Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. (2022)
Journal Article
Sokhal, B., Matetić, A., Bharadwaj, A., Helliwell, T., Abhishek, A., Mallen, C., …Mamas, M. (2022). Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. American Journal of Cardiology, 12-19. https://doi.org/10.1016/j.amjcard.2022.03.034

This study analyzed the characteristics, management, and outcomes of patients with polymyalgia rheumatica (PMR) hospitalized with acute myocardial infarction (AMI), including sensitivity analysis for presence of giant cell arteritis (GCA). Using the... Read More about Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis..

Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis (2021)
Journal Article
Yahaya, I., Wright, T., Babatunde, O., Corp, N., Helliwell, T., Dikomitis, L., & Mallen, C. (2021). Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis. Rheumatology International, 41, 1221-1231. https://doi.org/10.1007/s00296-021-04838-y

Evidence from the Global Burden of Disease studies suggests that osteoarthritis (OA) is a significant cause of disability globally; however, it is less clear how much of this burden exists in low-income and lower middle-income countries. This study a... Read More about Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis.

Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy (2021)
Journal Article
Mamas, Clarson, Roddy, Mallen, & Helliwell. (2021). Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy. Mayo Clinic Proceedings, 388-399. https://doi.org/10.1016/j.mayocp.2020.04.044

Objectives: The present study sought to examine national-level differences in management strategies and outcomes in patients with autoimmune rheumatic disease (AIRD) with acute myocardial infarction (AMI) between 2004 and 2014.
Methods: All AMI hos... Read More about Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy.

Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2021). Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study. Arthritis Care and Research, 73(12), 1853-1857. https://doi.org/10.1002/acr.24403

OBJECTIVE: To determine whether a diagnosis of polymyalgia rheumatica (PMR) is associated with premature mortality. METHODS: We extracted anonymised electronic medical records of patients over the age of 40 years, who were eligible for linkage with t... Read More about Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study.

Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2020). Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study. Seminars in Arthritis and Rheumatism, 50(4), 663-672. https://doi.org/10.1016/j.semarthrit.2020.05.003

Objectives: To determine the burden of comorbidities, including glucocorticoid (GC) related adverse effects, in patients with polymyalgia rheumatica (PMR) before and after diagnosis.

Methods: We extracted anonymised electronic medical records of p... Read More about Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study.

THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA (2020)
Journal Article
Helliwell, T., Mallen, C. D., Scott, I. C., Bajpai, R., Muller, S., & Hider, S. L. (2020). THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA. Rheumatology, 59, 18-18. https://doi.org/10.1093/RHEUMATOLOGY/KEAA110.037

Background
Obesity predisposes to a pro-inflammatory state. Studies have reported worse clinical outcomes in patients with inflammatory arthritis who are obese. The relationship between obesity and outcomes in patients with polymyalgia rheumatica (P... Read More about THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA.

The relationship between obesity and outcomes in patients with polymyalgia rheumatica (2020)
Presentation / Conference
Scott, I. C., Bajpai, R., Mallen, C., Muller, S., Helliwell, T., & Hider, S. (2020, April). The relationship between obesity and outcomes in patients with polymyalgia rheumatica. Presented at British Society for Rheumatology Annual Conference 2020, Scottish Event Campus (SEC), Scotland, UK

Background
Obesity predisposes to a pro-inflammatory state. Studies have reported worse clinical outcomes in patients with inflammatory arthritis who are obese. The relationship between obesity and outcomes in patients with polymyalgia rheumatica (P... Read More about The relationship between obesity and outcomes in patients with polymyalgia rheumatica.

The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure (2020)
Journal Article
Shing Kwok, C., Zieroth, S., Van Spall, H. G. C., Helliwell, T., Clarson, L., Mohamed, M., …Mamas, M. A. (2020). The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure. International Journal of Cardiology, 184-190. https://doi.org/10.1016/j.ijcard.2019.09.064

Background:
Little is known about frailty amongst patients hospitalized with heart failure (HF) on a national level.

Methods:
We conducted a retrospective cohort study of patients admitted to hospital for HF in the United States. We examined how... Read More about The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure.

Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study (2019)
Journal Article
Muller, S., Whittle, R., Hider, S. L., Belcher, J., Helliwell, T., Morton, C., …Mallen, C. D. (2020). Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study. Rheumatology, 59(8), 1906-1915. https://doi.org/10.1093/rheumatology/kez533

Objectives. To investigate potential subgroups of primary care diagnosed patients with polymyalgia rheumatica (PMR) based on self-reported pain and stiffness severity over time.

Methods. 652 people with an incident PMR diagnosis were recruited fro... Read More about Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study.

Early Unplanned Readmissions after Admission to Hospital with Heart Failure (2019)
Journal Article
Helliwell, T., Clarson, L., Mallen, C., & Mamas, M. (2019). Early Unplanned Readmissions after Admission to Hospital with Heart Failure. American Journal of Cardiology, 736-745. https://doi.org/10.1016/j.amjcard.2019.05.053

Hospital readmissions remain a continued challenge in the care of patients with heart failure (HF). This study aims to examine the rates, temporal trends, predictors and causes of 30-day unplanned readmissions after admission with HF. Patients hospit... Read More about Early Unplanned Readmissions after Admission to Hospital with Heart Failure.

Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study (2019)
Journal Article
Mallen, Muller, Hider, & Helliwell. (2019). Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study. BMC Medicine, https://doi.org/10.1186/s12916-019-1394-6

Background
Antibiotic-induced disturbances of the human microbiota have been implicated in the development of chronic autoimmune conditions. This study aimed to assess whether antibiotic use is associated with the onset of rheumatoid arthritis (RA).... Read More about Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study.

Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey (2019)
Journal Article
Hider, S. L., Muller, S., Helliwell, T., Prior, J. A., Scott, I., Lawton, S. A., …Mallen, C. D. (2019). Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey. Rheumatology, 58(11), 2009-2014. https://doi.org/10.1093/rheumatology/kez184

Objectives: To describe the prevalence of self-reported inflammatory joint symptoms, such as joint pain, stiffness and swelling in UK primary care patients consulting for both musculoskeletal (MSK) and non-musculoskeletal (non-MSK) complaints.

Met... Read More about Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey.

Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice (2018)
Journal Article
Hider, S., Lawton, S., Muller, S., Helliwell, T., Zwierska, I., Mallen, C., & Richardson, J. (2018). Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice. British Journal of General Practice (BJGP), 68(676), E783-E793. https://doi.org/10.3399/bjgp18X699557

BACKGROUND: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older individuals. Most patients with PMR are diagnosed and managed exclusively in general practice, yet primary care-focused research is lack... Read More about Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice.

The real evidence for polymyalgia rheumatic as a paraneoplastic syndrome. (2018)
Journal Article
Muller, S., Hider, S., Helliwell, T., Partington, R., & Mallen, C. (2018). The real evidence for polymyalgia rheumatic as a paraneoplastic syndrome. Reumatismo, 118 - 119. https://doi.org/10.4081/reumatismo.2018.1166

Not available.

Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study (2018)
Journal Article
Mallen, Roddy, Bucknall, Muller, Hider, Helliwell, & Paskins. (2018). Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study. Osteoporosis International, 1659-1664. https://doi.org/10.1007/s00198-018-4491-z

This study aimed to examine fracture risk in patients with late-onset psoriasis. A cohort study was conducted using primary care records from the Clinical Practice Research Datalink. Psoriasis patients had a 10% increased risk of fracture compared to... Read More about Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study.

Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy (2018)
Journal Article
Paskins, Mallen, Bucknall, Hider, Muller, Helliwell, & Roddy. (2018). Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy. Canadian Medical Association Journal, E581 -E587. https://doi.org/10.1503/cmaj.170806

BACKGROUND: Previous studies that quantified the risk of fracture among patients with gout and assessed the potential effect of urate-lowering therapy have provided conflicting results. Our study aims to provide better estimates of risk by minimizing... Read More about Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy.

How can primary care physicians enhance the early diagnosis of rheumatic diseases? (2018)
Journal Article
Mallen, & Helliwell. (2018). How can primary care physicians enhance the early diagnosis of rheumatic diseases?. Expert Review of Clinical Immunology, 171-173. https://doi.org/10.1080/1744666X.2018.1429919

No abstract

Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study (2018)
Journal Article
Mallen, Roddy, Bucknall, Hider, Muller, Paskins, & Helliwell. (2018). Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study. BMC Medicine, https://doi.org/10.1186/s12916-017-0987-1

Background
Glucocorticoids are associated with increased fracture risk and are the mainstay of treatment in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). However, fracture risk in these conditions has not been previously quantified. T... Read More about Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study.

Polymyalgia rheumatica in primary care: an exploration of the challenges of diagnosis and management using survey and qualitative methods
Thesis
Helliwell, T. (2016). Polymyalgia rheumatica in primary care: an exploration of the challenges of diagnosis and management using survey and qualitative methods

Background: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older people and is closely related to giant cell arteritis (GCA). Most PMR patients are diagnosed and managed in general practice yet primary... Read More about Polymyalgia rheumatica in primary care: an exploration of the challenges of diagnosis and management using survey and qualitative methods.