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A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2025)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Stokes-Fisher, J., Peffers, M., El Masri, W., …Wright, K. (2025). A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome. Journal of Neurotrauma, 42(3-4), https://doi.org/10.1101/2022.07.12.499696

Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues with the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult to predict, particularly... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

Training healthcare professionals to be ready for practice in an era of social distancing: A realist evaluation (2023)
Journal Article
Lefroy, J., Bialan, J., Moult, A., Hay, F., Stapleton, C., Thompson, J., …Cope, N. (2023). Training healthcare professionals to be ready for practice in an era of social distancing: A realist evaluation. Advances in Health Sciences Education, https://doi.org/10.1007/s10459-023-10297-w

Background
Programme changes due to the COVID-19 pandemic have impacted variably on preparation for practice of healthcare professional students. Explanations for such variability need exploration. The aim of our study was to understand what clinica... Read More about Training healthcare professionals to be ready for practice in an era of social distancing: A realist evaluation.

Subtalar joint moments of children with cerebral palsy (2023)
Journal Article
Meilak, E., Modenese, L., Andrew, R., Julie, S., Edward, C., & Stewart, C. (in press). Subtalar joint moments of children with cerebral palsy. Gait & Posture, 106, S121. https://doi.org/10.1016/j.gaitpost.2023.07.151

Introduction
Children with cerebral palsy (CP) often develop foot deformities [1], such as equinovarus, planovalgus non-midfoot break (PNMFB) and midfoot break (MFB) [2]. The aetiology of the development and progr... Read More about Subtalar joint moments of children with cerebral palsy.

The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity (2023)
Thesis
Tsang, K. S. (2023). The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity. (Thesis). Keele University

Spinal deformity involves a wide spectrum of disease, including congenital, developmental, degenerative and traumatic; affecting infant, adolescence and the elderly. Of these, Sheuermann’s kyphosis is a form of developmental long spinal deformity, ch... Read More about The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity.

Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo (2023)
Journal Article
Nafchi, N., Chilcott, E., Owen, S., Fuller, H., Bowerman, M., & Yáñez-Muñoz, R. (2023). Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo. Gene Therapy, 30, 812–825. https://doi.org/10.1038/s41434-023-00406-0

Spinal muscular atrophy (SMA) is a neuromuscular disease particularly characterised by degeneration of ventral motor neurons. Survival motor neuron (SMN) 1 gene mutations cause SMA, and gene addition strategies to replace the faulty SMN1 copy are a t... Read More about Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo.

Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. (2023)
Journal Article
Hulme, C., & Wright, K. (2023). Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. American Journal of Sports Medicine, 51(6), 1422-1433. https://doi.org/10.1177/03635465231156616

BACKGROUND: Stratification is required to ensure that only patients likely to benefit receive autologous chondrocyte implantation (ACI). It would be advantageous to identify biomarkers to predict ACI outcome that are measurable in blood, avoiding the... Read More about Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening..

Traditional processing techniques impacted the bioactivities of selected local consumed foods (2023)
Journal Article
Li. (2023). Traditional processing techniques impacted the bioactivities of selected local consumed foods. https://doi.org/10.1016/j.sciaf.2023.e01558

Epidemiological and clinical studies have evidenced the crucial role of vegetables and mushrooms for our health. Vegetables and mushrooms are usually cooked before consumption which induces many physicochemical changes in foods. A change in the phyto... Read More about Traditional processing techniques impacted the bioactivities of selected local consumed foods.

Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells. (2023)
Journal Article
Solheim, J., Brandsrud, M., Kong, B., Banyasz, A., Borondics, F., Micouin, G., …Kohler, A. (2023). Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells. Scientific reports, 13(1), Article 3165. https://doi.org/10.1038/s41598-023-30130-z

It is well known that infrared microscopy of micrometer sized samples suffers from strong scattering distortions, attributed to Mie scattering. The state-of-the-art preprocessing technique for modelling and removing Mie scattering features from infra... Read More about Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells..

Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. (2023)
Journal Article
Taylor, L., Wade, P. K., Johnson, J. E., Aldighieri, M., Morlando, S., Di Leva, G., …Coyle, B. (2023). Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. Cancers, 15(4), Article 1086. https://doi.org/10.3390/cancers15041086

Therapy resistance represents an unmet challenge in the treatment of medulloblastoma. Accordingly, the identification of targets that mark drug-resistant cell populations, or drive the proliferation of resistant cells, may improve treatment strategie... Read More about Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature..

World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention (2023)
Journal Article
Roffe. (2023). World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention. Postępy w Kardiologii Interwencyjnej, 19(1), 6-13. https://doi.org/10.5114/aic.2023.124742

Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most cou... Read More about World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention.

Enhanced antifouling properties of marine antimicrobial peptides by PEGylation. (2023)
Journal Article
Lou, T., Bai, X., He, X., Liu, W., Yang, Z., Yang, Y., & Yuan, C. (2023). Enhanced antifouling properties of marine antimicrobial peptides by PEGylation. Frontiers in Bioengineering and Biotechnology, 1124389 - ?. https://doi.org/10.3389/fbioe.2023.1124389

Covalent immobilisation of antimicrobial peptides (AMPs) on underwater surfaces to combat marine biofouling is of great interest as it is an efficient, broad-spectrum and environmentally friendly strategy. Similar to post-translational modifications... Read More about Enhanced antifouling properties of marine antimicrobial peptides by PEGylation..

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro (2023)
Journal Article
Dale, T. P., Santer, M. D., Haris, M., Zuo, W., & Forsyth, N. R. (2023). Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro. Experimental Lung Research, 49(1), 12-26. https://doi.org/10.1080/01902148.2022.2158404

PURPOSE: Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor pulmonale. However, minimal attention has been given to the effects of hypoxia at the ce... Read More about Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro.

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. (2022)
Journal Article
Rotherham, M., Moradi, Y., Nahar, T., Mosses, D., Telling, N., & El Haj, A. (2022). Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. Frontiers in Medical Technology, 4, Article 981421. https://doi.org/10.3389/fmedt.2022.981421

TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter... Read More about Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells..

Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial (2022)
Journal Article
Roffe. (2022). Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine, https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial.

Remote magnetic actuation of cell signalling for tissue engineering (2022)
Journal Article
Rotherham, M., Nahar, T., Broomhall, T., Telling, N., & El Haj, A. (2022). Remote magnetic actuation of cell signalling for tissue engineering. Current Opinion in Biomedical Engineering, 24, Article 100410. https://doi.org/10.1016/j.cobme.2022.100410

Magnetic nanoparticles (MNP) are extremely versatile tools in bioengineering and medicine with diverse uses ranging from magnetic resonance contrast agents to drug delivery vehicles. Recently, MNP have been adapted to target and regulate cell signall... Read More about Remote magnetic actuation of cell signalling for tissue engineering.

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. (2022)
Journal Article
Dhillon, K., Aizel, K., Broomhall, T., Secret, E., Goodman, T., Rotherham, M., …Gates, M. (2022). Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. Journal of the Royal Society. Interface, 19(196), https://doi.org/10.1098/rsif.2022.0576

A challenge in current stem cell therapies for Parkinson's disease (PD) is controlling neuronal outgrowth from the substantia nigra towards the targeted area where connectivity is required in the striatum. Here we present progress towards controlling... Read More about Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients..

Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent (2022)
Journal Article
Shephard, M., Merkhan, M., & Forsyth, N. (2022). Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms232113596

The Human Mesenchymal Stem Cell (hMSC) secretome has pleiotropic effects underpinning its therapeutic potential. hMSC serum-free conditioned media (SFCM) contains a variety of cytokines, with previous studies linking a changed secretome composition t... Read More about Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent.

Phenotypic characterization of regional human meniscus progenitor cells. (2022)
Journal Article
(2022). Phenotypic characterization of regional human meniscus progenitor cells. Frontiers in Bioengineering and Biotechnology, 1003966 - ?. https://doi.org/10.3389/fbioe.2022.1003966

Stimulating meniscus regeneration using meniscal progenitor cells has been suggested as a promising new strategy. However, there is a lack of studies which decisively identify and characterize progenitor cell populations in human meniscus tissues. In... Read More about Phenotypic characterization of regional human meniscus progenitor cells..