Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach (2018)
Thesis
AL-Jumaily, R. M. K. (2018). Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412295

Oxygen is an essential factor for life in many organisms. Oxygen concentrations vary widely across different human tissues, but in general, are much lower than the 21% oxygen in atmospheric air. In spite of this, most research continues to be based o... Read More about Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach.

Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs (2018)
Journal Article
Yeates, P., Cope, N., Hawarden, A., Bradshaw, H., McCray, G., & Homer, M. (2019). Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs. Medical Education, 53(3), 250-263. https://doi.org/10.1111/medu.13783

Background:
Whilst averaging across multiple examiners judgements reduces unwanted overall score variability in Objective Structured Clinical Examinations (OSCE), designs involving several parallel circuits of the OSCE require that different examin... Read More about Developing a video-based method to compare and adjust examiner effects in fully nested OSCEs.

Comparatively salient: examining the influence of preceding performances on assessors' focus and interpretations in written assessment comments. (2018)
Journal Article
Yeates. (2018). Comparatively salient: examining the influence of preceding performances on assessors' focus and interpretations in written assessment comments. Advances in Health Sciences Education, 937-959. https://doi.org/10.1007/s10459-018-9841-2

Recent literature places more emphasis on assessment comments rather than relying solely on scores. Both are variable, however, emanating from assessment judgements. One established source of variability is "contrast effects": scores are shifted away... Read More about Comparatively salient: examining the influence of preceding performances on assessors' focus and interpretations in written assessment comments..

Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis (2018)
Journal Article
(2018). Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology, 825 - 836. https://doi.org/10.1016/S2468-1253%2818%2930421-7

Background In patients with rectal cancer who achieve clinical complete response after neoadjuvant chemoradiotherapy, watch and wait is a novel management strategy with potential to avoid major surgery. Study-level meta-analyses have reported wide va... Read More about Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis.

The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach (2018)
Journal Article
Haider, N., Laaksonen, S., Kjær, L. J., Oksanen, A., & Bødker, R. (in press). The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach. Parasites and Vectors, 11, Article 565. https://doi.org/10.1186/s13071-018-3159-z

Background
In northern Finland (Lapland), reindeer are reared as semi-domesticated animals. The region has a short summer season of 2–3 months, yet reindeer are infected with the mosquito-borne filarioid parasite Setaria tundra. The infection causes... Read More about The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach.

Promoting academic general practice: perspectives from early career clinical academics (2018)
Journal Article
Mulla, E., & Mughal, F. (2018). Promoting academic general practice: perspectives from early career clinical academics. Education for Primary Care,

Letter to the Editor.

One-Year Outcomes after PCI Strategies in Cardiogenic Shock. (2018)
Journal Article
Mamas. (2018). One-Year Outcomes after PCI Strategies in Cardiogenic Shock. New England Journal of Medicine, 1699 - 1710. https://doi.org/10.1056/NEJMoa1808788

BACKGROUND: Among patients with acute myocardial infarction, cardiogenic shock, and multivessel coronary artery disease, the risk of a composite of death from any cause or severe renal failure leading to renal-replacement therapy at 30 days was found... Read More about One-Year Outcomes after PCI Strategies in Cardiogenic Shock..

Exploring the Relationship between Examiners’ Memories for performances, domain separation and score variability. (2018)
Journal Article
Yeates, & McCray. (2018). Exploring the Relationship between Examiners’ Memories for performances, domain separation and score variability. Medical Teacher, 1159-1165. https://doi.org/10.1080/0142159X.2018.1463088

Background: OSCE examiners' scores are variable and may discriminate domains of performance poorly. Examiners must hold their observations of OSCE performances in "episodic memory" until performances end. We investigated whether examiners vary in the... Read More about Exploring the Relationship between Examiners’ Memories for performances, domain separation and score variability..

Investigation of cellular and scaffold strategies for engineering articular cartilage (2018)
Thesis
Abu Owida, H. (2018). Investigation of cellular and scaffold strategies for engineering articular cartilage. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412022

Articular cartilage is a thin hydrated tissue, which covers articulating surfaces. In the native articular cartilage tissue, the extracellular matrix (ECM) is a fibrillar mesh of interacting proteoglycans, collagens, and other non-collagenous protein... Read More about Investigation of cellular and scaffold strategies for engineering articular cartilage.

Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines (2018)
Thesis
Al-Khazraji, S. K. A. (2018). Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412024

Background: Serine/Threonine protein phosphatase 4 (PP4) plays a crucial role in cell signalling, proliferation and apoptosis, and its catalytic subunit has been reported as an important regulator in many types of cancer, including breast and lung ca... Read More about Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines.

Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes (2018)
Journal Article
Riley, R. D., Snell, K. I. E., Ensor, J., Burke, D. L., Harrell, F. E., Moons, K. G. M., & Collins, G. S. (2019). Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes. Statistics in Medicine, 38(7), 1276-1296. https://doi.org/10.1002/sim.7992

When designing a study to develop a new prediction model with binary or time-to-event outcomes, researchers should ensure their sample size is adequate in terms of the number of participants (n) and outcome events (E) relative to the number of predic... Read More about Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes.

Vitamin B3 and Neurodevelopment in Parkinson's Disease (2018)
Presentation / Conference
(2018, October). Vitamin B3 and Neurodevelopment in Parkinson's Disease. Presented at 2018 International Congress, Hong Kong

Vitamin B3 and Neurodevelopment in Parkinson’s Disease
A. Williams, S. Griffin, R. Fricker (Birmingham, United Kingdom)

Meeting: 2018 International Congress

ABSTRACT NUMBER: 592

Keywords: Cell replacement therapy, Dopaminergic neurons

Se... Read More about Vitamin B3 and Neurodevelopment in Parkinson's Disease.

Where backyard poultry raisers seek care for sick poultry: implications for avian influenza prevention in Bangladesh (2018)
Journal Article
Rimi, N. A., Sultana, R., Ishtiak-Ahmed, K., Haider, N., Azziz-Baumgartner, E., Nahar, N., & Luby, S. P. (in press). Where backyard poultry raisers seek care for sick poultry: implications for avian influenza prevention in Bangladesh. BMC Public Health, 18, 1-9. https://doi.org/10.1186/s12889-018-5819-5

Background
In Bangladesh, backyard poultry raisers lack awareness of avian influenza and infrequently follow government recommendations for its prevention. Identifying where poultry raisers seek care for their ill poultry might help the government b... Read More about Where backyard poultry raisers seek care for sick poultry: implications for avian influenza prevention in Bangladesh.

Digital drug screening to detect falsified, expired andrecalled medicines (2018)
Thesis
Naughton, B. D. (2018). Digital drug screening to detect falsified, expired andrecalled medicines. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411443

Falsified medicines are a global health and pharmaceutical sector issue which affect supply chains in low, middle and high-income countries. There are many methods to identify substandard and falsified medicines. However, the European Union has intro... Read More about Digital drug screening to detect falsified, expired andrecalled medicines.

Risk factors for the onset of musculoskeletal pain in children and adolescents (2018)
Thesis
Andreucci, A. (2018). Risk factors for the onset of musculoskeletal pain in children and adolescents. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411391

Background

Musculoskeletal pain is a major burden on society. Research in adults has identified risk factors associated with musculoskeletal pain onset, however at present evidence for risk factors in children and adolescents is limited.

Aims... Read More about Risk factors for the onset of musculoskeletal pain in children and adolescents.

The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management (2018)
Thesis
Lindsay, C. (2018). The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411458

Introduction
Patients surviving a severe stroke are at risk of developing contractures. Evidence suggests that spasticity may be a cause of contractures, particularly in patients who have not recovered functional movement. The relationship and the t... Read More about The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management.

Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis (2018)
Thesis
Musa, F. (2018). Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411162

In this project, we have designed, constructed, and validated a human tissue-engineered blood vessel construct (TEBV) to assess whether it could be used as a new model system in which to study thrombus formation under physiologically relevant conditi... Read More about Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis.

Silicon in health: A beneficial element in reducing the body burden of aluminium (2018)
Thesis
Jones, K. L. (2018). Silicon in health: A beneficial element in reducing the body burden of aluminium. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411347

The essentiality of silicon and the toxicity of aluminium within humans are both topics of much debate; the current conception is that silicon is essential in ameliorating aluminium toxicity, however, the evidence for this remains inconclusive.

T... Read More about Silicon in health: A beneficial element in reducing the body burden of aluminium.

Validating models of injury risk prediction in football players (2018)
Thesis
Philp, F. D. (2018). Validating models of injury risk prediction in football players. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411140

Association football (soccer) is a popular sport and there is a high risk of injury for participants. Within the context of professional clubs, the risk of injury is also associated with the risk of financial costs. Therefore, injury reduction proces... Read More about Validating models of injury risk prediction in football players.

Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery (2018)
Thesis
Narayanasamy, K. K. (2018). Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411161

With the advent of powerful gene editing tools such as CRISPR/Cas9, advances in gene therapy have gained a second wind. Despite this, disease therapy still has not progressed beyond clinical trials due to limitations in current delivery methods. The... Read More about Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery.