Recommendations for terminology and the identification of neuropathic pain in people with spine-related leg pain. Outcomes from the NeuPSIG working group (2023)
Journal Article
Schmid, A. B., Tampin, B., Baron, R., Finnerup, N. B., Hansson, P., Hietaharju, A., …Slater, H. (in press). Recommendations for terminology and the identification of neuropathic pain in people with spine-related leg pain. Outcomes from the NeuPSIG working group. PAIN, 164(8), 1693-1704. https://doi.org/10.1097/j.pain.0000000000002919

Pain radiating from the spine into the leg is commonly referred to as “sciatica,” “Sciatica” may include various conditions such as radicular pain or painful radiculopathy. It may be associated with significant consequences for the person living with... Read More about Recommendations for terminology and the identification of neuropathic pain in people with spine-related leg pain. Outcomes from the NeuPSIG working group.

Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica. (2019)
Journal Article
Hall, J. A., Konstantinou, K., Lewis, M., Oppong, R., Ogollah, R., & Jowett, S. (2019). Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica. Applied Health Economics and Health Policy, 17, 467-491. https://doi.org/10.1007/s40258-019-00471-w

BACKGROUND:
Low back pain (LBP) and sciatica place significant burden on individuals and healthcare systems, with societal costs alone likely to be in excess of £15 billion. Two recent systematic reviews for LBP and sciatica identified a shortage of... Read More about Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica..

Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis (2019)
Journal Article
Kigozi, J., Konstantinou, K., Ogollah, R., Dunn, K., Lewis, M., & Jowett, S. (2019). Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis. BMC Health Services Research, https://doi.org/10.1186/s12913-019-4257-0

Background
There is limited research on the economic burden of low back-related leg pain, including sciatica. The aim of this study was to describe healthcare resource utilisation and factors associated with cost and health outcomes in primary care... Read More about Factors associated with costs and health outcomes in patients with Back and leg pain in primary care: a prospective cohort analysis.

Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort (2019)
Journal Article
Hider, S. L., Konstantinou, K., Hay, E. M., Glossop, J., & Mattey, D. L. (2019). Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort. BMC Musculoskeletal Disorders, 20, Article 202. https://doi.org/10.1186/s12891-019-2604-2

Background
There is increasing interest in the role of pro-inflammatory cytokines in the pathogenesis of sciatica and whether these could be potential targets for treatment. We sought to investigate serum biomarker levels in patients with low back-r... Read More about Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort.

Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC) (2018)
Journal Article
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., …Wilkinson, C. (2018). Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC). Trials, 19, Article 408. https://doi.org/10.1186/s13063-018-2801-6

BACKGROUND: Adalimumab, a biological treatment targeting tumour necrosis factor a, might be useful in sciatica. This paper describes the challenges faced when developing a new treatment pathway for a randomised controlled trial of adalimumab for peop... Read More about Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).