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New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties..

Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for a fully-powered pragmatic randomised controlled trial. (2022)
Journal Article
Chew-Graham. (2022). Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for a fully-powered pragmatic randomised controlled trial. PloS one, e0263856 - ?. https://doi.org/10.1371/journal.pone.0263856

Introduction

Depression is a leading mental health problem worldwide. People with long-term conditions are at increased risk of experiencing depression. The COVID-19 pandemic led to strict social restrictions being imposed across the UK population... Read More about Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for a fully-powered pragmatic randomised controlled trial..

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties.

Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies (2022)
Journal Article
Sim, J., Whelan, G., Smith, B., Moffatt, M., & Littlewood, C. (2022). Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies. Clinical Orthopaedics and Related Research, 480(6), 1061-1074. https://doi.org/10.1097/CORR.0000000000002145

Background
Corticosteroid injection is a very common treatment for individuals experiencing musculoskeletal pain, and it is part of the management of numerous orthopaedic conditions. However, there is concern about offering corticosteroid injections... Read More about Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies.

Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression (2022)
Journal Article
Mamas. (2022). Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression. American Journal of Cardiology, https://doi.org/10.1016/j.amjcard.2022.01.045

There are limited data on the clinical outcomes of percutaneous coronary intervention (PCI) in patients with acquired immunosuppression who are frequently underrepresented in clinical trials. All PCI procedures between October 2015 and December 2018... Read More about Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression.

Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial (2022)
Journal Article
Mamas. (2022). Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial. European Heart Journal - Cardiovascular Pharmacotherapy, 149 - 156. https://doi.org/10.1093/ehjcvp/pvab031

Aims Uncontrolled blood pressure (BP) increases the risk of developing heart failure (HF). The effect of spironolactone on BP of patients at risk of developing HF is yet to be determined. To evaluate the effect of spironolactone on the BP of patients... Read More about Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial.

A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation (2022)
Journal Article
Paskins. (2022). A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation. Age and ageing, https://doi.org/10.1093/ageing/afac031

Background: Osteoporotic vertebral fractures (OVFs) identify people at high risk of future fractures, but despite this, less than a third come to clinical attention. The objective of this study was to develop a clinical tool to aid healthcare profess... Read More about A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article
Barreto, S., Al-Zubaidi, M., Dale, T., Worrall, A., Kapacee, Z., Kimber, S., …Rutter, A. (2022). Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency. Preprints, https://doi.org/10.20944/preprints202203.0143.v1

<jats:p>Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improv... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.

Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses (2022)
Journal Article
Bastounis, A., Langley, T., Davis, S., Paskins, Z., Gittoes, N., Leonardi‐Bee, J., & Sahota, O. (2022). Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses. JBMR Plus, 6(5), S270 - S270. https://doi.org/10.1002/jbm4.10620

Bisphosphonates have been found to be effective in preventing fragility fractures. However, their comparative effectiveness in populations at risk has yet to be defined. In light of recent clinical trials, we aimed to compare four bisphosphonates (al... Read More about Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses.

Quantifying the shrinkage of laryngeal laser excisions: a case control study (2022)
Journal Article
(2022). Quantifying the shrinkage of laryngeal laser excisions: a case control study. Journal of Laryngology and Otology, 1 - 25. https://doi.org/10.1017/s0022215122000652

Introduction
Heat from transoral laser microsurgery can cause tissue shrinkage, impacting the surgical margin. The aim of this study was to compare shrinkage between cold steel and carbon dioxide laser resections of laryngeal lesions.

Materials... Read More about Quantifying the shrinkage of laryngeal laser excisions: a case control study.

A community-sourced glossary of open scholarship terms. (2022)
Journal Article
(2022). A community-sourced glossary of open scholarship terms. Nature Human Behaviour, 312-318. https://doi.org/10.1038/s41562-021-01269-4

Open scholarship has transformed research, and introduced a host of new terms in the lexicon of researchers. The ‘Framework for Open and Reproducible Research Teaching’ (FORRT) community presents a crowdsourced glossary of open scholarship terms to f... Read More about A community-sourced glossary of open scholarship terms..

