Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis (2022)
Journal Article
Gilchrist, F., Aspey, M., Bowler, R., Brodlie, M., Desai, S., Harris, C., …Carroll, W. D. (2022). Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis. BMJ Paediatrics Open, e001722 - e001722. https://doi.org/10.1136/bmjpo-2022-001722

Background Protracted bacterial bronchitis (PBB) is an endobronchial infection and a the most common cause of chronic wet cough in young children. It is treated with antibiotics, which can only be targeted if the causative organism is known. As most... Read More about Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis.

COVID‐19 infection and nocardiosis causing the death of an adolescent with cystic fibrosis (2022)
Journal Article
Driscoll, S., Carroll, W. D., Nichani, S., Gilchrist, F. J., Fishwick, R., & Bakewell, K. (2022). COVID‐19 infection and nocardiosis causing the death of an adolescent with cystic fibrosis. Pediatric Pulmonology, 57(7), 1823-1825. https://doi.org/10.1002/ppul.25954

Letter

Why are children with asthma bullied? A risk factor analysis. (2021)
Journal Article
Gilchrist. (2021). Why are children with asthma bullied? A risk factor analysis. Archives of Disease in Childhood, https://doi.org/10.1136/archdischild-2021-321641

The links between bullying and asthma have not been explored in children. We wanted to determine the child/parent factors and attitudes associated with asthma-related bullying. Individual child/parent responses of children with asthma (N=943) from th... Read More about Why are children with asthma bullied? A risk factor analysis..

Managing chronic wet cough in children: another piece of the puzzle. (2021)
Journal Article
Gilchrist. (2021). Managing chronic wet cough in children: another piece of the puzzle. Lancet Respiratory Medicine, 1078 - 1079. https://doi.org/10.1016/S2213-2600%2821%2900159-4

Chronic wet cough is the hallmark of chronic obstructive pulmonary disease in older people and bronchiectasis in adults and older children. In young children, the commonest cause of chronic wet cough is protracted bacterial bronchitis (PBB) but there... Read More about Managing chronic wet cough in children: another piece of the puzzle..

Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis. (2021)
Journal Article
Horsley, A. R., Belcher, J., Bayfield, K., Bianco, B., Cunningham, S., Fullwood, C., …Gilchrist, F. J. (2021). Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis. Thorax, 77(4), https://doi.org/10.1136/thoraxjnl-2021-216928

BACKGROUND: Lung clearance index (LCI) is a valuable research tool in cystic fibrosis (CF) but clinical application has been limited by technical challenges and uncertainty about how to interpret longitudinal change. In order to help inform clinical... Read More about Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis..

Is there an association between having asthma and being bullied? (2020)
Journal Article
Gilchrist. (2020). Is there an association between having asthma and being bullied?. Archives of Disease in Childhood, 903 - 905. https://doi.org/10.1136/archdischild-2020-319354

Child poverty, food insecurity, and respiratory health during the COVID-19 pandemic. (2020)
Journal Article
Gilchrist. (2020). Child poverty, food insecurity, and respiratory health during the COVID-19 pandemic. Lancet Respiratory Medicine, 762 - 763. https://doi.org/10.1016/S2213-2600%2820%2930280-0

'No abstract'

Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in (2020)
Journal Article
Gilchrist. (2020). Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in. PloS one, https://doi.org/10.1371/journal.pone.0229300

INTRODUCTION: Lung clearance index (LCI) is a sensitive measure of early lung disease, but adoption into clinical practice has been slow. Challenges include the time taken to perform each test. We recently described a closed-circuit inert gas wash-in... Read More about Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in.

Less sun, more cough: Annual hours of sunshine are inversely associated with hospital admissions for children with lower respiratory tract infection (2019)
Presentation / Conference
Gilchrist. (2019, September). Less sun, more cough: Annual hours of sunshine are inversely associated with hospital admissions for children with lower respiratory tract infection. Presented at ERS International Congress 2019, IFEMA, Madrid

Background: Vitamin D deficiency affects immune function increasing susceptibility to respiratory tract infections (RTI). Randomised controlled trials show vitamin D supplementation protects against acute RTIs. Most vitamin D (>90%) is acquired from... Read More about Less sun, more cough: Annual hours of sunshine are inversely associated with hospital admissions for children with lower respiratory tract infection.

Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis (2019)
Presentation / Conference
Grose-Hodge, E., Carroll, W., Rainford, N., Gamble, C., & Gilchrist, F. (2019, September). Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis. Presented at ERS International Congress 2019, Madrid, Spain

Background: Protracted Bacterial Bronchitis (PBB) is a leading cause of chronic wet cough in children. Antibiotic response is a diagnostic criterion but there is little evidence to inform duration of treatment. Relapse is common and those who relapse... Read More about Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis.

Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres (2019)
Journal Article
Ditchfield, N., Carroll, W., & Gilchrist, F. (2019). Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.09.004

Highlights

IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA.

