Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis (2023)
Journal Article
Istanbuly, O., Belcher, J., Tabinor, M., Solis-Trapala, I., Lambie, M., & Davies, S. J. (in press). Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis. BMC Nephrology, 24(1), Article 312. https://doi.org/10.1186/s12882-023-03370-4

Background: Systemic inflammation, measured as circulating Interleukin-6 (IL-6) levels, is associated with cardiovascular and all-cause mortality in chronic kidney disease. However, this has not been convincingly demonstrated in a systematic review o... Read More about Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis.

Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR (2022)
Journal Article
Lindley, E., Keane, D., Belcher, J., Fernandes Da Silva Jeffcoat, N., Davies, S., & trial investigators, B. (2022). Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR. Physiological Measurement, 43(8), Article 08NT01. https://doi.org/10.1088/1361-6579/ac80e8

OBJECTIVE: With growing recognition of the benefits of preserving residual kidney function (RKF) and use of incremental treatment regimes, the incentive to measure residual clearance in haemodialysis patients is increasing. Interdialytic urine collec... Read More about Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR.

Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis. (2021)
Journal Article
Horsley, A. R., Belcher, J., Bayfield, K., Bianco, B., Cunningham, S., Fullwood, C., …Gilchrist, F. J. (2021). Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis. Thorax, 77(4), https://doi.org/10.1136/thoraxjnl-2021-216928

BACKGROUND: Lung clearance index (LCI) is a valuable research tool in cystic fibrosis (CF) but clinical application has been limited by technical challenges and uncertainty about how to interpret longitudinal change. In order to help inform clinical... Read More about Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis..

Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure (2021)
Journal Article
Lagan LEKARZ, J., Schelbert, E. B., Naish, J. H., Vestbo, J., Fortune, C., Bradley, J., …Miller, C. A. (2021). Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure. JACC: Cardiovascular Imaging, 14(10), 1963-1973. https://doi.org/10.1016/j.jcmg.2021.03.026

OBJECTIVES: The purposes of this study were to determine why chronic obstructive pulmonary disease (COPD) is associated with heart failure (HF). Specific objectives included whether COPD is associated with myocardial fibrosis, whether myocardial fibr... Read More about Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure.

The Effect of Pain Conditioning on Experimentally Evoked Cough: Evidence of Impaired Endogenous Inhibitory Control Mechanisms in Refractory Chronic Cough (2020)
Journal Article
Hilton, E., Satia, I., Holt, K., Woodcock, A. A., Belcher, J., & Smith, J. A. (2020). The Effect of Pain Conditioning on Experimentally Evoked Cough: Evidence of Impaired Endogenous Inhibitory Control Mechanisms in Refractory Chronic Cough. European Respiratory Journal, 56(6), 2001387 - 2001387. https://doi.org/10.1183/13993003.01387-2020

Background: The pathophysiology of refractory chronic cough (RCC) is unclear. We hypothesised that endogenous inhibitory control mechanisms, such as those activated by painful stimuli (conditioned pain modulation (CPM)), may be capable of inhibiting... Read More about The Effect of Pain Conditioning on Experimentally Evoked Cough: Evidence of Impaired Endogenous Inhibitory Control Mechanisms in Refractory Chronic Cough.

Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study (2019)
Journal Article
Muller, S., Whittle, R., Hider, S. L., Belcher, J., Helliwell, T., Morton, C., …Mallen, C. D. (2020). Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study. Rheumatology, 59(8), 1906-1915. https://doi.org/10.1093/rheumatology/kez533

Objectives. To investigate potential subgroups of primary care diagnosed patients with polymyalgia rheumatica (PMR) based on self-reported pain and stiffness severity over time.

Methods. 652 people with an incident PMR diagnosis were recruited fro... Read More about Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study.

Gender-specific risk factors for gout: a systematic review of cohort studies (2019)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Hay, C. A., Mallen, C. D., & Roddy, E. (2019). Gender-specific risk factors for gout: a systematic review of cohort studies. Advances in Rheumatology, 59, Article 24. https://doi.org/10.1186/s42358-019-0067-7

BACKGROUND:
Though gout is more prevalent in men than women, it remains unclear whether gender influences risk factors for incident gout. We aimed to systematically review all cohort studies examining risk factors for the development of gout by gend... Read More about Gender-specific risk factors for gout: a systematic review of cohort studies.

Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death (2019)
Journal Article
Lambie, M., Teece, L., Johnson, D. W., Petrie, M., Mactier, R., Solis-Trapala, I., …Davies, S. J. (2019). Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death. Nephrology Dialysis Transplantation, 1585-1591. https://doi.org/10.1093/ndt/gfz034

Background
Risk of Encapsulating Peritoneal Sclerosis (EPS) is strongly associated with the duration of peritoneal dialysis (PD), such that patients who have been on PD for some time may consider elective transfer to haemodialysis to mitigate risk o... Read More about Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death.

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study (2018)
Journal Article
Mallen, Roddy, Belcher, Clarson, & Muller. (2018). Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study. Arthritis Research and Therapy, 20, Article 243. https://doi.org/10.1186/s13075-018-1746-1

BACKGROUND: An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lowering therapy (ULT) on developm... Read More about Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study.

Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., …Mallen, C. D. (2018). Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial. Arthritis Care and Research, 70(12), 1787-1794. https://doi.org/10.1002/acr.23568

OBJECTIVE: To investigate the cost-effectiveness (cost-utility) of introducing general practitioner screening for anxiety and depression in patients consulting with osteoarthritis (OA). METHODS: A cluster-randomised trial-based economic evaluation to... Read More about Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial.

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article
Roddy, Mallen, Clarson, Belcher, & Hider. (2017). Factors Influencing Allopurinol Initiation in Primary Care. Annals of Family Medicine, 15(6), 557 - 560. https://doi.org/10.1370/afm.213

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

Public priorities for osteoporosis and fracture research: results from a general population survey (2017)
Journal Article
Paskins, Z., Jinks, C., Mahmood, W., Jayakumar, P., Sangan, C. B., Belcher, J., & Gwilym, S. (2017). Public priorities for osteoporosis and fracture research: results from a general population survey. Archives of Osteoporosis, 12(45), https://doi.org/10.1007/s11657-017-0340-5

This is the first national study of public and patient research priorities in osteoporosis and fracture. We have identified new research areas of importance to members of the public, particularly ‘access to information from health professionals’. The... Read More about Public priorities for osteoporosis and fracture research: results from a general population survey.

Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain (2016)
Journal Article
Ukachukwu, V., Duncan, R., Belcher, J., Marshall, M., Stefanik, J., Crossley, K., …Peat, G. (2017). Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain. Arthritis Care and Research, 69(7), 943-951. https://doi.org/10.1002/acr.23110

Objective
To determine the comparative prevalence, associations with selected patient characteristics, and clinical outcomes of medial and lateral compartment patellofemoral (PF) joint osteoarthritis (OA).

Methods
Information was collected by qu... Read More about Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain.

Virtual imaging for patient information on radiotherapy planning and delivery (2016)
Presentation / Conference
Sule-Suso, J., Finney, S., Bisson, J., Hammersley, S., Jassal, S., Knight, C., …Moloney, A. (2016, April). Virtual imaging for patient information on radiotherapy planning and delivery. Poster presented at ESTRO 35, Turin, Italy

Purpose or Objective: To assess whether both patients and
their relatives would welcome further information on a oneto-one basis on RT planning and delivery using the virtual
reality (VR) system VERT.

One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. (2015)
Journal Article
Rzewuska, M., Mallen, C. D., Strauss, V. Y., Belcher, J., & Peat, G. (2015). One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. Journal of Psychosomatic Research, 79(3), 195 - 201. https://doi.org/10.1016/j.jpsychores.2015.05.016

OBJECTIVE: Distinguishing transient from persistent anxiety and depression symptoms in older people presenting to general practice with musculoskeletal pain is potentially important for effective management. This study sought to identify distinct pos... Read More about One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis..

The effectiveness of national guidance in changing analgesic prescribing in primary care from 2002 to 2009: an observational database study (2012)
Journal Article
Bedson, J., Belcher, J., Martino, O., Ndlovu, M., Rathod, T., Walters, K., …Jordan, K. (2013). The effectiveness of national guidance in changing analgesic prescribing in primary care from 2002 to 2009: an observational database study. European Journal of Pain, 17(3), 434 -443. https://doi.org/10.1002/j.1532-2149.2012.00189.x

BACKGROUND: Numerous national guidelines have been issued to assist general practitioners' safe analgesic prescribing. Their effectiveness is unclear. The objective of this study was to examine trends in general practitioners' prescribing behaviour i... Read More about The effectiveness of national guidance in changing analgesic prescribing in primary care from 2002 to 2009: an observational database study.