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Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis (2019)
Presentation / Conference
Grose-Hodge, E., Carroll, W., Rainford, N., Gamble, C., & Gilchrist, F. (2019, September). Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis. Presented at ERS International Congress 2019, Madrid, Spain

Background: Protracted Bacterial Bronchitis (PBB) is a leading cause of chronic wet cough in children. Antibiotic response is a diagnostic criterion but there is little evidence to inform duration of treatment. Relapse is common and those who relapse... Read More about Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis.

Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres (2019)
Journal Article
Ditchfield, N., Carroll, W., & Gilchrist, F. (2019). Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.09.004

Highlights

IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA.

The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity.

More than one third of UK CF... Read More about Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres.

Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. (2005)
Journal Article
Carroll, W., Lenney, W., Jones, P., Strange, R., Child, F., Whyte, M., …Fryer, A. (2005). Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35(9), 1155 - 1161. https://doi.org/10.1111/j.1365-2222.2005.02313.x

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investiga... Read More about Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families..

Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. (2005)
Journal Article
Carroll, W., Lenney, W., Child, F., Strange, R., Jones, P., & Fryer, A. (2005). Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatric Allergy and Immunology, 16(1), 32 - 39. https://doi.org/10.1111/j.1399-3038.2005.00249.x

Maternal factors are known to influence the heritability and expression of asthma and atopy. We report the association of maternal, paternal and proband GSTP1 genotype with lung function in 145 Caucasian children with asthma. GSTP1 Val105/Val105 and... Read More about Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma..