Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction. (2024)
Journal Article
Matetic, A., Kyriacou, T., & Mamas, M. A. (2024). Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction. International Journal of Cardiology, 411, 1-9. https://doi.org/10.1016/j.ijcard.2024.132272

Machine learning clustering of patients with ST-elevation acute myocardial infarction (STEMI) may provide important insights into their risk profile, management and prognosis. All adult discharges for STEMI in the National Inpatient Sample (October 2... Read More about Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction..

Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. (2024)
Journal Article
Yang, M.-L., Hu, C.-Y., Lee, Y.-C., Chang, C.-C., Chen, Y.-C., Lee, P.-R., …Wu, P. (in press). Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. Stem Cells Translational Medicine, Article szae039. https://doi.org/10.1093/stcltm/szae039

Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains a major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can... Read More about Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy..

GPs’ views of prescribing beta- blockers for people with anxiety disorders: a qualitative study (2024)
Journal Article
Archer, C., Kessler, D., Wiles, N., Chew-Graham, C. A., & Turner, K. (2024). GPs’ views of prescribing beta- blockers for people with anxiety disorders: a qualitative study. British Journal of General Practice (BJGP), Article BJGP.2024.0091. https://doi.org/10.3399/BJGP.2024.0091

Between 2003-2018, incident prescriptions of beta-blockers for anxiety increased substantially, particularly in young adults. NICE guidance for anxiety does not recommend beta-blockers, probably due to a lack of evidence to support such use. Recent r... Read More about GPs’ views of prescribing beta- blockers for people with anxiety disorders: a qualitative study.

Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. (2024)
Journal Article
Ebrahim, N., Al Saihati, H. A., Alali, Z., Aleniz, F. Q., Mahmoud, S. Y. M., Badr, O. A., …Alsabeelah, N. F. (2024). Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. Biomedicine and Pharmacotherapy, 176, Article 116836. https://doi.org/10.1016/j.biopha.2024.116836

Alzheimer's disease (AD) is a devastating neurological condition characterized by cognitive decline, motor coordination impairment, and amyloid plaque accumulation. The underlying molecular mechanisms involve oxidative stress, inflammation, and neuro... Read More about Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway..

Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study. (2024)
Journal Article
Ghosal, S., Heron, N., Mason, K., Bailey, J., & Jordan, K. (2024). Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study. British Journal of General Practice (BJGP), BJGP.2023.0684. https://doi.org/10.3399/bjgp.2023.0684

Orlistat is recommended as an adjunct to diet and exercise for weight loss in type 2 diabetes mellitus (T2DM). The aims were to explore (i) associations between patient characteristics and orlistat prescribing and to determine (ii) associations of or... Read More about Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study..

Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis (2024)
Thesis
Hay, C. A. (2024). Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775300

Background: Axial spondyloarthritis (axSpA) causes inflammation of the pelvis and spine, resulting in chronic pain, impaired range of movement, fatigue and physical disability. Diagnosis remains challenging and is frequently delayed, resulting in poo... Read More about Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis.

Complex, high-risk but Indicated Percutaneous Coronary Interventions (CHiP) types, trends, and clinical outcomes (2024)
Thesis
Al-Shamkhani, W. S. J. (2024). Complex, high-risk but Indicated Percutaneous Coronary Interventions (CHiP) types, trends, and clinical outcomes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775413

Coronary artery disease ( CAD) remains the leading cause of death worldwide. Medical therapy and lifestyle modifications are the first line of therapy to minimise symptoms and retard disease progression. An Invasive therapy in the form of percutaneou... Read More about Complex, high-risk but Indicated Percutaneous Coronary Interventions (CHiP) types, trends, and clinical outcomes.

How common are side effects of treatment to prevent gout flares when starting allopurinol? (2024)
Journal Article
Saul, H., Deeney, B., Swaithes, L., & Roddy, E. (in press). How common are side effects of treatment to prevent gout flares when starting allopurinol?. BMJ, 384, Article q514. https://doi.org/10.1136/bmj.q514

The studyRoddy E, Bajpai R, Forrester H, et al. Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. 2023;82:1618-25.To re... Read More about How common are side effects of treatment to prevent gout flares when starting allopurinol?.

Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study. (2024)
Journal Article
Ali, A. M. S., Gul, W., Sen, J., Hewitt, S.-J., Olubajo, F., & McMahon, C. (in press). Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study. Clinical Neurology and Neurosurgery, 239, Article 108215. https://doi.org/10.1016/j.clineuro.2024.108215

Assessment of the pupillary light reflex (PLR) is key in intensive care monitoring of neurosurgical patients, particularly for monitoring intracranial pressure (ICP). Quantitative pupillometry using a handheld pupillometer is a reliable method for PL... Read More about Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study..

Registry Capture of Implantable Vascular Devices to drive patient safety. (2024)
Journal Article
Boyle, J. R., Pherwani, A. D., & Goodney, P. P. (in press). Registry Capture of Implantable Vascular Devices to drive patient safety. European Journal of Vascular and Endovascular Surgery, S1078-5884(24)00201-6. https://doi.org/10.1016/j.ejvs.2024.02.041

How do medical schools influence their students’ career choices? A realist evaluation (2024)
Journal Article
Thomas, A., Kinston, R., Yardley, S., McKinley, R. K., & Lefroy, J. (2024). How do medical schools influence their students’ career choices? A realist evaluation. Medical Education Online, 29(1), https://doi.org/10.1080/10872981.2024.2320459

Introduction
The career choices of medical graduates vary widely between medical schools in the UK and elsewhere and are generally not well matched with societal needs. Research has found that experiences in medical school including formal, informal... Read More about How do medical schools influence their students’ career choices? A realist evaluation.

The invasive investigation of INOCA in the coronary catheterization lab (2024)
Journal Article
Burgess, S. N., & Mamas, M. A. (2024). The invasive investigation of INOCA in the coronary catheterization lab. American Heart Journal Plus: Cardiology Research and Practice, 38, Article 100365. https://doi.org/10.1016/j.ahjo.2024.100365

Over half of all patients with angina have no angiographically demonstratable obstructive coronary disease, with a significant proportion of these patients having undiagnosed microvascular dysfunction and/or vasospastic angina. In chronic coronary sy... Read More about The invasive investigation of INOCA in the coronary catheterization lab.

Clinical effectiveness of pharmacological and non-pharmacological treatments for the management of anxiety in community dwelling people living with dementia: A systematic review and meta-analysis (2023)
Journal Article
Nimmons, D., Aker, N., Burnand, A., Jordan, K. P., Cooper, C., Davies, N., …Walters, K. (2023). Clinical effectiveness of pharmacological and non-pharmacological treatments for the management of anxiety in community dwelling people living with dementia: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 157, 105507. https://doi.org/10.1016/j.neubiorev.2023.105507

Musculotendinous ruptures of the achilles tendon had greater heel-rise height index compared with mid-substance rupture with non-operative management: a retrospective cohort study (2023)
Journal Article
Carmont, M. R., Gunnarsson, B., Brorsson, A., & Nilsson-Helander, K. (2023). Musculotendinous ruptures of the achilles tendon had greater heel-rise height index compared with mid-substance rupture with non-operative management: a retrospective cohort study. Journal of ISAKOS, https://doi.org/10.1016/j.jisako.2023.12.006

Introduction
Achilles Tendon Ruptures (ATR) may occur at varying locations with ruptures at the mid-substance (MS) of the tendon most common, followed tears at the musculotendinous (MT) junction. There is scant li... Read More about Musculotendinous ruptures of the achilles tendon had greater heel-rise height index compared with mid-substance rupture with non-operative management: a retrospective cohort study.

Using video-based examiner score comparison and adjustment (VESCA) to compare the influence of examiners at different sites in a distributed objective structured clinical exam (OSCE) (2023)
Journal Article
Yeates, P., Maluf, A., Cope, N., McCray, G., McBain, S., Beardow, D., …McKinley, R. B. (2023). Using video-based examiner score comparison and adjustment (VESCA) to compare the influence of examiners at different sites in a distributed objective structured clinical exam (OSCE). BMC Medical Education, 23(1), Article 803. https://doi.org/10.1186/s12909-023-04774-4

Purpose: Ensuring equivalence of examiners’ judgements within distributed objective structured clinical exams (OSCEs) is key to both fairness and validity but is hampered by lack of cross-over in the performances which different groups of examiners o... Read More about Using video-based examiner score comparison and adjustment (VESCA) to compare the influence of examiners at different sites in a distributed objective structured clinical exam (OSCE).

Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study (2023)
Journal Article
Bishop, S., Narayanasamy, M. J., Paskins, Z., Corp, N., Bastounis, A., Griffin, J., …Sahota, O. (2023). Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study. BMC Musculoskeletal Disorders, 24(1), Article 770. https://doi.org/10.1186/s12891-023-06865-1

Background: Bisphosphonate medications, including alendronate, ibandronate and risedronate administered orally and zoledronate, administered intravenously, are commonly prescribed for the treatment of osteoporosis based on evidence that, correctly ta... Read More about Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study.

Complex high‐risk percutaneous coronary intervention types, trends, and outcomes according to vascular access site (2023)
Journal Article
Shamkhani, W., Moledina, S., Rashid, M., & Mamas, M. A. (in press). Complex high‐risk percutaneous coronary intervention types, trends, and outcomes according to vascular access site. Catheterization and Cardiovascular Interventions, 102(5), 803-813. https://doi.org/10.1002/ccd.30846

Background
Radial access is associated with improved outcomes following percutaneous coronary intervention (PCI); however, its role in complex, high-risk percutaneous coronary intervention (CHiP) remains poorly studied.

Methods
We studied retros... Read More about Complex high‐risk percutaneous coronary intervention types, trends, and outcomes according to vascular access site.

Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation. (2023)
Journal Article
Nakafero, G., Card, T., Grainge, M. J., Williams, H. C., Taal, M. W., Aithal, G. P., …Abhishek, A. (2023). Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation. EClinicalMedicine, 64, Article 102213. https://doi.org/10.1016/j.eclinm.2023.102213

Background
Patients established on thiopurines (e.g., azathioprine) are recommended to undergo three-monthly blood tests for the early detection of blood, liver, or kidney toxicity. These side-effects are uncommon during long-term treatment. We deve... Read More about Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation..

Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm (2023)
Journal Article
Philp, F., Meilak, E., Willis, T., Winn, N., & Pandyan, A. (in press). Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm. Gait & Posture, 106, S163-S164. https://doi.org/10.1016/j.gaitpost.2023.07.197

Introduction
Facioscapulohumeral dystrophy (FSHD) can affect upper-limb function through muscle degeneration, fatty infiltration and oedema. Muscle echogenicity, measured using ultrasound, could be used as a bioma... Read More about Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm.

Substantially more children receiving antidepressants see a specialist than reported by Jack et al. (2023)
Journal Article
Taxiarchi, V. P., Chew-Graham, C. A., & Pierce, M. (in press). Substantially more children receiving antidepressants see a specialist than reported by Jack et al. BMC Medicine, 21(1), Article 345. https://doi.org/10.1186/s12916-023-03043-x

We would like to draw attention to evidence of substantial bias in the article published in this journal by Jack et al. (BMC Med 18:1-12, 2020). They provide an analysis of antidepressant prescribing to children and young people (CYP; ages 5 to 17) i... Read More about Substantially more children receiving antidepressants see a specialist than reported by Jack et al..