Diagnostic delay in axial spondyloarthritis: a systematic review (2022)
Journal Article
Hay, C., Packham, J., Ryan, S., Mallen, C., Chatzixenitidis, A., & Prior, J. (2022). Diagnostic delay in axial spondyloarthritis: a systematic review. Clinical Rheumatology, 41(1939–1950), https://doi.org/10.1007/s10067-022-06100-7

Identification of axial spondyloarthritis (axSpA) remains challenging, frequently resulting in a diagnostic delay for patients. Current benchmarks of delay are usually reported as mean data, which are typically skewed and therefore may be overestimat... Read More about Diagnostic delay in axial spondyloarthritis: a systematic review.

MASTREE+: time-series of plant reproductive effort from six continents. (2022)
Journal Article
(2022). MASTREE+: time-series of plant reproductive effort from six continents. Global Change Biology, 3066-3082. https://doi.org/10.1111/gcb.16130

Significant gaps remain in understanding the response of plant reproduction to environmental change. This is partly because measuring reproduction in long-lived plants requires direct observation over many years and such datasets have rarely been mad... Read More about MASTREE+: time-series of plant reproductive effort from six continents..

Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic (2022)
Journal Article
(2022). Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic. Advances in therapy, https://doi.org/10.1007/s12325-022-02056-x

The COVID-19 pandemic has brought a renewed focus on appropriate management of chronic respiratory conditions with a heightened awareness of respiratory symptoms and the requirement for differential diagnosis between an asthma attack and COVID-19 inf... Read More about Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic.

Student assistantship programme: an evaluation of impact on readiness to transit from medical student to junior doctor. (2022)
Journal Article
(2022). Student assistantship programme: an evaluation of impact on readiness to transit from medical student to junior doctor. BMC Medical Education, 99 - ?. https://doi.org/10.1186/s12909-022-03159-3

BACKGROUND: Studies report that medical graduates are not prepared for practice as expected, and interventions have been developed to prepare them for practice. One such intervention is the assistantship, which provides hands-on opportunities to hone... Read More about Student assistantship programme: an evaluation of impact on readiness to transit from medical student to junior doctor..

Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study (2022)
Journal Article
Mamas, M. A., Sanghavi, R., Pana, T. A., Mamayusupova, H., Maidment, I., Fox, C., …Myint, P. K. (2022). Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study. British Journal of Clinical Pharmacology, 88(7), 3297-3306. https://doi.org/10.1111/bcp.15261

Background
Higher medication anticholinergic burden is associated with increased risk of cardiovascular disease and cognitive decline. A mechanistic pathway has not been established. We aimed to determine whether inflammation may mediate these assoc... Read More about Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study.

Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats (2022)
Journal Article
Okokon, J. E., Davies, K., John, L., Iwara, K., Li, W.-W., & Thomas, P. S. (2022). Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats. Phytomedicine Plus, https://doi.org/10.1016/j.phyplu.2021.100182

Background
Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a grass used ethnomedically by herbalists in Nigeria for the treatment of diabetes was evaluated for antidiabetic, hypolipidemic and pancreas protective potentials in rats.

Methods
So... Read More about Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats.

Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile. (2022)
Journal Article
Reynisson. (2022). Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile. Journal of Medicinal Chemistry, 2238 - 2261. https://doi.org/10.1021/acs.jmedchem.1c01740

A series of latonduine and indoloquinoline derivatives HL1-HL8 and their copper(II) complexes (1-8) were synthesized and comprehensively characterized. The structures of five compounds (HL6, [CuCl(L1)(DMF)]·DMF, [CuCl(L2)(CH3OH)], [CuCl(L3)]·0.5H2O,... Read More about Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile..