Traditional processing techniques impacted the bioactivities of selected local consumed foods (2023)
Journal Article
Li. (2023). Traditional processing techniques impacted the bioactivities of selected local consumed foods. https://doi.org/10.1016/j.sciaf.2023.e01558

Epidemiological and clinical studies have evidenced the crucial role of vegetables and mushrooms for our health. Vegetables and mushrooms are usually cooked before consumption which induces many physicochemical changes in foods. A change in the phyto... Read More about Traditional processing techniques impacted the bioactivities of selected local consumed foods.

Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells (2022)
Journal Article
Kitchen, Li, & Reynisson. (2022). Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells. https://doi.org/10.1016/j.prmcm.2022.100074

Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associat... Read More about Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells.

Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats (2022)
Journal Article
Okokon, J. E., Davies, K., John, L., Iwara, K., Li, W.-W., & Thomas, P. S. (2022). Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats. Phytomedicine Plus, https://doi.org/10.1016/j.phyplu.2021.100182

Background
Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a grass used ethnomedically by herbalists in Nigeria for the treatment of diabetes was evaluated for antidiabetic, hypolipidemic and pancreas protective potentials in rats.

Methods
So... Read More about Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats.

Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells (2021)
Journal Article
Fadayomi, I. E., Johnson-Ajinwo, O. R., Pires, E., McCullagh, J., Claridge, T. D., Forsyth, N. R., & Li, W. (2021). Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells. Molecules, 26(19), 5933 - 5933. https://doi.org/10.3390/molecules26195933

Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics. Drug discovery from edible and medicinal plants represents a promising approach towards finding safer anticancer therapeutics. Justicia insularis T. Anderson... Read More about Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells.

In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of novel semisynthetic analogues. (2020)
Journal Article
Ijeoma Uche, F., Guo, X., Okokon, J., Ullah, I., Horrocks, P., Boateng, J., …Li, W. (2020). In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of novel semisynthetic analogues. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/AAC.01995-20

Bisbenzylisoquinoline (BBIQ) alkaloids are a diverse group of natural products that demonstrate a range of biological activities. In this study, the in vitro antiplasmodial activity of three BBIQ alkaloids (cycleanine (1), isochondodendrine (2) and 2... Read More about In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of novel semisynthetic analogues..

Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress (2020)
Journal Article
Rummun, N., Pires, E., McCullagh, J., Claridge, T. W., Bahorun, T., Li, W., & Neergheen, V. S. (2021). Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress. South African Journal of Botany, 137, 149 - 158. https://doi.org/10.1016/j.sajb.2020.10.014

Whilst the pharmacological potential of Syzygium species is well reported in the literature, data on the Mauritian endemic Syzygium species is limited. Thus, the in vitro antioxidant and anti-proliferative properties of three endangered Syzygium spec... Read More about Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress.