Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering
Thesis
Rotherham, M. (2016). Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering

The Wnt signalling pathways play crucial roles in development, tissue patterning, and stem cell fate determination. These pathways are therefore an attractive therapeutic target in the field of regenerative medicine and tissue engineering. Magnetic n... Read More about Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering.

Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes
Thesis
metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes

Introduction: Pneumonia contributes significantly to the morbidity and mortality in stroke patients, especially those fed via nasogastric tubes.

Methods: This project was conducted in two steps;
1. A randomised controlled trial: The efficacy of p... Read More about Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes.

Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation
Thesis
Baba Ismail, Y. M. (2016). Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation

The most common clinical treatments for large bone deficiencies resulting from trauma, disease or infection are autograft, allograft or bone graft substitutes (BGS). However, these treatments still have limitations for clinical applications. Thus, th... Read More about Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation.

Novel tissue engineering approaches to enhance natural bone formation
Thesis
Deegan, A. J. (2016). Novel tissue engineering approaches to enhance natural bone formation

The bone tissue engineering community has been striving to develop novel approaches that mimic natural bone formation. The rapid generation of mineralised bone tissue with a capacity for vascularisation and the selection of highly osteogenic cell sou... Read More about Novel tissue engineering approaches to enhance natural bone formation.

Identifying phenotypes and long term course of hand problems in older people using a latent transition approach
Thesis
Green, D. J. (2016). Identifying phenotypes and long term course of hand problems in older people using a latent transition approach

Musculoskeletal conditions of the hand are frequent causes of pain and disability in older people, yet knowledge regarding the characteristics and patterns of hand pain and problems over time is lacking. The objectives of this project were to identif... Read More about Identifying phenotypes and long term course of hand problems in older people using a latent transition approach.

Stroke survivors’ experiences of upper limb dysfunction: a longitudinal exploratory study
Thesis
Purton, J. (2017). Stroke survivors’ experiences of upper limb dysfunction: a longitudinal exploratory study

The experiences of stroke survivors have been researched quite extensively, in particular the effect that stroke can have on a person’s life and sense of self, but how much upper limb dysfunction contributes to these experiences is not fully known. T... Read More about Stroke survivors’ experiences of upper limb dysfunction: a longitudinal exploratory study.

The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering
Thesis
Price, J. C. F. A. (2017). The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering

Current orthopaedics treatments of bone defects often involve the use of implanted fixatives and/or autograft procedures to restore function to the afflicted area following injury. Fixatives and implants are usually temporary solutions, since they ar... Read More about The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering.

An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells
Thesis
Al-Mayyahi, R. S. (2017). An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells

Anti-inflammatory drugs such as corticosteroids (CSs) and minocycline (MINO) are widely used in the treatment of a range of clinical conditions and to suppress graft rejection in stem cell transplantation therapy. However, such treatment is associate... Read More about An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells.

Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes
Thesis
Patel, N. (2016). Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes

COPD is a debilitating chronic respiratory disease with a systemic footprint. COPD is a highly heterogeneous disease but invariably its management involves a one-size fits all approach. This fails to address individual variations in disease progressi... Read More about Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes.

Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression
Thesis
Dale, T. P. (2016). Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression

Damaged or diseased mature articular cartilage cannot undergo effective tissue repair and due to its avascular, hypocellular nature defects become widespread and painful. No ‘gold standard’ treatment exists for this indication and the ultimate recour... Read More about Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression.

Explicating and supporting the needs of student nurses during practice placements: a flexible and transferable model developed through action research
Thesis
model developed through action research

This study was designed to identify and address the support needs of pre-registration nursing students during practice placements in the West Midlands region. The study used an action research approach to define student needs and develop a flexible t... Read More about Explicating and supporting the needs of student nurses during practice placements: a flexible and transferable model developed through action research.

Media constructions of 'arthritis': a mixed methods qualitative study
Thesis
Rowley, R. (2016). Media constructions of 'arthritis': a mixed methods qualitative study

Musculoskeletal conditions, including arthritis, have a global impact, causing increased disability and reduced quality of life. Previous research has demonstrated negative attitudes and beliefs about arthritis exist which means the condition is ofte... Read More about Media constructions of 'arthritis': a mixed methods qualitative study.

Attitudes, beliefs and physical activity in older adults with knee pain
Thesis
Quicke, J. (2016). Attitudes, beliefs and physical activity in older adults with knee pain

Knee pain in older adults is common and often disabling, with the majority of knee pain in adults over the age of 45 being attributed to osteoarthritis (OA). Regular physical activity and exercise are recommended for all older adults with knee pain a... Read More about Attitudes, beliefs and physical activity in older adults with knee pain.

A study of pain and mortality: the role of lifestyle, health, social and psychological factors
Thesis
Smith, D. (2016). A study of pain and mortality: the role of lifestyle, health, social and psychological factors

Background
Moderate to severe chronic pain affects one in five of adults. The prevalence and impact of pain increase with age. Pain may increase the risk of mortality but the relationship is not clear.

Aims
To test the hypothesis that pain incre... Read More about A study of pain and mortality: the role of lifestyle, health, social and psychological factors.

Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care
Thesis
Ndlovu, M. (2014). Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care

Musculoskeletal (MSK) pain is a major reason why people consult their general practitioner. Analgesia plays a central role in its treatment but do not always work, resulting in the need to switch amongst analgesia potency levels. Stronger analgesia i... Read More about Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care.

The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale
Thesis
Duncan, K. (2017). The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale

Background: Attitudes and beliefs that healthcare practitioners (HCPs) hold about musculoskeletal (MSK) pain influence their clinical behaviour. The Pain Attitudes and Beliefs Scale (PABS), originally developed for low back pain (LBP), is the most wi... Read More about The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale.

Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index
Thesis
Moody, D. K. (2016). Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index

Frailty measurement in primary care and at transitions of care is needed to enable timely identification of frailty, guide interventions and support proactive, integrated care. However, there is currently no single tool for frailty measurement in the... Read More about Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index.

Shared decision-making around analgesia for musculoskeletal pain in primary care consultations
Thesis
Hyde, C. (2016). Shared decision-making around analgesia for musculoskeletal pain in primary care consultations

Background
Musculoskeletal (MSK) pain is a major health problem worldwide and in UK primary care. Shared decision-making (SDM) is a process advocated by UK policy directives whereby a general practitioner (GP) and patient share information and the... Read More about Shared decision-making around analgesia for musculoskeletal pain in primary care consultations.

Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer
Thesis
Sivakumar, R. (2017). Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer

Cyclin D1 is a key regulatory protein in the progression of G1-S phase of the cell cycle. Activated Cyclin D1 in turn activates S phase proteins and thereby leading to cell proliferation. Over expression of Cyclin D1 leads S phase cell cycle progress... Read More about Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer.

Feasibility of identifying prognostic factors for total joint arthroplasty in electronic primary health care records
Thesis
Turner, M. A. (2017). Feasibility of identifying prognostic factors for total joint arthroplasty in electronic primary health care records

The ability to identify osteoarthritis (OA) patients at high risk of progressing to joint arthroplasty surgery could enable earlier, targeted nonsurgical management in primary care. The ability to do so using only information routinely recorded withi... Read More about Feasibility of identifying prognostic factors for total joint arthroplasty in electronic primary health care records.