Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes (2022)
Journal Article
Mamas. (2022). Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes. Diabetes Care, 909-918. https://doi.org/10.2337/dc21-1113

OBJECTIVE
To assess associations between current use of sodium–glucose cotransporter 2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP-1RAs), and their combination and risk for major adverse cardiac and cerebrovascular events (M... Read More about Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes.

Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529) - highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts (2022)
Journal Article
Haider, N. (2022). Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529) - highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts. International Journal of Infectious Diseases, 268 - 272. https://doi.org/10.1016/j.ijid.2021.11.040

Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA (2022)
Journal Article
Chen, Y., Ma, Z., Yu, D., Jiang, Z., Wang, B., & Yuan, L. (2022). Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA. Environmental Geochemistry and Health, 44, 4423–4436. https://doi.org/10.1007/s10653-022-01204-0

Severe outcome particularly death is the largest burden of COVID-19. Clinical observations showed preliminary data that deficiency in certain trace elements, essential for the normal activity of immune system, may be associated with worse COVID-19 ou... Read More about Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA.

Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. (2022)
Journal Article
Reynisson. (2022). Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. Molecules, 1-14. https://doi.org/10.3390/molecules27030880

The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in... Read More about Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action..

Septal Flash as a Predictor of Cardiac Resynchronization Therapy Response: A Systematic Review and Meta-Analysis (2022)
Journal Article
(2022). Septal Flash as a Predictor of Cardiac Resynchronization Therapy Response: A Systematic Review and Meta-Analysis. Journal of Cardiovascular Echography, 198 - 198

Cardiac resynchronization therapy (CRT) in heart failure patients has been shown to improve patient outcomesin some but not all patients. A few studies have identified that septal flash on imaging is associated with response to CRT, but there has yet... Read More about Septal Flash as a Predictor of Cardiac Resynchronization Therapy Response: A Systematic Review and Meta-Analysis.

A Rare Presentation of a Solitary Melanoma Bone Metastasis. (2022)
Journal Article
Cool. (2022). A Rare Presentation of a Solitary Melanoma Bone Metastasis. Cureus, e21479 - ?. https://doi.org/10.7759/cureus.21479

A 74-year-old woman presented with sudden onset pain and swelling in her right wrist. Plain radiographs showed a pathological fracture through a lytic lesion. The patient had a past medical history of melanoma on her right thigh, which had been excis... Read More about A Rare Presentation of a Solitary Melanoma Bone Metastasis..

Projections of healthy working life expectancy in England to the year 2035 (2022)
Journal Article
Lynch, M., Bucknall, M., Jagger, C., & Wilkie, R. (2022). Projections of healthy working life expectancy in England to the year 2035. https://doi.org/10.1038/s43587-021-00161-0

UK state pension age is rising in response to life expectancy gains but population health and job opportunities may not be sufficient to achieve extended working lives1,2,3. This study aimed to estimate future trends in healthy working life expectanc... Read More about Projections of healthy working life expectancy in England to the year 2035.

Patient pathways in cardiology: Should pharmaceutical and medical device companies care? (2022)
Journal Article
Kwok, C. S., Muntean, E., Muntean, E., Foster, W., & Mallen, C. D. (2022). Patient pathways in cardiology: Should pharmaceutical and medical device companies care?. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 21(1), 57-60. https://doi.org/10.1097/HPC.0000000000000278

A shared goal of patients, providers and the companies that produce new therapies is to have these therapies used according to guidelines. Health services specialize in patient care and may lack the capabilities to take a product from conception thro... Read More about Patient pathways in cardiology: Should pharmaceutical and medical device companies care?.

Conceptualising and Teaching Biomedical Uncertainty to Medical Students: an Exploratory Qualitative Study (2022)
Journal Article
Lukšaitė, E., Fricker, R., McKinley, R., & Dikomitis, L. (2022). Conceptualising and Teaching Biomedical Uncertainty to Medical Students: an Exploratory Qualitative Study. Medical Science Educator, 32, 371–378. https://doi.org/10.1007/s40670-021-01481-x

Introduction Certainty/uncertainty in medicine is a topic of popular debate. This study aims to understand how biomedical uncertainty is conceptualised by academic medical educators and how it is taught in a medical school in the UK. Methods This is... Read More about Conceptualising and Teaching Biomedical Uncertainty to Medical Students: an Exploratory Qualitative Study.

Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis (2022)
Journal Article
Ullah, W., Gul, S., Saleem, S., Syed, M. A., Khan, M. Z., Zahid, S., …Fischman, D. L. (2022). Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis. European Heart Journal Open, 2(1), Article oeac002. https://doi.org/10.1093/ehjopen/oeac002

Aims: Combined mitral valve replacement (MVR) and coronary artery bypass graft (CABG) procedures have been the norm for patients with concomitant mitral valve disease (MVD) and coronary artery disease (CAD) with no large-scale data on their safety an... Read More about Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis.

Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial (2022)
Journal Article
Tunnage, B., Woodhouse, L. J., Dixon, M., Anderson, C., Ankolekar, S., Appleton, J., …Investigators, R. (in press). Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial. BMC Emergency Medicine, 22, Article 2. https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial.

Outcomes and regional differences in practice in a worldwide coronary stent registry (2022)
Journal Article
Mamas. (2022). Outcomes and regional differences in practice in a worldwide coronary stent registry. Heart, https://doi.org/10.1136/heartjnl-2021-320116

Objective: The primary objective was to assess the performance of a new generation thin-strut sirolimus-eluting coronary stent with abluminal biodegradable polymer in an all comer population. The secondary objective was to detail differences in conte... Read More about Outcomes and regional differences in practice in a worldwide coronary stent registry.

Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy (2022)
Journal Article
Darling, D., Farzaneh, F., Williams, G., & Tonge, D. (2022). Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy. Scientific reports, 12, Article 182. https://doi.org/10.1038/s41598-021-03983-5

<jats:title>Abstract</jats:title><jats:p>Identification of cell fate-controlling lncRNAs is essential to our understanding of molecular cell biology. Here we present a human genome-scale forward-genetics approach for the identification of lncRNAs bas... Read More about Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy.

Sweet targets: sugar nucleotide biosynthesis inhibitors. (2022)
Journal Article
Ahmadipour, S., Reynisson, J., Field, R. A., & Miller, G. J. (2022). Sweet targets: sugar nucleotide biosynthesis inhibitors. Future Medicinal Chemistry, 14(5), 295-298. https://doi.org/10.4155/fmc-2021-0286

'Editorial Material'

Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM (2022)
Journal Article
Mottershead, D. (2022). Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM. Journal of Assisted Reproduction and Genetics, 39, Article 127–140. https://doi.org/10.1007/s10815-021-02382-z

PURPOSE: In vitro maturation (IVM) is a technology that generates mature oocytes following culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by minimal patient stimulation, making it attractive for certain patient grou... Read More about Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM.

The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States (2022)
Journal Article
Rashid, Mamas, & Wu. (2022). The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States. Mayo Clinic Proceedings, 88-100. https://doi.org/10.1016/j.mayocp.2021.06.029

Objective
To investigate the utility of Charlson comorbidity index (CCI) as a measure of comorbidity burden to predict procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation.
Methods
All de novo CIED implantati... Read More about The impact of Charlson Comorbidity Index on de novo CIED procedural outcomes in the United States.

Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): study protocol (2022)
Journal Article
Chew-Graham. (2022). Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): study protocol. BJPsych Open, 1-10. https://doi.org/10.1192/bjo.2021.1032

<jats:sec id="S2056472421010322_sec_a1"> <jats:title>Background</jats:title> <jats:p>In the UK, postnatal depression is more common in British South Asian women than White Caucasion women. Cognitive–behavioural therapy (CBT) is recommended as a first... Read More about Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): study protocol.

Side-effect expectations from COVID-19 vaccination: findings from a nationally representative cross-sectional survey (CoVAccS – wave 2) (2022)
Journal Article
Smith, L., Sim, J., Amlôt, R., Cutts, M., Dasch, H., Sevdalis, N., …Sherman, S. (2022). Side-effect expectations from COVID-19 vaccination: findings from a nationally representative cross-sectional survey (CoVAccS – wave 2). Journal of Psychosomatic Research, https://doi.org/10.1016/j.jpsychores.2021.110679

Objectives: Concern about side effects is one of the most common reasons for refusing vaccination. Side-effect expectations are also known to predict perception of side effects. We aimed to investigate the percentage of people who thought side effect... Read More about Side-effect expectations from COVID-19 vaccination: findings from a nationally representative cross-sectional survey (CoVAccS – wave 2).

Entomological survey for identification of Aedes larval breeding sites and their distribution in Chattogram, Bangladesh (2021)
Journal Article
haider. (2021). Entomological survey for identification of Aedes larval breeding sites and their distribution in Chattogram, Bangladesh. Beni-Suef University Journal of Basic and Applied Sciences, 1-11. https://doi.org/10.1186/S43088-021-00122-X

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Studying the characteristics of <jats:italic>Aedes</jats:italic> mosquito habitats is essential to control the mosquito population. The objective of this study wa... Read More about Entomological survey for identification of Aedes larval breeding sites and their distribution in Chattogram, Bangladesh.

Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis (2021)
Thesis
Echrish, J. H. J. (2021). Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis. (Thesis). Keele University

Coronary heart disease is the primary global cause of morbidity and mortality, accounting for about 33% of global deaths in 2013. Atherosclerosis is the principal cause of coronary heart disease and is caused by inflammation of the arterial wall. Thi... Read More about Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis.