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Psychological stress and musculoskeletal pain: the moderating effect of childhood and adulthood trauma
Thesis
Woodward, A. (2015). Psychological stress and musculoskeletal pain: the moderating effect of childhood and adulthood trauma

The aetiology of widespread musculoskeletal pain is complex. Psychological stress is a robust predictor of symptom onset and persistence but not everyone who experiences stress goes on to develop widespread pain. The aim of the studies presented in t... Read More about Psychological stress and musculoskeletal pain: the moderating effect of childhood and adulthood trauma.

Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care
Thesis
Ndlovu, M. (2014). Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care

Musculoskeletal (MSK) pain is a major reason why people consult their general practitioner. Analgesia plays a central role in its treatment but do not always work, resulting in the need to switch amongst analgesia potency levels. Stronger analgesia i... Read More about Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care.

The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale
Thesis
Duncan, K. (2017). The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale

Background: Attitudes and beliefs that healthcare practitioners (HCPs) hold about musculoskeletal (MSK) pain influence their clinical behaviour. The Pain Attitudes and Beliefs Scale (PABS), originally developed for low back pain (LBP), is the most wi... Read More about The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale.

Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index
Thesis
Moody, D. K. (2016). Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index

Frailty measurement in primary care and at transitions of care is needed to enable timely identification of frailty, guide interventions and support proactive, integrated care. However, there is currently no single tool for frailty measurement in the... Read More about Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index.

Shared decision-making around analgesia for musculoskeletal pain in primary care consultations
Thesis
Hyde, C. (2016). Shared decision-making around analgesia for musculoskeletal pain in primary care consultations

Background
Musculoskeletal (MSK) pain is a major health problem worldwide and in UK primary care. Shared decision-making (SDM) is a process advocated by UK policy directives whereby a general practitioner (GP) and patient share information and the... Read More about Shared decision-making around analgesia for musculoskeletal pain in primary care consultations.

Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer
Thesis
Sivakumar, R. (2017). Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer

Cyclin D1 is a key regulatory protein in the progression of G1-S phase of the cell cycle. Activated Cyclin D1 in turn activates S phase proteins and thereby leading to cell proliferation. Over expression of Cyclin D1 leads S phase cell cycle progress... Read More about Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer.

Feasibility of identifying prognostic factors for total joint arthroplasty in electronic primary health care records
Thesis
Turner, M. A. (2017). Feasibility of identifying prognostic factors for total joint arthroplasty in electronic primary health care records

The ability to identify osteoarthritis (OA) patients at high risk of progressing to joint arthroplasty surgery could enable earlier, targeted nonsurgical management in primary care. The ability to do so using only information routinely recorded withi... Read More about Feasibility of identifying prognostic factors for total joint arthroplasty in electronic primary health care records.

Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset
Presentation / Conference
Mamas, & Rashid. Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset. Presented at Transcatheter Cardiovascular Therapeutics

Background This study was designed to evaluate temporal trends in elective rates of percutaneous coronary intervention (PCI) for stable angina and, specifically, to study the impact of the COURAGE and ORBITA trials on real-life practice. Methods We a... Read More about Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset.

Multivariate decoding of EEG data reveals similar mechanisms mediate perceptual adaptation and spontaneous perceptual reversals
Presentation / Conference
Dundas, K., & Brooks, J. Multivariate decoding of EEG data reveals similar mechanisms mediate perceptual adaptation and spontaneous perceptual reversals. Presented at ECVP 2021

The cause of spontaneous perceptual reversals of visually ambiguous stimuli (e.g., Rubin’s faces-vase) has been attributed to several different mechanisms. One hypothesis suggests that adaptation, or “neural fatigue”, builds up while one interpretati... Read More about Multivariate decoding of EEG data reveals similar mechanisms mediate perceptual adaptation and spontaneous perceptual reversals.

Juvenile Chondrocytes: Novel Alternatives for Allogeneic Cell Therapy?
Presentation / Conference
Hulme, C., & Wright, K. Juvenile Chondrocytes: Novel Alternatives for Allogeneic Cell Therapy?. Presented at International Cartilage Regeneration and Joint Preservation Society (ICRS) World Congress 2022

Purpose
Development of novel allogeneic chondrocyte therapies are needed to provide a more widespread, cost-effective cartilage treatment option. Here we investigate the potential of juvenile cartilage sources for allogeneic chondrocyte manufactur... Read More about Juvenile Chondrocytes: Novel Alternatives for Allogeneic Cell Therapy?.

Cell Therapy for Cartilage Repair
Journal Article
McCarthy, H., Perry, J., Hulme, C., Mennan, C., & Wright, K. (in press). Cell Therapy for Cartilage Repair

Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating... Read More about Cell Therapy for Cartilage Repair.