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Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis (2021)
Thesis
Echrish, J. H. J. (2021). Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis. (Thesis). Keele University

Coronary heart disease is the primary global cause of morbidity and mortality, accounting for about 33% of global deaths in 2013. Atherosclerosis is the principal cause of coronary heart disease and is caused by inflammation of the arterial wall. Thi... Read More about Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis.

Entomological survey for identification of Aedes larval breeding sites and their distribution in Chattogram, Bangladesh (2021)
Journal Article
haider. (2021). Entomological survey for identification of Aedes larval breeding sites and their distribution in Chattogram, Bangladesh. Beni-Suef University Journal of Basic and Applied Sciences, 1-11. https://doi.org/10.1186/S43088-021-00122-X

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Studying the characteristics of <jats:italic>Aedes</jats:italic> mosquito habitats is essential to control the mosquito population. The objective of this study wa... Read More about Entomological survey for identification of Aedes larval breeding sites and their distribution in Chattogram, Bangladesh.

Students’ Experiences of Peer Observed Teaching: A Qualitative Interview Study (2021)
Journal Article
Rees. (2021). Students’ Experiences of Peer Observed Teaching: A Qualitative Interview Study. Teaching and Learning in Medicine, https://doi.org/10.1080/10401334.2021.2006665

Purpose: To summarise and appraise evidence on the prognosis and long-term clinical and socio-economic outcomes following wrist fracture among adults aged 50 years and over.

Methods: Five databases (MEDLINE, EMBASE, AMED, CINAHL-P and PsycINFO) we... Read More about Students’ Experiences of Peer Observed Teaching: A Qualitative Interview Study.

New developments in osteoarthritis pharmacological therapies. (2021)
Journal Article
(2021). New developments in osteoarthritis pharmacological therapies. Rheumatology, vi1 - vi11. https://doi.org/10.1093/rheumatology/keab679

OA is an increasingly common, painful condition with complex aetiology and limited therapies. Approaches to expanding our therapeutic armamentarium have included repurposing existing therapies used for other rheumatological conditions, modifying exis... Read More about New developments in osteoarthritis pharmacological therapies..

Emotional distress, anxiety and depression in South Asians with long-term conditions: a qualitative systematic review (2021)
Journal Article
Awan, H., Mughal, F., Kingstone, T., Chew-Graham, C., & Corp, N. (2022). Emotional distress, anxiety and depression in South Asians with long-term conditions: a qualitative systematic review. British Journal of General Practice (BJGP), 72(716), https://doi.org/10.3399/BJGP.2021.0345

Background:
People with physical-mental comorbidity have a poorer quality of life, worse clinical outcomes and increased mortality compared to people with physical conditions alone.
South Asians (SAs) are the largest minority group in the UK and a... Read More about Emotional distress, anxiety and depression in South Asians with long-term conditions: a qualitative systematic review.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., …Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

<jats:p>Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine (2021)
Journal Article
Harper. (2022). Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine. Cell Calcium, 101, 102522 - 102522. https://doi.org/10.1016/j.ceca.2021.102522

Human platelets regulate agonist-evoked Ca2+ signalling through Ca2+ release from and sequestration into acidic organelles. Previous studies have pharmacologically characterised the presence of a Ca2+-H+ exchanger in these organelles. This exchanger... Read More about Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine.

Improving research quality: The view from the UK Reproducibility Network institutional leads for research improvement (2021)
Journal Article
Grange. (2021). Improving research quality: The view from the UK Reproducibility Network institutional leads for research improvement. BMC Research Notes, https://doi.org/10.1186/s13104-021-05883-3

The adoption and incentivisation of open and transparent research practices is critical in addressing issues around research reproducibility and research integrity. These practices will require training and funding. Individuals need to be incentivise... Read More about Improving research quality: The view from the UK Reproducibility Network institutional leads for research improvement.

Can we check serum lithium levels less often without compromising patient safety? (2021)
Journal Article
Heald, A. H., Holland, D., Stedman, M., Davies, M., Duff, C. J., Parfitt, C., …Fryer, A. A. (2021). Can we check serum lithium levels less often without compromising patient safety?. BJPsych Open, e18 - ?. https://doi.org/10.1192/bjo.2021.1027

BACKGROUND: Lithium is viewed as the first-line long-term treatment for prevention of relapse in people with bipolar disorder.

AIMS: This study examined factors associated with the likelihood of maintaining serum lithium levels within the recomme... Read More about Can we check serum lithium levels less often without compromising patient safety?.

Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital (2021)
Journal Article
Hanna, F. W. F., Hancock, S., George, C., Clark, A., Sim, J., Issa, B. G., …Fryer, A. A. (2022). Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital. Journal of the Endocrine Society, 6(1), https://doi.org/10.1210/jendso/bvab180

Context: Adrenal incidentalomas (AIs) are increasingly being identified during unrelated imaging. Unlike AI clinical management, data on referral patterns in routine practice are lacking. Objective: This work aimed to identify factors associated with... Read More about Adrenal Incidentaloma: Prevalence and Referral Patterns From Routine Practice in a Large UK University Teaching Hospital.

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (2021)
Journal Article
de Leon, J., Schoretsanitis, G., Smith, R. L., Molden, E., Solismaa, A., Seppälä, N., …Marder, S. R. (2021). An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry, 55(02), 73-86. https://doi.org/10.1055/a-1625-6388

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and... Read More about An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. (2021)
Journal Article
Corrà, F., Crudele, F., Baldassari, F., Bianchi, N., Galasso, M., Minotti, L., …Volinia, S. (2021). UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. Genes, 12(12), Article 1978. https://doi.org/10.3390/genes12121978

In the human genome, there are about 600 ultra-conserved regions (UCRs), long DNA sequences extremely conserved in vertebrates. We performed a large-scale study to quantify transcribed UCR (T-UCR) and miRNA levels in over 6000 cancer and normal tissu... Read More about UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines..

What challenges did junior doctors face while working during the COVID-19 pandemic? A qualitative study. (2021)
Journal Article
Chew-Graham. (2021). What challenges did junior doctors face while working during the COVID-19 pandemic? A qualitative study. BMJ Open, e056122 - ?. https://doi.org/10.1136/bmjopen-2021-056122

OBJECTIVES: This paper reports findings exploring junior doctors' experiences of working during the COVID-19 pandemic in the UK. DESIGN: Qualitative study using in-depth interviews with 15 junior doctors. Interviews were audio-recorded, transcribed,... Read More about What challenges did junior doctors face while working during the COVID-19 pandemic? A qualitative study..

Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study (2021)
Journal Article
Rashid, Mamas, & Nolan. (2021). Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study. European Journal of Preventive Cardiology, 1084-1092. https://doi.org/10.1093/eurjpc/zwab200

Background: The importance of standard modifiable cardiovascular risk factors (SMuRFs) in preventing non-ST segment myocardial infarction (NSTEMI) is established. However, NSTEMI may present in the absence of SMuRFs, and little is known about their o... Read More about Addressing disparities of care in non-ST-segment elevation myocardial infarction (NSTEMI) patients without standard modifiable risk factors: insights from a nationwide cohort study.

Determining influence, interaction and causality of Contrast and Sequence effects in OSCEs. (2021)
Journal Article
Yeates, P., Moult, A., Cope, N., McCray, G., Fuller, R., & McKinley, R. (2022). Determining influence, interaction and causality of Contrast and Sequence effects in OSCEs. Medical Education, 56(3), 292-302. https://doi.org/10.1111/medu.14713

INTRODUCTION: Differential rater function over time (DRIFT) and contrast effects (examiners' scores biased away from the standard of preceding performances) both challenge the fairness of scoring in Objective Structured Clinical Exams (OSCEs). This i... Read More about Determining influence, interaction and causality of Contrast and Sequence effects in OSCEs..

An evaluation of the use of investigations in a nurse-led rapid access chest pain clinic (2021)
Journal Article
Mallen. (2021). An evaluation of the use of investigations in a nurse-led rapid access chest pain clinic. British Journal of Cardiac Nursing, 1 - 14. https://doi.org/10.12968/bjca.2021.0084

<jats:sec><jats:title>Background/Aims</jats:title><jats:p> Chest pain is a common symptom, but its presentation and cause varies widely, making diagnosis a challenge. This study describes the authors' experience of a nurse-led rapid access chest pain... Read More about An evaluation of the use of investigations in a nurse-led rapid access chest pain clinic.

Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease. (2021)
Journal Article
Dziedzic. (2021). Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease. Physiotherapy Theory and Practice, 1 - 8. https://doi.org/10.1080/09593985.2021.2010847

OBJECTIVES: To explore two linked strategies to highlight the best current available evidence for hydrotherapy and to explore the barriers and enablers to mobilizing this evidence into practice. METHOD: Phase 1: The best published evidence for hydrot... Read More about Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease..

Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States. (2021)
Journal Article
Rashid, & Mamas. (2021). Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States. https://doi.org/10.1016/j.cjco.2021.06.012

Background: Female patients have been shown to experience worse clinical outcomes after acute myocardial infarction (AMI) compared with male patients. However, it is unclear what trend these differences followed over time. Methods: Data from patients... Read More about Trends of Sex Differences in Clinical Outcomes After Myocardial Infarction in the United States..

Autobodies: Detectives, Disorders, and Getting out of the Neighborhood (2021)
Journal Article
Peacock. (2021). Autobodies: Detectives, Disorders, and Getting out of the Neighborhood. European Journal of American Studies, 1-22. https://doi.org/10.4000/ejas.17534

This article explores two detective stories featuring protagonists with neurological conditions. Lionel Essrog, the narrator of Jonathan Lethem’s Motherless Brooklyn (1999), suffers from Tourette’s Syndrome, and Mark Genevich, hero of Paul Tremblay’s... Read More about Autobodies: Detectives, Disorders, and Getting out of the Neighborhood.