The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity.

More than one third of UK CF... Read More about Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres.

UNWARRANTED USE OF NEPHROTOXIC ANTIBIOTICS IN CHILDREN WITH CYSTIC FIBROSIS (2018)
Presentation / Conference
Gilchrist. (2018, December). UNWARRANTED USE OF NEPHROTOXIC ANTIBIOTICS IN CHILDREN WITH CYSTIC FIBROSIS. Presented at British Thoracic Society Winter Meeting 2018, QEII Centre, Broad Sanctuary, Westminster, London, England

Introduction As life expectancy of individuals with cystic fibrosis (CF) continues to increase, complications resulting from lifetime drug exposures and CF comorbidities are becoming more prevalent. An example of this is chronic kidney disease (CKD).... Read More about UNWARRANTED USE OF NEPHROTOXIC ANTIBIOTICS IN CHILDREN WITH CYSTIC FIBROSIS.

Identifying Asthmatic Children using Tidal Breathing Parameters Measured by Structured Light Plethysmography (SLP) (2018)
Presentation / Conference
Gilchrist. (2018, September). Identifying Asthmatic Children using Tidal Breathing Parameters Measured by Structured Light Plethysmography (SLP). Presented at ERS International Congress 2018, Paris, France

Introduction: We have previously shown that several tidal breathing parameters measured using SLP varied between asthmatic children and healthy (Hmeidi et al., 2017). However, we did not test the classification power of a model which incorporates the... Read More about Identifying Asthmatic Children using Tidal Breathing Parameters Measured by Structured Light Plethysmography (SLP).

Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children (2018)
Journal Article
Gilchrist. (2018). Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children. Physiological Reports, e13752. https://doi.org/10.14814/phy2.13752

Measurement of lung function can be difficult in young children. Structured light plethysmography (SLP) is a novel, noncontact method of measuring tidal breathing that monitors displacement of the thoraco-abdominal wall. SLP was used to compare breat... Read More about Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children.

The British Lung Foundation asthma management programme - improving asthma control in adults (2017)
Presentation / Conference
Gilchrist. (2017, September). The British Lung Foundation asthma management programme - improving asthma control in adults. Presented at ERS International Congress 2017, Milan, Italy

Background: The 10-year Finland asthma programme showed that educating healthcare workers, patients and families reduces hospital admissions and asthma-related deaths (1).

Aim: The Department of Health and the Scottish Government funded a 2-year p... Read More about The British Lung Foundation asthma management programme - improving asthma control in adults.

Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions (2017)
Journal Article
Gilchrist. (2017). Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions. Clinical and Experimental Allergy, 838-840. https://doi.org/10.1111/cea.12946

During childhood, exacerbation of asthma is the most common medical reason for admission to hospital in the UK. Each year 44,000 children are admitted to hospital in the UK with 40-50 children dying as a result of asthma [1]. Weather patterns and sea... Read More about Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions.

Modeling Nutritional Outcomes for Infants Diagnosed With Cystic Fibrosis by Newborn Screening (Meeting Abstract) (2016)
Journal Article
Patterson, K., Kyriacou, T., Desai, M., Carroll, W., & Gilchrist, F. (2016). Modeling Nutritional Outcomes for Infants Diagnosed With Cystic Fibrosis by Newborn Screening (Meeting Abstract). Thorax, 71(3), A131 -A132. https://doi.org/10.1136/thoraxjnl-2016-209333.232

Meeting abstract published in supplement of the Thorax journal, December 2016.

Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract) (2016)
Journal Article
Gilchrist, & Roffe. (2016). Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract). European Respiratory Journal, https://doi.org/10.1183/13993003.congress-2016.PA4156

Background
The extent of respiratory compromise following a stroke depends on any pre-existing respiratory illness and the aetiology, location and extent of the lesion. Acquired respiratory infection in subsequent days may alter respiratory function... Read More about Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract).

REPEATABILITY OF LUNG CLEARANCE INDEX (LCI) IN CLINICALLY STABLE PATIENTS WITH MILD CYSTIC FIBROSIS (CF) (2016)
Journal Article
Gilchrist. (2016). REPEATABILITY OF LUNG CLEARANCE INDEX (LCI) IN CLINICALLY STABLE PATIENTS WITH MILD CYSTIC FIBROSIS (CF). Pediatric Pulmonology, 348 - 348

Assessing chronic cough in children (2016)
Journal Article
Gilchrist. (2016). Assessing chronic cough in children. Paediatrics and Child Health, 273-275. https://doi.org/10.1016/j.paed.2016.03.002

Cough is a protective physiological reflex that aids the clearance of airway secretions and aspirated material. As such, it is normal to cough. Coughing becomes abnormal when the frequency or severity impacts on the child's ability to eat, sleep, pla... Read More about Assessing chronic cough in children.