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Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis. (2020)
Journal Article
Mamas. (2020). Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis. European Journal of Epidemiology, https://doi.org/10.1007/s10654-020-00710-8

The role of dietary calcium in cardiovascular disease prevention is unclear. We aimed to determine the association between calcium intake and incident cardiovascular disease and mortality. Data were extracted from the European Prospective Investigati... Read More about Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis..

The association between osteoarthritis and invasive management strategies and clinical outcomes following acute myocardial infarction in electronic health record data (2020)
Thesis
Parmar, S. S. (2020). The association between osteoarthritis and invasive management strategies and clinical outcomes following acute myocardial infarction in electronic health record data. (Thesis). Keele University

Background
The association between osteoarthritis (OA) and acute myocardial infarction (AMI) is unclear, as are the outcomes of people with OA diagnosed with AMI. This study aimed to describe the annual prevalence of OA among AMI patients and descri... Read More about The association between osteoarthritis and invasive management strategies and clinical outcomes following acute myocardial infarction in electronic health record data.

The role of the microbiome in rheumatoid arthritis (2020)
Thesis
Hammad, D. B. M. (2020). The role of the microbiome in rheumatoid arthritis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418967

The human microbiome plays a vital role in both health and disease. The evolution of molecular techniques to characterise entire microbiome communities has renewed interest in the involvement of microorganisms in the pathogenesis of Rheumatoid arthri... Read More about The role of the microbiome in rheumatoid arthritis.

Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons. (2020)
Journal Article
Kuiper. (2020). Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons. https://doi.org/10.1142/S2424835520500484

Background: Pulvertaft Weave (PTW) is an established method of tenorrhapy in tendon transfers. Previous studies have suggested that a Side-to-Side (STS) tenorrhapy is easier to perform has the same advantages and has greater load to failure, ultimate... Read More about Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons..

Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. (2020)
Journal Article
Gómez-Gálvez, Y., & Gates, M. (2020). Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. Journal of Neuroscience Methods, 109065 - ?. https://doi.org/10.1016/j.jneumeth.2020.109065

BACKGROUND: Primary embryonic ventral mesencephalic (VM) cultures are a high throughput tool for understanding and manipulating dopamine neurons, to study the mechanisms that trigger their degeneration during Parkinson's disease (PD), and to test new... Read More about Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons..

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article
Mycroft-West, C. J., Su, D., Pagani  , I., Rudd  , T. R., Elli  , S., Gandhi  , N. S., …Skidmore   , M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thrombosis and Haemostasis, 120(12), 1700 - 1715. https://doi.org/10.1055/s-0040-1721319

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..

Place and causes of acute cardiovascular mortality during the COVID-19 pandemic. (2020)
Journal Article
Mamas. (2020). Place and causes of acute cardiovascular mortality during the COVID-19 pandemic. Heart, 113-119. https://doi.org/10.1101/2020.07.14.20153734

Objective. To describe the place and causes of acute cardiovascular death during the COVID-19 pandemic.
Methods. Retrospective cohort of adult (age =18 years) acute cardiovascular deaths (n=587,225) in England and Wales, 1st January 2014 to 30th Jun... Read More about Place and causes of acute cardiovascular mortality during the COVID-19 pandemic..

Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A. H., Aziz, A., Alansari, R., Ferry, N., Krstic-Demonacos, M., & Ragazzon, P. (2020). Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note. (2020)
Journal Article
(2020). Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note. Medicina, https://doi.org/10.3390/medicina56120715

Purpose: Nowadays, surgical treatment of acute avulsions of the Achilles tendon represents a hard challenge. There is often the possibility that the calcaneus remains completely uncovered from the tendon, making the reinsertion of its distal stub com... Read More about Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note..

Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review. (2020)
Journal Article
Twohig, H., Owen, C., Muller, S., Mallen, C., Mitchell, C., Hider, S., …Hill, C. (2021). Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review. Journal of Rheumatology, 48(6), 883-893. https://doi.org/10.3899/jrheum.200248

OBJECTIVE: To systematically identify the outcome measures and instruments used in clinical studies of polymyalgia rheumatica (PMR) and to evaluate evidence about their measurement properties. METHODS: Searches based on the MeSH term 'polymyalgia rhe... Read More about Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review..

Comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. (2020)
Journal Article
Mallen. (2020). Comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. Health Policy and Planning, 341-356. https://doi.org/10.1093/heapol/czaa152

Clinical records in primary healthcare settings in low- and middle-income countries (LMIC) are often lacking or of too poor quality to accurately assess what happens during the patient consultation. We examined the most common methods for assessing h... Read More about Comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care..

Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan (2020)
Journal Article
Siam, H., Samy, A., Mohamed, W., Khalid, F., Gumaa, S., Mboera, L., …Ahmed, A. (2020). Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan. PLoS Neglected Tropical Diseases, e0008918 - e0008918. https://doi.org/10.1371/journal.pntd.0008918

<jats:p>Dengue is a rapidly growing public health threat in Kassala state, eastern Sudan. The objective of this study was to determine the seroprevalence, entomological transmission indices, and socioeconomic risk factors associated with dengue in th... Read More about Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan.

Patients' Views on the Implementation Potential of a Stratified Treatment Approach for Low Back Pain in Germany: A Qualitative Study. (2020)
Journal Article
Karstens, S., Lang, S., & Saunders, B. (2020). Patients' Views on the Implementation Potential of a Stratified Treatment Approach for Low Back Pain in Germany: A Qualitative Study. Health Services Insights, 13, https://doi.org/10.1177/1178632920977894

Stratified care for low back pain (LBP) has been shown to be clinically- and cost-effective in the UK, but its transferability to the German healthcare system is unknown. This study explores LBP patients' perspectives regarding future implementation... Read More about Patients' Views on the Implementation Potential of a Stratified Treatment Approach for Low Back Pain in Germany: A Qualitative Study..

Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis (2020)
Journal Article
Bhuiyan, M., Stiboy, E., Hassan, M., Chan, M., Islam, M., Haider, N., …Homaira, N. (2021). Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis. Vaccine, 39(4), 667 - 677. https://doi.org/10.1016/j.vaccine.2020.11.078

Introduction
Emerging evidence suggests young children are at greater risk of COVID-19 infection than initially predicted. However, a comprehensive understanding of epidemiology of COVID-19 infection in young children under five years, the most at-r... Read More about Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis.

Understanding the management of heart failure with preserved ejection fraction: a qualitative multiperspective study. (2020)
Journal Article
Chew-Graham. (2020). Understanding the management of heart failure with preserved ejection fraction: a qualitative multiperspective study. British Journal of General Practice (BJGP), 880-889. https://doi.org/10.3399/bjgp20X713477

BACKGROUND: About half of all people with heart failure have heart failure with preserved ejection fraction (HFpEF), in which the heart is stiff. This type of heart failure is more common in older people with a history of hypertension, obesity, and d... Read More about Understanding the management of heart failure with preserved ejection fraction: a qualitative multiperspective study..

Trends in sex-based differences in outcomes following coronary artery bypass grafting in the United States between 2004 and 2015 (2020)
Journal Article
Mamas. (2020). Trends in sex-based differences in outcomes following coronary artery bypass grafting in the United States between 2004 and 2015. International Journal of Cardiology, 42-48. https://doi.org/10.1016/j.ijcard.2020.07.039

Background
The present study sought to examine the trends of sex-based differences in clinical outcomes after coronary artery bypass grafting (CABG), an area in which the current evidence remains limited.
Methods
All US adults hospitalized for fir... Read More about Trends in sex-based differences in outcomes following coronary artery bypass grafting in the United States between 2004 and 2015.

Radiation dose from digital breast tomosynthesis screening - A comparison with full field digital mammography. (2020)
Journal Article
(2020). Radiation dose from digital breast tomosynthesis screening - A comparison with full field digital mammography. Journal of Medical Imaging and Radiation Sciences, 599-603

OBJECTIVES: To compare Mean Glandular Dose (MGD) and effective dose from digital breast tomosynthesis (DBT) screening with that from full field digital mammography (FFDM) screening. METHOD: To simulate compressed breasts, two Perspex-polyethylene bre... Read More about Radiation dose from digital breast tomosynthesis screening - A comparison with full field digital mammography..