Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles (2024)
Thesis
Fernando, B. L. (2024). Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/855660

Introduction
Patients with medically unexplained symptoms (MUS), i.e., physical complaints not fully explained by somatic/psychiatric pathology, are well-documented as a significant problem in primary care. Yet, the issues these patients and their... Read More about Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles.

Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis (2024)
Thesis
Hay, C. A. (2024). Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775300

Background: Axial spondyloarthritis (axSpA) causes inflammation of the pelvis and spine, resulting in chronic pain, impaired range of movement, fatigue and physical disability. Diagnosis remains challenging and is frequently delayed, resulting in poo... Read More about Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis.

Complex, high-risk but Indicated Percutaneous Coronary Interventions (CHiP) types, trends, and clinical outcomes (2024)
Thesis
Al-Shamkhani, W. S. J. (2024). Complex, high-risk but Indicated Percutaneous Coronary Interventions (CHiP) types, trends, and clinical outcomes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775413

Coronary artery disease ( CAD) remains the leading cause of death worldwide. Medical therapy and lifestyle modifications are the first line of therapy to minimise symptoms and retard disease progression. An Invasive therapy in the form of percutaneou... Read More about Complex, high-risk but Indicated Percutaneous Coronary Interventions (CHiP) types, trends, and clinical outcomes.

The association between gout and psychological co-morbidity: results from a prospective cohort study (2023)
Thesis
Higgs, J. J. R. (2023). The association between gout and psychological co-morbidity: results from a prospective cohort study. (Thesis). Keele University

Gout is associated with an increased risk of both physical-health co-morbidities and a reduction in physical health-related quality of life. However, the association between gout and psychological comorbidity (depression and anxiety) has received lit... Read More about The association between gout and psychological co-morbidity: results from a prospective cohort study.

An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells (2022)
Thesis
Kavousi, N. (2022). An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells. (Thesis). Keele University

The serine/threonine protein phosphatase 4 holoenzyme consists of PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits (PP4R1, PP4R2, PP4R3, PP4R4). Previous studies have shown that PP4c acts as a tumour suppressor an... Read More about An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells.

Developing tools for inter-site transport of brain tissue models in tissue engineering research (2022)
Thesis
Kabiri, B. (2022). Developing tools for inter-site transport of brain tissue models in tissue engineering research. (Thesis). Keele University

Penetrating traumatic brain injury (pTBI) remains one of the leading causes of death in the younger population in the UK, as no clinical regenerative therapies are available. Experimental therapies currently being screened for efficacy are wide rangi... Read More about Developing tools for inter-site transport of brain tissue models in tissue engineering research.

Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records (2022)
Thesis
Dyer, B. P. (2022). Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records. (Thesis). Keele University

Introduction
Frozen shoulder, a condition that can cause prolonged pain and disability, has previously been found to be common amongst people with diabetes. This thesis aimed to improve the understanding of the nature of the relationship between dia... Read More about Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records.

Practice Readiness: An English exploratory study describing newly qualified graduate nurses’ perceptions of practice readiness and professional identity (2022)
Thesis
Sargeant, K. E. (2022). Practice Readiness: An English exploratory study describing newly qualified graduate nurses’ perceptions of practice readiness and professional identity. (Thesis). Keele University

Background: Greater understanding of NQNs’ perceptions of their pre-registration and transition experiences, and influences on their perceptions can inform pre-registration curricula and preceptorship programmes to support a positive transition to qu... Read More about Practice Readiness: An English exploratory study describing newly qualified graduate nurses’ perceptions of practice readiness and professional identity.

Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica (2022)
Thesis
Twohig, H. J. (2022). Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica. (Thesis). Keele University

Background
Polymyalgia rheumatica (PMR) causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient’s perspective is vital to highquality research and patient-centred care, yet there are no validated... Read More about Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica.

Aerobic exercise to improve cardiorespiratory function in Parkinson's (2021)
Thesis
Aburub, A. (2021). Aerobic exercise to improve cardiorespiratory function in Parkinson's. (Thesis). Keele University

Introduction
Cardiopulmonary impairments are the leading cause of morbidity and mortality in advanced stages of Parkinson’s. Although there is some evidence of pulmonary impairments in the earlier stages, symptoms remain asymptomatic until advanced... Read More about Aerobic exercise to improve cardiorespiratory function in Parkinson's.

Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis (2021)
Thesis
Echrish, J. H. J. (2021). Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis. (Thesis). Keele University

Coronary heart disease is the primary global cause of morbidity and mortality, accounting for about 33% of global deaths in 2013. Atherosclerosis is the principal cause of coronary heart disease and is caused by inflammation of the arterial wall. Thi... Read More about Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis.

Automated Check-in Data Collection (AC DC): an investigation of utility, acceptability and effectiveness in general practice (2021)
Thesis
Lawton, S. A. (2021). Automated Check-in Data Collection (AC DC): an investigation of utility, acceptability and effectiveness in general practice. (Thesis). Keele University

Background: There are a range of data collection methodologies employed for collecting patient health related research data. Within primary care settings, and particularly within general practice, time and resources are limited. The utility of an aut... Read More about Automated Check-in Data Collection (AC DC): an investigation of utility, acceptability and effectiveness in general practice.

Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study (2021)
Thesis
Mughal, F. H. (2021). Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study. (Thesis). Keele University

Self-harm in young people is a national priority. General practitioners see young people who self-harm the most often in the National Health Service (NHS), and episodes of self-harm in young people presenting to general practice are rising. General p... Read More about Examining the potential of general practice to support young people with self-harm behaviour: a systematic review and qualitative study.

Evaluation of surgical outcomes using administrative hospital data (2021)
Thesis
El-Dhuwaib, Y. (2021). Evaluation of surgical outcomes using administrative hospital data. (Thesis). Keele University

Hospital Episode Statistics (HES) is the main hospital administrative dataset in England. Since the early 1990s HES has been used for research. The aim of the thesis is to evaluate the use of HES data to measure surgical outcomes.

Objectives:
1.... Read More about Evaluation of surgical outcomes using administrative hospital data.

Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee (2021)
Thesis
Hopkins, T. (2021). Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee. (Thesis). Keele University

Damage to the articular cartilage (AC) in the human knee, caused by physical trauma or degenerative disease, represents a common and complex clinical problem. AC has a very limited capacity for self-repair and, once damaged, rarely heals spontaneousl... Read More about Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee.

The association between osteoarthritis and invasive management strategies and clinical outcomes following acute myocardial infarction in electronic health record data (2020)
Thesis
Parmar, S. S. (2020). The association between osteoarthritis and invasive management strategies and clinical outcomes following acute myocardial infarction in electronic health record data. (Thesis). Keele University

Background
The association between osteoarthritis (OA) and acute myocardial infarction (AMI) is unclear, as are the outcomes of people with OA diagnosed with AMI. This study aimed to describe the annual prevalence of OA among AMI patients and descri... Read More about The association between osteoarthritis and invasive management strategies and clinical outcomes following acute myocardial infarction in electronic health record data.

Exploration of the use of decision analytic modelling in low back pain and sciatica (2020)
Thesis
Ashwell Hall, J. (2020). Exploration of the use of decision analytic modelling in low back pain and sciatica. (Thesis). Keele University

Low back pain (LBP) is a global public health problem. Keele University developed the STarT Back tool to stratify LBP patients according to their risk of persistent disability, matching treatments to individual risk. A 12-month trial-based economic e... Read More about Exploration of the use of decision analytic modelling in low back pain and sciatica.

Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study (2020)
Thesis
Machin, A. R. (2020). Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study. (Thesis). Keele University

Background
Mood problems in people with rheumatoid arthritis (RA) are under-recognised and treated, contributing to increased mortality. Comorbid depression is associated with increased disease activity and reduced quality of life (QoL), though the... Read More about Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study.

Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation (2020)
Thesis
Berry, J. D. (2020). Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation. (Thesis). Keele University

Interprofessional education (IPE) has been proposed as a method of creating a collaborative practice ready workforce in healthcare. Postulated benefits of the technique include improving communication between professional groups, which in turn should... Read More about Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation.

Understanding self-harm behaviour in older adults: a systematic review and qualitative study (2019)
Thesis
Troya Bermeo, M. I. (2019). Understanding self-harm behaviour in older adults: a systematic review and qualitative study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415218

Two worldwide challenges served as a drive for this research: the reality of an ageing population and the identified need of supporting people who self-harm. Addressing self-harm has been increasingly prioritised due to its social, economic and healt... Read More about Understanding self-harm behaviour in older adults: a systematic review and qualitative study.