The diagnosis and classification of low back-related leg pain
Thesis
Stynes, S. M. (2017). The diagnosis and classification of low back-related leg pain

Low back-related leg pain (LBLP) is clinically diagnosed as referred leg pain or sciatica. The clinical task of differentiating sciatica from referred leg pain can be challenging but is important for the purpose of treatment choices. There is current... Read More about The diagnosis and classification of low back-related leg pain.

Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis.
Thesis
Smith, R. (2017). Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis

Physical activity (PA) is recommended for all adults with osteoarthritis (OA). Adults aged 45 years and over with joint pain, are likely to have already developed OA or are at risk of OA. This thesis examines self-reported PA levels in community dwel... Read More about Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis..

Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models
Thesis
Wulff, J. (2013). Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models

The overall aim of this thesis is to develop prediction models to identify key predictors of poor outcome in people with osteoarthritis (OA) and examine the cost effectiveness of two approaches to delivering primary care interventions for OA compared... Read More about Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models.

Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status
Thesis
Al-Zubaidi, M. A. (2018). Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status

Self-renewal and an ability to differentiate are key hallmarks of stem cells. Pluripotent stem cells (PSC) have the capacity to differentiate into all cell types found within the three germ layers; ectoderm, endoderm, mesoderm. Multipotent stem cells... Read More about Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status.

Small angle scattering studies of chromatin proteins in the human malarial parasite
Thesis
Jordan, A. (2017). Small angle scattering studies of chromatin proteins in the human malarial parasite

This thesis describes the biochemical, biophysical and structural characterisation of two
proteins believed to play an important role in active gene silencing mechanisms present in
the human malarial parasite, Plasmodium falciparum. These investiga... Read More about Small angle scattering studies of chromatin proteins in the human malarial parasite.

Oscillating magnet array-based nanomagnetic gene transfection of mammalian cells relevant to regenerative medicine
Thesis
Fouriki, A. (2017). Oscillating magnet array-based nanomagnetic gene transfection of mammalian cells relevant to regenerative medicine

Successful gene therapy depends upon specific gene delivery into the cells and tissues of interest. Nanomagnetic gene transfection is a relatively new gene delivery technique that has attempted to meet that need and has been effectively used with bot... Read More about Oscillating magnet array-based nanomagnetic gene transfection of mammalian cells relevant to regenerative medicine.

Statistical analysis of longitudinal randomized clinical trials with missing data: a comparison of approaches
Thesis
Joseph, R. (2015). Statistical analysis of longitudinal randomized clinical trials with missing data: a comparison of approaches

Objectives
Missing data represent a source of bias in randomized clinical trials (RCTs). This thesis focuses on pragmatic RCTs with missing continuous outcome data and evaluates the use and appropriateness of current methods of analysis.

Methods... Read More about Statistical analysis of longitudinal randomized clinical trials with missing data: a comparison of approaches.

Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering
Thesis
Rotherham, M. (2016). Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering

The Wnt signalling pathways play crucial roles in development, tissue patterning, and stem cell fate determination. These pathways are therefore an attractive therapeutic target in the field of regenerative medicine and tissue engineering. Magnetic n... Read More about Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering.

Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes
Thesis
metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes

Introduction: Pneumonia contributes significantly to the morbidity and mortality in stroke patients, especially those fed via nasogastric tubes.

Methods: This project was conducted in two steps;
1. A randomised controlled trial: The efficacy of p... Read More about Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes.

Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation
Thesis
Baba Ismail, Y. M. (2016). Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation

The most common clinical treatments for large bone deficiencies resulting from trauma, disease or infection are autograft, allograft or bone graft substitutes (BGS). However, these treatments still have limitations for clinical applications. Thus, th... Read More about Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation.

Novel tissue engineering approaches to enhance natural bone formation
Thesis
Deegan, A. J. (2016). Novel tissue engineering approaches to enhance natural bone formation

The bone tissue engineering community has been striving to develop novel approaches that mimic natural bone formation. The rapid generation of mineralised bone tissue with a capacity for vascularisation and the selection of highly osteogenic cell sou... Read More about Novel tissue engineering approaches to enhance natural bone formation.

Identifying phenotypes and long term course of hand problems in older people using a latent transition approach
Thesis
Green, D. J. (2016). Identifying phenotypes and long term course of hand problems in older people using a latent transition approach

Musculoskeletal conditions of the hand are frequent causes of pain and disability in older people, yet knowledge regarding the characteristics and patterns of hand pain and problems over time is lacking. The objectives of this project were to identif... Read More about Identifying phenotypes and long term course of hand problems in older people using a latent transition approach.

Stroke survivors’ experiences of upper limb dysfunction: a longitudinal exploratory study
Thesis
Purton, J. (2017). Stroke survivors’ experiences of upper limb dysfunction: a longitudinal exploratory study

The experiences of stroke survivors have been researched quite extensively, in particular the effect that stroke can have on a person’s life and sense of self, but how much upper limb dysfunction contributes to these experiences is not fully known. T... Read More about Stroke survivors’ experiences of upper limb dysfunction: a longitudinal exploratory study.

The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering
Thesis
Price, J. C. F. A. (2017). The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering

Current orthopaedics treatments of bone defects often involve the use of implanted fixatives and/or autograft procedures to restore function to the afflicted area following injury. Fixatives and implants are usually temporary solutions, since they ar... Read More about The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering.

Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis
Thesis
Kalra, S. (2017). Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis

Multiple Sclerosis (MS) is one of the commonest disabling neurological diseases affecting the young in the developed world. It affects the central nervous system (CNS) and is characterised by inflammation with neuronal demyelination /degeneration and... Read More about Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis.

Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes
Thesis
Patel, N. (2016). Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes

COPD is a debilitating chronic respiratory disease with a systemic footprint. COPD is a highly heterogeneous disease but invariably its management involves a one-size fits all approach. This fails to address individual variations in disease progressi... Read More about Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes.

Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression
Thesis
Dale, T. P. (2016). Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression

Damaged or diseased mature articular cartilage cannot undergo effective tissue repair and due to its avascular, hypocellular nature defects become widespread and painful. No ‘gold standard’ treatment exists for this indication and the ultimate recour... Read More about Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression.

Explicating and supporting the needs of student nurses during practice placements: a flexible and transferable model developed through action research
Thesis
model developed through action research

This study was designed to identify and address the support needs of pre-registration nursing students during practice placements in the West Midlands region. The study used an action research approach to define student needs and develop a flexible t... Read More about Explicating and supporting the needs of student nurses during practice placements: a flexible and transferable model developed through action research.

Media constructions of 'arthritis': a mixed methods qualitative study
Thesis
Rowley, R. (2016). Media constructions of 'arthritis': a mixed methods qualitative study

Musculoskeletal conditions, including arthritis, have a global impact, causing increased disability and reduced quality of life. Previous research has demonstrated negative attitudes and beliefs about arthritis exist which means the condition is ofte... Read More about Media constructions of 'arthritis': a mixed methods qualitative study.

In search of a system which acquires the maximum number of organs and is consistent with a society's values.
Thesis
Thornton, V. C. (2015). In search of a system which acquires the maximum number of organs and is consistent with a society's values

In 2008, the Organ Donation Taskforce was asked to consider the impact of introducing an opt-out system for organ donation in the United Kingdom. The Taskforce conducted a thorough investigation, which included information gathering from both the pub... Read More about In search of a system which acquires the maximum number of organs and is consistent with a society's values..