How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress? (2024)
Thesis
Awan, H. (2024). How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress?. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/849807

People with physical-mental comorbidity have a poorer quality of life, worse clinical outcomes and increased mortality than those with physical conditions alone. Those from some ethnic groups may be less likely to recognise and seek help for symptoms... Read More about How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress?.

The role of physiotherapy in polymyalgia rheumatica in the United Kingdom: a mixed method study (2023)
Thesis
O'Brien, A. V. (2023). The role of physiotherapy in polymyalgia rheumatica in the United Kingdom: a mixed method study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674475

Background: Polymyalgia Rheumatica (PMR) is the commonest rheumatic condition affecting older people, typically treated with glucocorticoids. However, the treatment side-effects including fatigue, anxiety and other alterations in mood, are frequent a... Read More about The role of physiotherapy in polymyalgia rheumatica in the United Kingdom: a mixed method study.

Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research (2023)
Thesis
Ranjbar, J. A. (2023). Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674551

Intravital microscopy in mice is widely used to study in vivo thrombus formation, however, the relevance of these studies to human physiology is unclear. In this thesis, a 3D tissue-engineered human arterial construct (TEAC) was developed that replic... Read More about Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research.

Primary care prescribing of orlistat medication for weight management in adults with type 2 diabetes: an epidemiological study (2023)
Thesis
Ghosal, S. (2023). Primary care prescribing of orlistat medication for weight management in adults with type 2 diabetes: an epidemiological study. (Thesis). Keele University

Introduction
The incidence of type 2 Diabetes mellitus (T2DM) is increasing and is a major public health burden. Obesity is one of the main modifiable risk factors for T2DM. However no UK studies have assessed the relationship of orlistat, a medica... Read More about Primary care prescribing of orlistat medication for weight management in adults with type 2 diabetes: an epidemiological study.

Association of frailty status with the causes, characteristics and outcomes of patients with cardiovascular disease using electronic health record data (2023)
Thesis
Sokhal, B. S. (2023). Association of frailty status with the causes, characteristics and outcomes of patients with cardiovascular disease using electronic health record data. (Thesis). Keele University

Introduction
Cardiovascular disease (CVD) is the commonest cause of morbidity and mortality worldwide. Frailty is a clinical syndrome of physiological decline, resulting in adverse health outcomes. While the bidirectional relationship between CVD a... Read More about Association of frailty status with the causes, characteristics and outcomes of patients with cardiovascular disease using electronic health record data.

The management of varices in acute on chronic liver failure: a systematic review of guidelines and investigation of local practice (2023)
Thesis
Kesavan, S. (2023). The management of varices in acute on chronic liver failure: a systematic review of guidelines and investigation of local practice. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/515604

Varices are a complication of chronic liver disease and are associated with a high mortality if they haemorrhage. Patients need to be managed using the best available evidence to improve their outcomes. This thesis is formed of two parts: a systemati... Read More about The management of varices in acute on chronic liver failure: a systematic review of guidelines and investigation of local practice.

Statistical methods for prognostic factor and risk prediction research (2023)
Thesis
Whittle, R. L. (2023). Statistical methods for prognostic factor and risk prediction research. (Thesis). Keele University

Prognosis research is an important part of medical research as it seeks to understand, predict, and improve future outcomes in people with a given disease or health condition. This thesis focuses on the application and development of statistical meth... Read More about Statistical methods for prognostic factor and risk prediction research.

The role of Endothelial Progenitor Cells in the pleiotropic effects of Atorvastatin (2023)
Thesis
Sandhu, K. S. (2023). The role of Endothelial Progenitor Cells in the pleiotropic effects of Atorvastatin. (Thesis). Keele University

The following thesis began by discussing current controversies surrounding EPC identification then studied the effect of atorvastatin on EPC numbers in bench and bed side studies.
Atorvastatin was hypothesised to increase chemokine CXCL-12 its recep... Read More about The role of Endothelial Progenitor Cells in the pleiotropic effects of Atorvastatin.

Neural immune cell responses to clinically relevant ligands of the niacin receptor (Gpr109a): niacin and monomethyl fumarate (2023)
Thesis
Brown-Lyons, A. L. (2023). Neural immune cell responses to clinically relevant ligands of the niacin receptor (Gpr109a): niacin and monomethyl fumarate. (Thesis). Keele University

Background: Inflammation is a major driver, and perhaps cause, of neurodegeneration, suggesting neuroimmunomodulation as a therapeutic strategy. Microglia, the primary mediators of neuroinflammation, switch between three activation states [surveillan... Read More about Neural immune cell responses to clinically relevant ligands of the niacin receptor (Gpr109a): niacin and monomethyl fumarate.

The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity (2023)
Thesis
Tsang, K. S. (2023). The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity. (Thesis). Keele University

Spinal deformity involves a wide spectrum of disease, including congenital, developmental, degenerative and traumatic; affecting infant, adolescence and the elderly. Of these, Sheuermann’s kyphosis is a form of developmental long spinal deformity, ch... Read More about The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity.

Impact of different practice patterns on solute transport in peritoneal dialysis (2023)
Thesis
Brenna, I. (2023). Impact of different practice patterns on solute transport in peritoneal dialysis. (Thesis). Keele University

Long term peritoneal dialysis (PD) is associated with increased peritoneal solute transport rate (PSTR) and loss of ultrafiltration capacity [1,2], both reflecting acquired structural alterations of the peritoneal membrane. Peritoneal functional chan... Read More about Impact of different practice patterns on solute transport in peritoneal dialysis.

The association between gout and psychological co-morbidity: results from a prospective cohort study (2023)
Thesis
Higgs, J. J. R. (2023). The association between gout and psychological co-morbidity: results from a prospective cohort study. (Thesis). Keele University

Gout is associated with an increased risk of both physical-health co-morbidities and a reduction in physical health-related quality of life. However, the association between gout and psychological comorbidity (depression and anxiety) has received lit... Read More about The association between gout and psychological co-morbidity: results from a prospective cohort study.

Conceptualising and measuring adherence to exercise for musculoskeletal pain: The Adherence To Exercise for Musculoskeletal Pain Tool (ATEMPT) (2022)
Thesis
Bailey, D. L. (2022). Conceptualising and measuring adherence to exercise for musculoskeletal pain: The Adherence To Exercise for Musculoskeletal Pain Tool (ATEMPT). (Thesis). Keele University

Aim: To develop and test a measurement tool for adherence to exercise for musculoskeletal (MSK) pain.

Purpose: A valid and reliable measure of adherence to exercise will improve the interpretation of whether outcomes observed in studies of exercis... Read More about Conceptualising and measuring adherence to exercise for musculoskeletal pain: The Adherence To Exercise for Musculoskeletal Pain Tool (ATEMPT).

Developing tools for inter-site transport of brain tissue models in tissue engineering research (2022)
Thesis
Kabiri, B. (2022). Developing tools for inter-site transport of brain tissue models in tissue engineering research. (Thesis). Keele University

Penetrating traumatic brain injury (pTBI) remains one of the leading causes of death in the younger population in the UK, as no clinical regenerative therapies are available. Experimental therapies currently being screened for efficacy are wide rangi... Read More about Developing tools for inter-site transport of brain tissue models in tissue engineering research.

Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records (2022)
Thesis
Dyer, B. P. (2022). Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records. (Thesis). Keele University

Introduction
Frozen shoulder, a condition that can cause prolonged pain and disability, has previously been found to be common amongst people with diabetes. This thesis aimed to improve the understanding of the nature of the relationship between dia... Read More about Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records.

Practice Readiness: An English exploratory study describing newly qualified graduate nurses’ perceptions of practice readiness and professional identity (2022)
Thesis
Sargeant, K. E. (2022). Practice Readiness: An English exploratory study describing newly qualified graduate nurses’ perceptions of practice readiness and professional identity. (Thesis). Keele University

Background: Greater understanding of NQNs’ perceptions of their pre-registration and transition experiences, and influences on their perceptions can inform pre-registration curricula and preceptorship programmes to support a positive transition to qu... Read More about Practice Readiness: An English exploratory study describing newly qualified graduate nurses’ perceptions of practice readiness and professional identity.

Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica (2022)
Thesis
Twohig, H. J. (2022). Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica. (Thesis). Keele University

Background
Polymyalgia rheumatica (PMR) causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient’s perspective is vital to highquality research and patient-centred care, yet there are no validated... Read More about Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica.

Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis (2021)
Thesis
Echrish, J. H. J. (2021). Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis. (Thesis). Keele University

Coronary heart disease is the primary global cause of morbidity and mortality, accounting for about 33% of global deaths in 2013. Atherosclerosis is the principal cause of coronary heart disease and is caused by inflammation of the arterial wall. Thi... Read More about Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis.

Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study (2021)
Thesis
Mughal, F. H. (2021). Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study. (Thesis). Keele University

Self-harm in young people is a national priority. General practitioners see young people who self-harm the most often in the National Health Service (NHS), and episodes of self-harm in young people presenting to general practice are rising. General p... Read More about Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study.

Evaluation of surgical outcomes using administrative hospital data (2021)
Thesis
El-Dhuwaib, Y. (2021). Evaluation of surgical outcomes using administrative hospital data. (Thesis). Keele University

Hospital Episode Statistics (HES) is the main hospital administrative dataset in England. Since the early 1990s HES has been used for research. The aim of the thesis is to evaluate the use of HES data to measure surgical outcomes.

Objectives:
1.... Read More about Evaluation of surgical outcomes using administrative hospital data.