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Sacroiliac joint pain: what treatment and when. (2024)
Journal Article
Cocconi, F., Maffulli, N., Bell, A., Memminger, M. K., Simeone, F., & Migliorini, F. (in press). Sacroiliac joint pain: what treatment and when. Expert Review of Neurotherapeutics, 1-8. https://doi.org/10.1080/14737175.2024.2400682

Spinal and non-spinal pathologies can cause low back pain. Non-spinal sources of low back pain include the sacroiliac joint (SIJ) and the hip. SIJ pain can be treated either conservatively or surgically. Current strategies for managing sacroiliac joi... Read More about Sacroiliac joint pain: what treatment and when..

Pharmacological management of secondary chronic spinal cord injury: a systematic review (2024)
Journal Article
Migliorini, F., Cocconi, F., Schäfer, L., Simeone, F., Jeyaraman, M., & Maffulli, N. (2024). Pharmacological management of secondary chronic spinal cord injury: a systematic review. British Medical Bulletin, 151(1), 49–68. https://doi.org/10.1093/bmb/ldae009

Introduction Spinal cord injury (SCI) may bring lifelong consequences for affected patients and a high financial burden to the health care system. Source of data Published peer-reviewed scientific articles identified from EMBASE, Google Scholar, PubM... Read More about Pharmacological management of secondary chronic spinal cord injury: a systematic review.

Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review (2024)
Journal Article
Jeyaraman, N., Migliorini, F., Murugan, S., Ramasubramanian, S., Balaji, S., Maffulli, N., & Jeyaraman, M. (in press). Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review. Journal of Clinical Medicine, 13(16), Article 4794. https://doi.org/10.3390/jcm13164794

Metamizole, or dipyrone, has been used for decades as a non-narcotic analgesic, providing pain relief from musculoskeletal disorders and antipyretic and antispasmolytic properties. Despite being in use since the 1920s, its mechanism of action still n... Read More about Metamizole in the Management of Musculoskeletal Disorders: Current Concept Review.

Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. (2024)
Journal Article
Ebrahim, N., Al Saihati, H. A., Alali, Z., Aleniz, F. Q., Mahmoud, S. Y. M., Badr, O. A., …Alsabeelah, N. F. (2024). Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. Biomedicine and Pharmacotherapy, 176, Article 116836. https://doi.org/10.1016/j.biopha.2024.116836

Alzheimer's disease (AD) is a devastating neurological condition characterized by cognitive decline, motor coordination impairment, and amyloid plaque accumulation. The underlying molecular mechanisms involve oxidative stress, inflammation, and neuro... Read More about Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway..

Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study. (2024)
Journal Article
Ali, A. M. S., Gul, W., Sen, J., Hewitt, S.-J., Olubajo, F., & McMahon, C. (in press). Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study. Clinical Neurology and Neurosurgery, 239, Article 108215. https://doi.org/10.1016/j.clineuro.2024.108215

Assessment of the pupillary light reflex (PLR) is key in intensive care monitoring of neurosurgical patients, particularly for monitoring intracranial pressure (ICP). Quantitative pupillometry using a handheld pupillometer is a reliable method for PL... Read More about Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study..

Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm (2023)
Journal Article
Philp, F., Meilak, E., Willis, T., Winn, N., & Pandyan, A. (in press). Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm. Gait & Posture, 106, S163-S164. https://doi.org/10.1016/j.gaitpost.2023.07.197

Introduction
Facioscapulohumeral dystrophy (FSHD) can affect upper-limb function through muscle degeneration, fatty infiltration and oedema. Muscle echogenicity, measured using ultrasound, could be used as a bioma... Read More about Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm.

Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee (2021)
Thesis
Hopkins, T. (2021). Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee. (Thesis). Keele University

Damage to the articular cartilage (AC) in the human knee, caused by physical trauma or degenerative disease, represents a common and complex clinical problem. AC has a very limited capacity for self-repair and, once damaged, rarely heals spontaneousl... Read More about Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee.

Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation (2020)
Thesis
Berry, J. D. (2020). Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation. (Thesis). Keele University

Interprofessional education (IPE) has been proposed as a method of creating a collaborative practice ready workforce in healthcare. Postulated benefits of the technique include improving communication between professional groups, which in turn should... Read More about Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation.

Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum (2019)
Thesis
Hmoud, M. K. (2019). Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414945

Despite the efforts in malaria eradication and elimination, malaria still poses a global challenge to health that, through the spread of antimalarial resistance, highlights an urgent need for new approaches for malaria treatment. Heparin and sulphate... Read More about Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum.

A urinary proteomics investigation of pregnancy-related complications (2019)
Thesis
Al-Jasim, W. F. (2019). A urinary proteomics investigation of pregnancy-related complications. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414917

Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are common disorders associated with placental implantation abnormalities in early pregnancy. Both conditions are heterogeneous, having complex and multiple aetiologies. PE complicates 5-8... Read More about A urinary proteomics investigation of pregnancy-related complications.

Applied statistical methods for prediction modelling of upper limb functional recovery after stroke (2019)
Thesis
Al-Shallawi, A. N. S. (2019). Applied statistical methods for prediction modelling of upper limb functional recovery after stroke. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414444

Stroke is the third largest cause of death in the world, with a significant contribution to disability. Motor function impairment, encompassing upper limb impairment, is the most significant post-stroke impairment. Such an impairment contributes to r... Read More about Applied statistical methods for prediction modelling of upper limb functional recovery after stroke.

Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs) (2019)
Thesis
Sykes, J. G. (2019). Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs). (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414327

Autologous chondrocyte implantation (ACI) is the only UK approved cell therapy or knee cartilage defects which might otherwise progress to osteoarthritis. For ACI, chondrocytes isolated from a healthy cartilage biopsy are expanded in number prior to... Read More about Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs).

Engineering and optimising a functional in vitro model of basal ganglia circuitry (2019)
Thesis
Kӧse-Dunn, M. J. (2019). Engineering and optimising a functional in vitro model of basal ganglia circuitry. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413812

The majority of neurological diseases (such as Parkinson’s and Huntington’s diseases) are progressive, debilitating and currently incurable. In an ageing population, the prevalence of such diseases will only increase over time, creating a need for be... Read More about Engineering and optimising a functional in vitro model of basal ganglia circuitry.

Characterising microglial activation: refinement and validation of primary in vitro models (2019)
Thesis
Al-Shaheeb, S. (2019). Characterising microglial activation: refinement and validation of primary in vitro models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413772

Background: Neuroinflammation is common to many neurodegenerative conditions and is principally mediated by microglia. Microglia maintain homeostasis, respond to trauma/infection and can promote repair. This is achieved by switching between surveilla... Read More about Characterising microglial activation: refinement and validation of primary in vitro models.

Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells (2019)
Thesis
Ibrahim, . S. L. (2019). Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413776

Breast cancer is considered the most frequently diagnosed cancer in women and the second most common type of cancer causing deaths among women. It is accounts 25% of all female cancers. It is expected about 1 in 8 women will develop this disease duri... Read More about Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells.

Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders (2019)
Thesis
Hmeidi, H. (2019). Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413771

Current Lung function assessments in children can be clinically challenging and even inapplicable in preschool children, this is due to the test requirements of cooperation and understanding. Hence, there is a need for new techniques that can overcom... Read More about Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders.

Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis (2019)
Thesis
Moran, J. A. (2019). Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413132

The research described here considers molecular variations of the acute phase response protein, C reactive protein (CRP), and the presence of CRP and anti CRP autoantibodies in rheumatoid arthritis (RA) patient serum.
Monomeric CRP (mCRP) was genera... Read More about Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis.

A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials (2018)
Thesis
Potts, J. E. (2018). A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412318

Most analyses in stroke clinical trials assess the primary outcome at a single time point and do not consider conducting a longitudinal analysis, even when the outcome has been recorded at several time points. Efforts to improve the quality of statis... Read More about A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials.

Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach (2018)
Thesis
AL-Jumaily, R. M. K. (2018). Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412295

Oxygen is an essential factor for life in many organisms. Oxygen concentrations vary widely across different human tissues, but in general, are much lower than the 21% oxygen in atmospheric air. In spite of this, most research continues to be based o... Read More about Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach.

Investigation of cellular and scaffold strategies for engineering articular cartilage (2018)
Thesis
Abu Owida, H. (2018). Investigation of cellular and scaffold strategies for engineering articular cartilage. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412022

Articular cartilage is a thin hydrated tissue, which covers articulating surfaces. In the native articular cartilage tissue, the extracellular matrix (ECM) is a fibrillar mesh of interacting proteoglycans, collagens, and other non-collagenous protein... Read More about Investigation of cellular and scaffold strategies for engineering articular cartilage.