y., Perone, F., Kursat, T. M., Tenekecioglu, E., & Mamas, M. A. (in press). The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses. European Journal of Clinical Investigation, Article e14295. https://doi.org/10.1111/eci.14295

Mean platelet volume (MPV) is a widely available laboratory index, however its prognostic significance in patients with coronary artery disease (CAD) is still unclear. We intended to investigate and pool the evidence on the prognostic utility of admi... Read More about The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses..

Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T). (2024)
Journal Article
Miranda, R. N., Qiu, F., Manoragavan, R., Austin, P. C., Naimark, D. M. J., Fremes, S. E., …Wijeysundera, H. C. (2024). Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T). Journal of the American Heart Association, 13(5), Article e033768. https://doi.org/10.1161/JAHA.123.033768

Transcatheter aortic valve implantation (TAVI) has seen indication expansion and thus exponential growth in demand over the past decade. In many jurisdictions, the growing demand has outpaced capacity, increasing wait times and preprocedural adverse... Read More about Transcatheter Aortic Valve Implantation Wait-Time Management: Derivation and Validation of the Canadian TAVI Triage Tool (CAN3T)..

The invasive investigation of INOCA in the coronary catheterization lab (2024)
Journal Article
Burgess, S. N., & Mamas, M. A. (2024). The invasive investigation of INOCA in the coronary catheterization lab. American Heart Journal Plus: Cardiology Research and Practice, 38, Article 100365. https://doi.org/10.1016/j.ahjo.2024.100365

Over half of all patients with angina have no angiographically demonstratable obstructive coronary disease, with a significant proportion of these patients having undiagnosed microvascular dysfunction and/or vasospastic angina. In chronic coronary sy... Read More about The invasive investigation of INOCA in the coronary catheterization lab.

Mortality across treatment strategies in intermediate-to-high risk pulmonary embolism in the modern era: A meta-analysis of observational studies and RCTs. (2023)
Journal Article
Iannaccone, M., Franchin, L., Russo, F., Botti, G., Castellano, D., Montorfano, M., …Chieffo, A. (2023). Mortality across treatment strategies in intermediate-to-high risk pulmonary embolism in the modern era: A meta-analysis of observational studies and RCTs. International Journal of Cardiology, 387, Article 131127. https://doi.org/10.1016/j.ijcard.2023.131127

Pulmonary embolism (PE) represents one of the leading causes of death worldwide and mainly treated with medical management, although the utility of more invasive approaches has emerged more recently. This meta-analysis aims to evaluate the 30-day mor... Read More about Mortality across treatment strategies in intermediate-to-high risk pulmonary embolism in the modern era: A meta-analysis of observational studies and RCTs..

Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study (2023)
Journal Article
Jordan, K. P., Rathod-Mistry, T., van der Windt, D. A., Bailey, J., Chen, Y., Clarson, L., …Mamas, M. A. (2023). Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study. European Journal of Preventive Cardiology, 30(11), 1151-1161. https://doi.org/10.1093/eurjpc/zwad055

BACKGROUND: Most adults presenting in primary care with chest pain symptoms will not receive a diagnosis ("unattributed" chest pain) but are at increased risk of cardiovascular events. AIM: To assess within patients with unattributed chest pain, risk... Read More about Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study.

Role of Cardiac Magnetic Resonance Imaging in the Evaluation of MINOCA (2023)
Journal Article
Mamas. (2023). Role of Cardiac Magnetic Resonance Imaging in the Evaluation of MINOCA. Journal of Clinical Medicine, 2017 - 2017. https://doi.org/10.3390/jcm12052017

<jats:p>Myocardial infarction with Non Obstructive Coronary Arteries (MINOCA) is defined by patients presenting with signs and symptoms similar to acute myocardial infarction, but are found to have non-obstructive coronary arteries angiography. What... Read More about Role of Cardiac Magnetic Resonance Imaging in the Evaluation of MINOCA.

Comparison of care and outcomes for myocardial infarction by heart failure status between United Kingdom and Japan. (2023)
Journal Article
Rashid, Mamas, & Dafaalla. (2023). Comparison of care and outcomes for myocardial infarction by heart failure status between United Kingdom and Japan. ESC Heart Failure, https://doi.org/10.1002/ehf2.14290

AIMS: Prognosis for ST-segment elevation myocardial infarction (STEMI) is worse when heart failure is present on admission. Understanding clinical practice in different health systems can identify areas for quality improvement initiatives to improve... Read More about Comparison of care and outcomes for myocardial infarction by heart failure status between United Kingdom and Japan..

SCAI Expert Consensus Statement on Percutaneous Coronary Intervention Without On-Site Surgical Backup (2023)
Journal Article
Mamas. (2023). SCAI Expert Consensus Statement on Percutaneous Coronary Intervention Without On-Site Surgical Backup. https://doi.org/10.1016/j.jscai.2022.100560

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019 (2023)
Journal Article
Mamas. (2023). The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019. Metabolism, 141, Article 155402. https://doi.org/10.1016/j.metabol.2023.155402

Background: A significant proportion of premature deaths globally are related to metabolic diseases in young adults. We examined the global trends and mortality of metabolic diseases in individuals aged below 40 years using data from the Global Burde... Read More about The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019.

Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry (2022)
Journal Article
Mamas. (2022). Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry. European Heart Journal, 5020-5032. https://doi.org/10.1093/eurheartj/ehac511

Background and Aims Postinfarction ventricular septal defect (PIVSD) is a mechanical complication of myocardial infarction (MI) with a poor prognosis. Surgical repair is the mainstay of treatment, although percutaneous closure is increasingly underta... Read More about Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry.

Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes (2022)
Journal Article
Mamas. (2022). Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes. Scientific reports, https://doi.org/10.1038/s41598-022-04929-1

<jats:title>Abstract</jats:title><jats:p>Mitochondrial dysfunction is a feature of type I and type II diabetes, but there is a lack of consistency between reports and links to disease development. We aimed to investigate if mitochondrial structure–fu... Read More about Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes.

Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis. (2022)
Journal Article
Mamas, & Rashid. (2022). Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis. https://doi.org/10.1016/j.ijcha.2022.101135

Background: Individuals who present with STEMI without the standard cardiovascular risk factors (SMuRFs) of diabetes, hypercholesterolemia, hypertension, and smoking, coined SMuRF-less are not uncommon. Little is known about their outcomes as a cohor... Read More about Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis..

Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. (2022)
Journal Article
Wright, F. L., Cheema, K., Goldacre, R., Hall, N., Herz, N., Islam, N., …Banerjee, A. (2023). Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. European Heart Journal - Quality of Care and Clinical Outcomes, 9(4), 377-388. https://doi.org/10.1093/ehjqcco/qcac077

Background
Although morbidity and mortality from COVID-19 have been widely reported, the indirect effects of the pandemic beyond 2020 on other major diseases and health service activity have not been well described.

Methods and results
Analyses... Read More about Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries..

Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States. (2022)
Journal Article
Rashid, & Mamas. (2022). Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States. Journal of Palliative Care, 8258597221136733 - ?. https://doi.org/10.1177/08258597221136733

Objective: Limited data exist around the receipt of palliative care (PC) in patients hospitalized with common chronic conditions. We studied the independent predictors, temporal trends in rates of PC utilization in patients hospitalized with acute ex... Read More about Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States..

Prevalence, characteristics and mortality of cancer patients undergoing pericardiocentesis in the United States between 2004 and 2017. (2022)
Journal Article
Mamas, & Rashid. (2022). Prevalence, characteristics and mortality of cancer patients undergoing pericardiocentesis in the United States between 2004 and 2017. Cancer Medicine, https://doi.org/10.1002/cam4.5373

BACKGROUND: Pericardiocentesis is undertaken in patients with cancer for diagnostic and therapeutic purposes. However, there are limited data on the frequency, characteristics and mortality of patients with different cancers undergoing pericardiocent... Read More about Prevalence, characteristics and mortality of cancer patients undergoing pericardiocentesis in the United States between 2004 and 2017..

Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs. (2022)
Journal Article
Mamas. (2022). Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs. Journal of Cardiovascular Computed Tomography, https://doi.org/10.1016/j.jcct.2022.09.005

BACKGROUND: FFRCT assesses the functional significance of lesions seen on CTCA, and may be a more efficient approach to chest pain evaluation. The FORECAST randomized trial found no significant difference in costs within the UK National Health Servic... Read More about Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs..

Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies (2022)
Journal Article
Doolub, G., & Mamas, M. A. (2022). Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies. Journal of Personalized Medicine, 12(9), Article 1372. https://doi.org/10.3390/jpm12091372

The number of cancer survivors in the United States is projected to increase by 31% by 2030. With advances in early screening, diagnosis and therapeutic strategies, a steadily increasing number of patients are surviving cancer. Coronary artery diseas... Read More about Percutaneous Coronary Angioplasty in Patients with Cancer: Clinical Challenges and Management Strategies.

Five-Year Outcomes After Coronary Computed Tomography Angiography (From 110,599 Patients in a Danish Nationwide Register-Based Follow-Up Study). (2022)
Journal Article
Mamas. (2022). Five-Year Outcomes After Coronary Computed Tomography Angiography (From 110,599 Patients in a Danish Nationwide Register-Based Follow-Up Study). American Journal of Cardiology, 1 - 7. https://doi.org/10.1016/j.amjcard.2022.04.035

The long-term cardiovascular risk for patients examined with coronary computed tomography angiography (CCTA) to rule out coronary heart disease compared with population controls remains unexplored. A nationwide register-based study including first-ti... Read More about Five-Year Outcomes After Coronary Computed Tomography Angiography (From 110,599 Patients in a Danish Nationwide Register-Based Follow-Up Study)..

Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis (2022)
Journal Article
Peel, J. K., Miranda, R. N., Naimark, D., Woodward, G., Mamas, M. A., Madan, M., & Wijeysundera, H. C. (2022). Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis. Journal of the American Heart Association, 11(8), Article ARTN e025085. https://doi.org/10.1161/jaha.121.025085

Background Transcatheter aortic valve implantation (TAVI) is a minimally invasive therapy for patients with severe aortic stenosis, which has become standard of care. The objective of this study was to determine the maximum cost-effective investment... Read More about Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis.