An investigation into the role of protein phosphatase 4 in breast cancer (2018)
Thesis
Mohammed, H. N. (2018). An investigation into the role of protein phosphatase 4 in breast cancer. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412025

Breast cancer is the most common malignant tumour among females world-wide. The complexity of the pathogenesis of the disease and its heterogeneous clinical presentation, with an increasing incidence of the development of chemotherapeutic resistant c... Read More about An investigation into the role of protein phosphatase 4 in breast cancer.

Digital drug screening to detect falsified, expired andrecalled medicines (2018)
Thesis
Naughton, B. D. (2018). Digital drug screening to detect falsified, expired andrecalled medicines. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411443

Falsified medicines are a global health and pharmaceutical sector issue which affect supply chains in low, middle and high-income countries. There are many methods to identify substandard and falsified medicines. However, the European Union has intro... Read More about Digital drug screening to detect falsified, expired andrecalled medicines.

Validating models of injury risk prediction in football players (2018)
Thesis
Philp, F. D. (2018). Validating models of injury risk prediction in football players. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411140

Association football (soccer) is a popular sport and there is a high risk of injury for participants. Within the context of professional clubs, the risk of injury is also associated with the risk of financial costs. Therefore, injury reduction proces... Read More about Validating models of injury risk prediction in football players.

Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery (2018)
Thesis
Narayanasamy, K. K. (2018). Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411161

With the advent of powerful gene editing tools such as CRISPR/Cas9, advances in gene therapy have gained a second wind. Despite this, disease therapy still has not progressed beyond clinical trials due to limitations in current delivery methods. The... Read More about Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery.

Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis (2018)
Thesis
Musa, F. (2018). Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411162

In this project, we have designed, constructed, and validated a human tissue-engineered blood vessel construct (TEBV) to assess whether it could be used as a new model system in which to study thrombus formation under physiologically relevant conditi... Read More about Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis.

Silicon in health: A beneficial element in reducing the body burden of aluminium (2018)
Thesis
Jones, K. L. (2018). Silicon in health: A beneficial element in reducing the body burden of aluminium. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411347

The essentiality of silicon and the toxicity of aluminium within humans are both topics of much debate; the current conception is that silicon is essential in ameliorating aluminium toxicity, however, the evidence for this remains inconclusive.

T... Read More about Silicon in health: A beneficial element in reducing the body burden of aluminium.

Risk factors for the onset of musculoskeletal pain in children and adolescents (2018)
Thesis
Andreucci, A. (2018). Risk factors for the onset of musculoskeletal pain in children and adolescents. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411391

Background

Musculoskeletal pain is a major burden on society. Research in adults has identified risk factors associated with musculoskeletal pain onset, however at present evidence for risk factors in children and adolescents is limited.

Aims... Read More about Risk factors for the onset of musculoskeletal pain in children and adolescents.

Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation (2018)
Thesis
Ali, I. F. (2018). Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411432

The emergence and spread of resistance to antimalarial drugs has highlighted the demand to search for new drugs that target novel pathways in the human malaria parasite Plasmodium falciparum. This thesis explores the potential for targeting of the Pf... Read More about Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation.

Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise (2018)
Thesis
McRobert, C. (2018). Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411441

Background
Shoulder pain is a common, costly condition with variable prognosis. Commonly used treatments for shoulder pain in primary care include: (i) advice & analgesia, (ii) exercise and/or manual therapy, and (iii) corticosteroid injection. Curr... Read More about Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise.

Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills (2018)
Thesis
Lefroy, J. (2018). Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411453

Background
Consultation skills are the core competencies required at graduation of the doctor as a practitioner. Every medical school has its own system of teaching and assessing consultation skills. These are generally amalgams of previous curricu... Read More about Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills.

The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management (2018)
Thesis
Lindsay, C. (2018). The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411458

Introduction
Patients surviving a severe stroke are at risk of developing contractures. Evidence suggests that spasticity may be a cause of contractures, particularly in patients who have not recovered functional movement. The relationship and the t... Read More about The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management.

Multisite pain and falls in older people (2018)
Thesis
Welsh, V. K. (2018). Multisite pain and falls in older people. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410388

Falls are a common occurrence in older people and multisite pain has been identified as a potential falls risk factor in this age group. This thesis aims to describe the relationship between multisite pain and falls in community-dwelling older people... Read More about Multisite pain and falls in older people.

Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression (2018)
Thesis
Merkhan, M. M. (2018). Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410396

Human mesenchymal stem cells (hMSCs) have multiple potential roles in regenerative medicine. These roles revolve around the exploitation of their multipotent differentiation potential, their immunogenic privilege, or the broad range of molecules they... Read More about Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression.

Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy (2018)
Thesis
Abo Donia, M. N. A. (2018). Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410399

Ovarian cancer is a complex disease characterized by low incidence, accounting for about 4% of cancer diagnoses in women, but with rapid progression and higher mortality rate than any other gynecological malignancy. Approximately 70 % of the cases ar... Read More about Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy.

The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair (2018)
Thesis
Bhattacharjee, A. (2018). The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410400

Aims
To evaluate the in vitro potential of umbilical cord(UC)-derived cells as an allogeneic cell source that could be used ‘off-the-shelf’ in orthopaedics for bone and cartilage regeneration. The study also assesses the in-vivo efficacy of cell the... Read More about The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair.

Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology (2018)
Thesis
Ahmed, M. A. (2018). Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410299

Oxygen is an important molecule in life and is essential for a broad spectrum of physiological reactions that include, but are not restricted to, cell metabolism, respiration and growth. Under physiological conditions, oxygen levels vary from one tis... Read More about Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology.

Development of a clinical care pathway for anaemic patients (2018)
Thesis
Ballal, M. (2018). Development of a clinical care pathway for anaemic patients. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418240

Improving cancer survival in the UK is one of the leading items on the agenda of the government. Survival from gastrointestinal cancer is yet to come into line with Europe. In 2000 the department of health (DoH) introduced guidelines for referral of... Read More about Development of a clinical care pathway for anaemic patients.

The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques. (2017)
Thesis
Mirza, A. (2017). The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/409155

The aim of this thesis was to optimise a method for the unequivocal identification of aluminium (Al) in human brain tissue. The second aim was to devise a protocol that was simple to implement and as such could be carried out without the need for sop... Read More about The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques..

GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey (2017)
Journal Article
Roddy, E., Cottrell, E., Foster, N. E., Porcheret, M., & Rathod, T. (2017). GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey. BMJ Open, 7(6), e014999 - ?. https://doi.org/10.1136/bmjopen-2016-014999

OBJECTIVES:
The aim of this study was to investigate general practitioners' (GPs) attitudes, beliefs and behaviours regarding the use of exercise for patients with chronic knee pain (CKP) attributable to osteoarthritis.

SETTING: Primary care GPs... Read More about GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey.

Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis (2017)
Journal Article
Nicolson, P. J. A., Bennell, K. L., Dobson, F. L., Van Ginckel, A., Holden, M. A., & Hinman, R. S. (2017). Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis. British Journal of Sports Medicine, 51(10), 791-799. https://doi.org/10.1136/bjsports-2016-096458

Objective To evaluate whether interventions aimed at increasing adherence to therapeutic exercise increase adherence greater than a contextually equivalent control among older adults with chronic low back pain and/or hip/knee osteoarthritis.

Desig... Read More about Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis.