AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. (2021)
Journal Article
Morelle, J., Marechal, C., Yu, Z., Debaix, H., Corre, T., Lambie, M., …Devuyst, O. (2021). AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. New England Journal of Medicine, 385, 1570 - 1580. https://doi.org/10.1056/NEJMoa2034279

BACKGROUND: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribut... Read More about AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis..

Renal staffs' understanding of patients' experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia. (2021)
Journal Article
Jones, J. E., Damery, S. L., Allen, K., Johnson, D. W., Lambie, M., Holvoet, E., & Davies, S. J. (2021). Renal staffs' understanding of patients' experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia. PloS one, 15(7), Article e0254931. https://doi.org/10.1371/journal.pone.0254931

INTRODUCTION: Many studies have explored patients' experiences of dialysis and other treatments for kidney failure. This is the first qualitative multi-site international study of how staff perceive the process of a patient's transition from peritone... Read More about Renal staffs' understanding of patients' experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia..

A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis. (2021)
Journal Article
Davies, & Lambie. (2021). A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis. Kidney International, 1101-1111. https://doi.org/10.1016/j.kint.2021.05.037

Movement of solutes across the peritoneum allows for the use of peritoneal dialysis to treat kidney failure. However, there is a large inter-individual variability in the peritoneal solute transfer rate (PSTR). Here, we tested the hypothesis that com... Read More about A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis..

Single-dwell treatment with a low-sodium solution in hypertensive peritoneal dialysis patients. (2020)
Journal Article
Davies. (2020). Single-dwell treatment with a low-sodium solution in hypertensive peritoneal dialysis patients. https://doi.org/10.1177/0896860820924136

BACKGROUND: Patients on peritoneal dialysis (PD) may suffer from sodium (Na) and fluid overload, hypertension and increased cardiovascular risk. Low-Na dialysis solution, by increasing the diffusive removal of Na, might improve blood pressure (BP) ma... Read More about Single-dwell treatment with a low-sodium solution in hypertensive peritoneal dialysis patients..

International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis (2020)
Journal Article
Brown, E. A., Blake, P. G., Boudville, N., Davies, S., de Arteaga, J., Dong, J., …Warady, B. (2020). International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 40(3), 244- 253. https://doi.org/10.1177/0896860819895364

The International Society for Peritoneal Dialysis last published a guideline on prescribing peritoneal dialysis (PD) in 2006. This focused on clearance of toxins and used a measure of waste product removal by dialysis using urea as an example. This g... Read More about International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis.

Accuracy of the estimation of V and the implications this has when applying Kt/Vurea for measuring dialysis dose in peritoneal dialysis (2020)
Journal Article
Davies, S., & Finkelstein, F. O. (2020). Accuracy of the estimation of V and the implications this has when applying Kt/Vurea for measuring dialysis dose in peritoneal dialysis. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 40(3), 261 - 269. https://doi.org/10.1177/0896860819893817

BACKGROUND: Current guidelines for the prescription of peritoneal dialysis dose rely on a single cut-off 'minimal' value of Kt/V. To apply this in the clinic, this requires an accurate estimation of V, the volume of urea distribution that equates to... Read More about Accuracy of the estimation of V and the implications this has when applying Kt/Vurea for measuring dialysis dose in peritoneal dialysis.

Biocompatible solutions and long-term changes in peritoneal solute transport (vol 13, pg 1526, 2018) (2019)
Journal Article
Davies, & Lambie. (2019). Biocompatible solutions and long-term changes in peritoneal solute transport (vol 13, pg 1526, 2018). Clinical Journal of the American Society of Nephrology, 909 - 909. https://doi.org/10.2215/CJN.02830319

Background and objectives: The inflammation-driven increase in peritoneal solute transport rate that occurs during long-term peritoneal dialysis is associated with higher mortality, hospitalization, and encapsulating peritoneal sclerosis. Because bio... Read More about Biocompatible solutions and long-term changes in peritoneal solute transport (vol 13, pg 1526, 2018).