Stigma associated with cutaneous and mucocutaneous leishmaniasis: A systematic review (2023)
Journal Article
Nuwangi, H., Agampodi, T. C., Price, H. P., Shepherd, T., Weerakoon, K., & Agampodi, S. (in press). Stigma associated with cutaneous and mucocutaneous leishmaniasis: A systematic review. PLoS Neglected Tropical Diseases, 17(12), Article e0011818. https://doi.org/10.1371/journal.pntd.0011818

Background
Cutaneous (CL) and mucocutaneous leishmaniasis (MCL) are parasitic diseases caused by parasites of the genus leishmania leading to stigma caused by disfigurations. This study aimed to systematically review the dimensions, measurement meth... Read More about Stigma associated with cutaneous and mucocutaneous leishmaniasis: A systematic review.

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence (2022)
Journal Article
Mallikarjun, V., Dobre, O., Jackson, M., Kidd, M., Llewellyn, J., Gilbert, H., …Swift, J. (2022). Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence. arXiv,

ABSTRACT Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche exp... Read More about Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., …Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

<jats:p>Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Ratings of perceived exertion at the ventilatory anaerobic threshold in people with coronary heart disease: A CARE CR study. (2021)
Journal Article
Nichols, S., Engin, B., Carroll, S., Buckley, J., & Ingle, L. (2021). Ratings of perceived exertion at the ventilatory anaerobic threshold in people with coronary heart disease: A CARE CR study. Annals of Physical and Rehabilitation Medicine, 101462 - ?. https://doi.org/10.1016/j.rehab.2020.101462

BACKGROUND: Exercise prescription guidelines for individuals undergoing cardiovascular rehabilitation (CR) are often based on heart rate training zones and rating of perceived exertion (RPE). United Kingdom guidelines indicate that patients should ex... Read More about Ratings of perceived exertion at the ventilatory anaerobic threshold in people with coronary heart disease: A CARE CR study..

CERTL reduces C16 ceramide, amyloid-ß levels, and inflammation in a model of Alzheimer's disease (2021)
Journal Article
(2021). CERTL reduces C16 ceramide, amyloid-ß levels, and inflammation in a model of Alzheimer's disease. Alzheimer's Research and Therapy, 45 -?. https://doi.org/10.1186/s13195-021-00780-0

BACKGROUND: Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer's disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers which are crucial for ceramide and sphingomyeli... Read More about CERTL reduces C16 ceramide, amyloid-ß levels, and inflammation in a model of Alzheimer's disease.

Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences. (2020)
Journal Article
Buckley, J., Riddell, M., Mellor, D., Bracken, R., Poirier, P., LaGerche, A., & Ross, M. (2020). Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2020-102446

Type 1 (T1) and type 2 (T2) diabetes mellitus (DM) are significant precursors and comorbidities to cardiovascular disease and prevalence of both types is still rising globally. Currently,~25% of participants (and rising) attending cardiac rehabilitat... Read More about Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences..

The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy. (2020)
Journal Article
Samia, P., Williams, F., Taylor, S., Lindoewood, R., Barton, C., & Buckley, J. (2020). The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy. Disability and Rehabilitation: Assistive Technology, 1 - 11. https://doi.org/10.1080/17483107.2020.1830442

PURPOSE: Appropriate paper-based technology (APT) is used to provide postural support for children with cerebral palsy (CP) in low-resourced settings. This pilot study aimed to evaluate the impact of APT on the children's and families' lives. MATERIA... Read More about The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy..

The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum (2020)
Thesis
Anagu, L. O. (2020). The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum. (Thesis). Keele University

Plasmodium falciparum encodes a family of key virulence genes called var genes. These encode adhesive proteins that are expressed on infected erythrocytes in a mutually exclusive manner. The parasite’s sirtuins have been implicated in epigenetic sele... Read More about The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum.

ARF regulating proteins as novel drug targets in Trypanosoma brucei (2020)
Thesis
Chandrathas, J. P. (2020). ARF regulating proteins as novel drug targets in Trypanosoma brucei. (Thesis). Keele University

Human African Trypanosomiasis (HAT) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases that pose a huge socioeconomic and health burden in poorer countries in sub-Saharan Africa. The causative agents of these diseases are the Tr... Read More about ARF regulating proteins as novel drug targets in Trypanosoma brucei.

Promoting Patient Utilization of Outpatient Cardiac Rehabilitation: A JOINT INTERNATIONAL COUNCIL AND CANADIAN ASSOCIATION OF CARDIOVASCULAR PREVENTION AND REHABILITATION POSITION STATEMENT. (2020)
Journal Article
Santiago de Araújo Pio, C., Beckie, T., Varnfield, M., Sarrafzadegan, N., Babu, A., Baidya, S., …Grace, S. (2020). Promoting Patient Utilization of Outpatient Cardiac Rehabilitation: A JOINT INTERNATIONAL COUNCIL AND CANADIAN ASSOCIATION OF CARDIOVASCULAR PREVENTION AND REHABILITATION POSITION STATEMENT. Journal of Cardiopulmonary Rehabilitation and Prevention, 79 - 86. https://doi.org/10.1097/HCR.0000000000000474

PURPOSE: Cardiac rehabilitation (CR) is a recommendation in international clinical practice guidelines given its benefits; however, use is suboptimal. The purpose of this position statement was to translate evidence on interventions that increase CR... Read More about Promoting Patient Utilization of Outpatient Cardiac Rehabilitation: A JOINT INTERNATIONAL COUNCIL AND CANADIAN ASSOCIATION OF CARDIOVASCULAR PREVENTION AND REHABILITATION POSITION STATEMENT..

Aluminium in Brain Tissue in Non-neurodegenerative/Non-neurodevelopmental Disease: A Comparison with Multiple Sclerosis (2020)
Journal Article
(2020). Aluminium in Brain Tissue in Non-neurodegenerative/Non-neurodevelopmental Disease: A Comparison with Multiple Sclerosis. Exposure and Health, https://doi.org/10.1007/s12403-020-00346-9

Human exposure to aluminium is a burgeoning issue. The brain is a sink for systemically available aluminium and a putative target of neurotoxicity. An increasing number of studies continue to confirm the presence of aluminium in human brain tissue th... Read More about Aluminium in Brain Tissue in Non-neurodegenerative/Non-neurodevelopmental Disease: A Comparison with Multiple Sclerosis.

Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis (2020)
Journal Article
Hammad, D., Hider, S., Liyanapathirana, V., & Tonge, D. (2020). Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis. Frontiers in Cellular and Infection Microbiology, 9, Article 440. https://doi.org/10.3389/fcimb.2019.00440

Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date, such studies have mainly focused on the microbial c... Read More about Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis.

Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models (2019)
Thesis
Andoh, N. E. (2019). Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413819

During cerebral malaria (CM), sequestration of Plasmodium falciparum infected red blood cells (PRBC) to the blood-brain barrier (BBB) is associated with BBB disruption and long-term neurological sequelae in CM survivors, possibly linked to the activa... Read More about Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models.

Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma (2019)
Journal Article
Tonge. (2019). Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma. Scientific reports, 9, Article 8912. https://doi.org/10.1038/s41598-019-45257-1

Asthma is a chronic inflammatory disorder of the airways. Disease presentation varies greatly in terms of cause, development, severity, and response to medication, and thus the condition has been subdivided into a number of asthma phenotypes. There i... Read More about Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma.

A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. (2019)
Journal Article
Mycroft-West, C., Cooper, L., Devlin, A., Procter, P., Guimond, S., Guerrini, M., …Skidmore, M. (2019). A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. Marine Drugs, 17, 293 -293. https://doi.org/10.3390/md17050293

Therapeutic options for Alzheimer's disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan heparin, widely used as a clinical anticoagulant, has previously been shown to inhibit the Alzheim... Read More about A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease..

Intracellular tracing of amyloid vaccines through direct fluorescent labelling. (2018)
Journal Article
(2018). Intracellular tracing of amyloid vaccines through direct fluorescent labelling. Scientific reports, 2437 - ?. https://doi.org/10.1038/s41598-018-20845-9

Alzheimer's disease is a debilitating neurodegenerative condition that progressively causes synaptic loss and major neuronal damage. Immunotherapy utilising Aß as an active immunogen or via passive treatment utilising antibodies raised to amyloid hav... Read More about Intracellular tracing of amyloid vaccines through direct fluorescent labelling..

Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis (2017)
Journal Article
(2017). Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis. EBioMedicine, 60-67. https://doi.org/10.1016/j.ebiom.2017.10.028

AbstractBackground Progressive multiple sclerosis is a chronic autoimmune condition of unknown aetiology and few therapeutic options. Human exposure to aluminium has been linked with multiple sclerosis and affected individuals are known to excrete un... Read More about Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis.

Cardiac Rehabilitation Delivery Model for Low-Resource Settings: An International Council of Cardiovascular Prevention and Rehabilitation Consensus Statement. (2016)
Journal Article
Grace, S., Turk-Adawi, K., Contractor, A., Atrey, A., Campbell, N., Derman, W., …Sarrafzadegan, N. (2016). Cardiac Rehabilitation Delivery Model for Low-Resource Settings: An International Council of Cardiovascular Prevention and Rehabilitation Consensus Statement. Progress in Cardiovascular Diseases, 303 - 322. https://doi.org/10.1016/j.pcad.2016.08.004

Cardiovascular disease (CVD) is a global epidemic, which is largely preventable. Cardiac rehabilitation (CR) is demonstrated to be efficacious and cost-effective for secondary prevention in high-income countries. Given its affordability, CR should be... Read More about Cardiac Rehabilitation Delivery Model for Low-Resource Settings: An International Council of Cardiovascular Prevention and Rehabilitation Consensus Statement..

Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48
Journal Article
(2015). Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48. https://doi.org/10.7243/2050-0866-4-4

Background: IAPP1-37 and ProIAPP1-48 are amyloidogenic peptides implicated in ß-cell death in diabetes. Interactions with metals may be involved in both the cytotoxicity of these peptides and their deposition as amyloids associated with diabetes-rela... Read More about Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48.