Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device (2021)
Journal Article
Wragg, N. (2021). Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Molecular Therapy - Methods and Clinical Development, 551-566. https://doi.org/10.1016/j.omtm.2021.10.015

Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir... Read More about Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device.

The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures (2021)
Journal Article
Andersen, C., Wragg, N., Shariatzadeh, M., & Wilson, S. L. (2021). The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures. Current Osteoporosis Reports, 19, 1-14. https://doi.org/10.1007/s11914-020-00643-x

PURPOSE OF REVIEW: The treatment of non-union fractures represents a significant challenge for orthopaedic surgeons. In recent years, biologic agents have been investigated and utilised to support and improve bone healing. Among these agents, platele... Read More about The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures.

Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis. (2020)
Journal Article
Claire Doyle, E., Wragg, N., & Louise Wilson, S. (2020). Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy, 28, 3827–3842. https://doi.org/10.1007/s00167-020-05859-z

PURPOSE: This review aimed to evaluate the efficacy of intra-articular injections of bone marrow derived mesenchymal stem cells (BM-MSCs) for the treatment of knee osteoarthritis (KOA). METHODS: This narrative review evaluates recent English language... Read More about Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis..

Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. (2019)
Journal Article
Wragg, N. (2019). Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Molecular Neurobiology, 6156 - 6167. https://doi.org/10.1007/s12035-019-1500-y

Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a... Read More about Systematic Review of miRNA as Biomarkers in Alzheimer's Disease..

Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. (2019)
Journal Article
Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377, 153 - 159. https://doi.org/10.1007/s00441-019-03016-8

There is a current need for a therapy that can alleviate the social and economic burden that presents itself with debilitating and recurring musculoskeletal soft tissue injuries and disorders. Currently, several therapies are emerging and undergoing... Read More about Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing..

Development of tissue-engineered skeletal muscle manufacturing variables. (2019)
Journal Article
Wragg, N. (2019). Development of tissue-engineered skeletal muscle manufacturing variables. Biotechnology and Bioengineering, 2364 - 2376. https://doi.org/10.1002/bit.27074

Three-dimensional tissue-engineered structures enable more representative determination of novel drug or material effects on tissue than traditional monolayer cell cultures. This study sought to better understand how key manufacturing variables affec... Read More about Development of tissue-engineered skeletal muscle manufacturing variables..

The use of PRP injections in the management of knee osteoarthritis. (2019)
Journal Article
O’Connell, B., Wragg, N., & Louise Wilson, S. (2019). The use of PRP injections in the management of knee osteoarthritis. Cell and Tissue Research, 376, 143 - 152. https://doi.org/10.1007/s00441-019-02996-x

Osteoarthritis (OA) is a degenerative disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture that commonly affects the knee and/or hip joints. It is a major world public health problem a... Read More about The use of PRP injections in the management of knee osteoarthritis..