Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study (2022)
Journal Article
Abas, S., Kuiper, J. H., Roberts, S., McCarthy, H., Williams, M., Bing, A., …Makwana, N. (2022). Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study. Cells, 11(4), Article 629. https://doi.org/10.3390/cells11040629

Osteochondral defects of the ankle (OCD) are being increasingly identified as a clinically significant consequence of injury to the ankle, with the potential to lead to osteoarthritis if left untreated. The aim of this retrospective cohort study was... Read More about Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study.

Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model (2021)
Journal Article
Perry, J., Roelofs, A. J., Mennan, C., McCarthy, H. S., Richmond, A., Clark, S. M., …Roberts, S. (2021). Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. Cells, 1-16. https://doi.org/10.3390/cells10081999

Human umbilical cord (hUC)- or bone marrow (hBM)-derived mesenchymal stromal cells (MSCs) were evaluated as an allogeneic source of cells for cartilage repair. We aimed to determine if they could enhance healing of chondral defects with or without th... Read More about Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model.

Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases (2019)
Journal Article
Wang, J., Wright, K., Perry, J., Tins, B., Hopkins, T., Hulme, C., …Richardson, J. (2019). Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases. Cell Transplantation, 28(7), 924 - 931. https://doi.org/10.1177/0963689719845328

Autologous chondrocyte implantation (ACI) has been used to treat cartilage defects for >20 years, with promising clinical outcomes. Here, we report two first-in-man cases (patient A and B) treated with combined autologous chondrocyte and bone marrow... Read More about Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases.

Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. (2016)
Journal Article
Bhattacharjee, A., McCarthy, H. S., Tins, B., Roberts, S., Kuiper, J. H., Harrison, P. E., & Richardson, J. B. (2016). Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. American Journal of Sports Medicine, 44(5), 1249 - 1259. https://doi.org/10.1177/0363546516631739

BACKGROUND: Structural and functional outcome of bone graft with first- or second-generation autologous chondrocyte implantation (ACI) in treating cartilage and subchondral bone defect has not been reported previously. PURPOSE: To evaluate the outcom... Read More about Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee..

Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues (2013)
Journal Article
Hanifi, A., McCarthy, H., Roberts, S., & Pleshko, N. (2013). Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues. PloS one, 8(5), Article e64822. https://doi.org/10.1371/journal.pone.0064822

Hyaline cartilage and mechanically inferior fibrocartilage consisting of mixed collagen types are frequently found together in repairing articular cartilage. The present study seeks to develop methodology to identify collagen type and other tissue co... Read More about Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues.