Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach. (2024)
Journal Article
Chew, N. W. S., Mehta, A., Goh, R. S. J., Zhang, A., Chen, Y., Chong, B., …Sperling, L. S. (2025). Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach. Circulation, 151(1), 98-119. https://doi.org/10.1161/CIRCULATIONAHA.124.070535

There is a new awareness of the widespread nature of metabolic dysfunction-associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrino... Read More about Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach..

How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey. (2024)
Journal Article
Murphy, A. C., Carroll, W., Gotsell, M., Potter, C., Quint, J. K., & Malone, R. (in press). How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey. BMJ Open Respiratory Research, 11(1), e002579. https://doi.org/10.1136/bmjresp-2024-002579

Inhalers are widely used for the management of asthma and chronic obstructive pulmonary disease. However, there is little knowledge about the extent to which an inhaler is used and when it is disposed of, despite the implications for an individual's... Read More about How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey..

Correction: Addressing disparities in the long-term mortality risk in individuals with non-ST segment myocardial infarction (NSTEMI) by diabetes mellitus status: a nationwide cohort study. (2024)
Journal Article
Cole, A., Weight, N., Misra, S., Grapsa, J., Rutter, M. K., Siudak, Z., …Mamas, M. A. (in press). Correction: Addressing disparities in the long-term mortality risk in individuals with non-ST segment myocardial infarction (NSTEMI) by diabetes mellitus status: a nationwide cohort study. Diabetologia, https://doi.org/10.1007/s00125-024-06337-8

A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides (2024)
Journal Article
Shen, Z., Simard, M., Brand, D., Andrei, V., Al-Khader, A., Oumlil, F., …Collins-Fekete, C.-A. (in press). A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides. Communications Biology, 7(1), 1674. https://doi.org/10.1038/s42003-024-07398-6

Mitotic activity is an important feature for grading several cancer types. However, counting mitotic figures (cells in division) is a time-consuming and laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incor... Read More about A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides.

Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA) (2024)
Journal Article
Yeates, P., & McCray, G. (in press). Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA). BMC Medical Education, 24(1), 1466. https://doi.org/10.1186/s12909-024-06462-3

Introduction: Ensuring examiner equivalence across distributed assessment locations is a priority within distributed Objective Structured Clinical Exams (OSCEs) but is challenging as examiners are typically fully nested within locations (i.e. no over... Read More about Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA).

Cardiovascular events in patients with gout initiating urate-lowering therapy with or without colchicine for flare prophylaxis: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data. (2024)
Journal Article
Cipolletta, E., Nakafero, G., McCormick, N., Yokose, C., Avery, A. J., Mamas, M. A., …Abhishek, A. (in press). Cardiovascular events in patients with gout initiating urate-lowering therapy with or without colchicine for flare prophylaxis: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data. The Lancet Rheumatology, 1-12. https://doi.org/10.1016/S2665-9913%2824%2900248-0

Initiating urate-lowering therapy can trigger gout flares. Gout flares have been associated with a temporally increased risk of cardiovascular events. Therefore, we aimed to estimate the risk of cardiovascular events in patients with gout initiating... Read More about Cardiovascular events in patients with gout initiating urate-lowering therapy with or without colchicine for flare prophylaxis: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data..

Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. (2024)
Journal Article
Migliorini, F., Schäfer, L., Pilone, M., Bell, A., Simeone, F., & Maffulli, N. (in press). Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Archives of Orthopaedic and Trauma Surgery, 145(1), 68. https://doi.org/10.1007/s00402-024-05614-w

The present meta-analysis compared the efficacy of intra-articular hyaluronic acid (HA) injections in patients with early to mild knee osteoarthritis (OA) (Kellgren Lawrence I-II) versus other commonly injected biologically active compounds using pat... Read More about Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis..

Intravascular Ultrasound‐Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review, Meta‐Analysis, and Meta‐Regression of Randomized Control Trials (2024)
Journal Article
Ahmed, M., Nadeem, Z. A., Ahsan, A., Javaid, H., Jain, H., Shahid, F., …Mamas, M. A. (in press). Intravascular Ultrasound‐Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review, Meta‐Analysis, and Meta‐Regression of Randomized Control Trials. Catheterization and Cardiovascular Interventions, 105(1), 68-271. https://doi.org/10.1002/ccd.31352

ABSTRACTBackgroundIntravascular ultrasound (IVUS) guidance during percutaneous coronary intervention (PCI) allows better assessment of coronary artery lesion characteristics than angiography alone. This systematic review and meta‐analysis aimed to co... Read More about Intravascular Ultrasound‐Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review, Meta‐Analysis, and Meta‐Regression of Randomized Control Trials.

Disparities in Peripheral Artery Disease-related Mortality in Chronic Inflammatory Disease in the United States from 1999 to 2020 (2024)
Journal Article
Olson, A., Pham, H. N., Ibrahim, R., Salih, M., Singh, A., & Mamas, M. A. (2024). Disparities in Peripheral Artery Disease-related Mortality in Chronic Inflammatory Disease in the United States from 1999 to 2020. Current Cardiology Reviews, 21, Article e1573403X353038. https://doi.org/10.2174/011573403x353038241125050631

Introduction: Peripheral arterial disease (PAD) is a marker of significant atherosclerotic cardiovascular disease and is associated with greater healthcare burden and worse prognosis in individuals with chronic inflammatory disease (CID). We aimed to... Read More about Disparities in Peripheral Artery Disease-related Mortality in Chronic Inflammatory Disease in the United States from 1999 to 2020.

The digital prescription: A systematic review and meta-analysis of smartphone apps for blood pressure control. (2024)
Journal Article
Motta-Yanac, E., Riley, V., Ellis, N. J., Mankoo, A., & Gidlow, C. J. (in press). The digital prescription: A systematic review and meta-analysis of smartphone apps for blood pressure control. International Journal of Medical Informatics, 195, 105755. https://doi.org/10.1016/j.ijmedinf.2024.105755

Assess the effectiveness of digital health interventions (DHIs) in reducing blood pressure (BP) among individuals with high blood pressure and identify the impact of age, sex, and phone-based delivery methods on BP. A systematic review and meta-analy... Read More about The digital prescription: A systematic review and meta-analysis of smartphone apps for blood pressure control..

Standards for Quality Improvement Registries on Abdominal Aortic Aneurysm Repair: A Delphi Consensus Report From VASCUNET and International Consortium of Vascular Registries. (2024)
Journal Article
Grima, M. J., Ancetti, S., Pherwani, A. D., Gonçalves, F. B., Budtz-Lilly, J., Behrendt, C.-A., …Mani, K. (in press). Standards for Quality Improvement Registries on Abdominal Aortic Aneurysm Repair: A Delphi Consensus Report From VASCUNET and International Consortium of Vascular Registries. European Journal of Vascular and Endovascular Surgery, 1-13. https://doi.org/10.1016/j.ejvs.2024.12.002

Outcome registries in vascular surgery are increasingly used to drive quality improvement by vascular societies. The VASCUNET collaboration, within the European Society for Vascular Surgery (ESVS), and the International Consortium of Vascular Registr... Read More about Standards for Quality Improvement Registries on Abdominal Aortic Aneurysm Repair: A Delphi Consensus Report From VASCUNET and International Consortium of Vascular Registries..

Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. (2024)
Journal Article
Maffulli, N., Christidis, G., Gougoulias, N., Christidis, P., Poku, D., Hassan, R., …Oliva, F. (in press). Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. British Medical Bulletin, 1-9. https://doi.org/10.1093/bmb/ldae019

The present prospective comparative study included patients with acute Achilles tendon rupture (ATR) who underwent percutaneous repair with one knot compared to percutaneous repair with two knots. All patients underwent the procedure under local anes... Read More about Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study..

Sex Differences in Patients Undergoing Left Main Stem Percutaneous Coronary Intervention for Stable Angina: Data From a National Registry. (2024)
Journal Article
Shamkhani, W., Zathar, Z., Khattak, S., Nolan, J., Chieffo, A., Kinnaird, T., & Mamas, M. A. (2024). Sex Differences in Patients Undergoing Left Main Stem Percutaneous Coronary Intervention for Stable Angina: Data From a National Registry. Journal of the American Heart Association, 13(22), Article e036569. https://doi.org/10.1161/JAHA.124.036569

Percutaneous coronary intervention (PCI) of the left main coronary artery (LMCA) for stable angina has steadily increased. Outcomes stratified by sex are inconclusive and limited. We assessed sex-based trends and differences in clinical outcomes amon... Read More about Sex Differences in Patients Undergoing Left Main Stem Percutaneous Coronary Intervention for Stable Angina: Data From a National Registry..

Quantifying Morphological Changes in Middle Trapezius With Ultrasonography and Histogram Matching for Participants With and Without Facioscapulohumeral Dystrophy (2024)
Journal Article
Philp, F., Meilak, E., Seyres, M., Willis, T., Winn, N., & Pandyan, A. (2024). Quantifying Morphological Changes in Middle Trapezius With Ultrasonography and Histogram Matching for Participants With and Without Facioscapulohumeral Dystrophy. Journal of Diagnostic Medical Sonography, https://doi.org/10.1177/87564793241293782

Objective: Echogenicity is a biomarker in facioscapulohumeral muscular dystrophy (FSHD). Currently, it is not possible to compare echogenicity values, derived using quantified muscle sonography capture, based on different equipment instrumentation se... Read More about Quantifying Morphological Changes in Middle Trapezius With Ultrasonography and Histogram Matching for Participants With and Without Facioscapulohumeral Dystrophy.

Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform (2024)
Presentation / Conference
Russell, M., Massey, J., Roddy, E., MacKenna, B., Bacon, S., Goldacre, B., …Galloway, J. (2024, November). Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform. Poster presented at Abstract Supplement ACR Convergence 2024, Washington DC

Background/Purpose: Data from before the COVID-19 pandemic had shown persistently poor care for people with gout in many countries worldwide. Whether this was further exacerbated by the pandemic is not fully understood. Our objective was to investiga... Read More about Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform.

Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review (2024)
Journal Article
Baroncini, A., Maffulli, N., Pilone, M., Pipino, G., Memminger, M. K., Pappalardo, G., & Migliorini, F. (2024). Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review. Journal of Clinical Medicine, 13(22), 1-27. https://doi.org/10.3390/jcm13226864

Background: Low back pain is common. For patients with mechanic or non-specific chronic LBP (cLBP), the current guidelines suggest conservative, nonpharmacologic treatment as a first-line treatment. Among the available strategies, physiotherapy repre... Read More about Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review.

Abstract 4143813: Secular Trends and Mortality Rates in Percutaneous Coronary Intervention in Non-ST Elevation Acute Coronary Syndrome: 15-Year Nationwide Survey (2024)
Journal Article
Abood, Z., Allaqaband, S., Sokhal, B., Tunink, K., Hommeida, M., Bajwa, T., & Jan, M. F. (2024). Abstract 4143813: Secular Trends and Mortality Rates in Percutaneous Coronary Intervention in Non-ST Elevation Acute Coronary Syndrome: 15-Year Nationwide Survey. Circulation, 150(Suppl_1), https://doi.org/10.1161/circ.150.suppl_1.4143813

Background: Non-ST elevation acute coronary syndrome (NSTE-ACS) is a leading cause of cardiovascular morbidity, with variable mortality across age groups. Older patients exhibit higher in-hospital mortality and often experience delayed percutaneous c... Read More about Abstract 4143813: Secular Trends and Mortality Rates in Percutaneous Coronary Intervention in Non-ST Elevation Acute Coronary Syndrome: 15-Year Nationwide Survey.

Abstract 4143796: Inpatient Mortality Trend in Obese Versus Non-Obese Patients With Acute Coronary Syndrome: “An Obesity Paradox” – 15-Year Nationwide Sample Analysis (2024)
Journal Article
Abood, Z., Bajwa, T., Sokhal, B., Tunink, K., Hommeida, M., Allaqaband, S., & Jan, M. F. (2024). Abstract 4143796: Inpatient Mortality Trend in Obese Versus Non-Obese Patients With Acute Coronary Syndrome: “An Obesity Paradox” – 15-Year Nationwide Sample Analysis. Circulation, 150(Suppl_1), https://doi.org/10.1161/circ.150.suppl_1.4143796

Background: Obesity is endemic in the United States. Previous studies have reported an obesity paradox in mortality associated with acute coronary syndrome (ACS). However, percutaneous coronary intervention (PCI) and inpatient mortality trends over a... Read More about Abstract 4143796: Inpatient Mortality Trend in Obese Versus Non-Obese Patients With Acute Coronary Syndrome: “An Obesity Paradox” – 15-Year Nationwide Sample Analysis.

Abstract 4143119: National Inpatient Mortality Trend of Mitral Valve Transcatheter Edge-to-Edge Repair in Patients With End-Stage Renal Disease on Dialysis (2024)
Journal Article
Abood, Z., Allaqaband, S., Galazka, P., Tunink, K., Sokhal, B., Hommeida, M., …Jan, M. F. (2024). Abstract 4143119: National Inpatient Mortality Trend of Mitral Valve Transcatheter Edge-to-Edge Repair in Patients With End-Stage Renal Disease on Dialysis. Circulation, 150(Suppl_1), https://doi.org/10.1161/circ.150.suppl_1.4143119

Background: Mitral valve transcatheter edge-to-edge repair (M-TEER) is performed for high-risk patients with severe mitral regurgitation and multiple comorbidities. End-stage renal disease (ESRD) is one poor prognostic factor in M-TEER. However, real... Read More about Abstract 4143119: National Inpatient Mortality Trend of Mitral Valve Transcatheter Edge-to-Edge Repair in Patients With End-Stage Renal Disease on Dialysis.

Abstract 4134687: Takotsubo Cardiomyopathy Complicating Stroke (2024)
Journal Article
Jang, S. H., Sposato, L., Choi, Y.-H., Geressu, A., Mamas, M., & Bagur, R. (2024). Abstract 4134687: Takotsubo Cardiomyopathy Complicating Stroke. Circulation, 150(Suppl_1), Article A4134687. https://doi.org/10.1161/circ.150.suppl_1.4134687

Background: There have been studies suggesting Takotsubo cardiomyopathy (TCM) as a potential complication following cerebrovascular accident (CVA), but the association, contributing factors, and prognosis significance have not been well-characterized... Read More about Abstract 4134687: Takotsubo Cardiomyopathy Complicating Stroke.