Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data (2023)
Thesis
Huang, X. (2023). Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data. (Thesis). Keele University

For adults aged 45 and over in the United Kingdom (UK), osteoarthritis is a common reason for consultation with primary care. Cardiovascular disease (CVD) is a common comorbidity with osteoarthritis; two in five people with osteoarthritis also have C... Read More about Exploring cardiovascular risk and outcomes in primary care consulters for osteoarthritis using longitudinal electronic primary care data.

Assessing the impact of comorbidity measures on outcomes following acute coronary syndrome (2022)
Thesis
Zhang, F. (2022). Assessing the impact of comorbidity measures on outcomes following acute coronary syndrome. (Thesis). Keele University

Acute coronary syndromes (ACS) are a common acute presentation of cardiovascular disease (CVD) associated with significant morbidity, mortality and societal economic burden. With improvements in medical care and post- ACS survival rates, ACS patients... Read More about Assessing the impact of comorbidity measures on outcomes following acute coronary syndrome.

An interpretive phenomenological study of nursing insights into the formation of the therapeutic nurse patient relationship within acute psychiatric wards (2022)
Thesis
Fieldhouse, C. J. (2022). An interpretive phenomenological study of nursing insights into the formation of the therapeutic nurse patient relationship within acute psychiatric wards. (Thesis). Keele University

This study has concerned itself with the therapeutic nature of the relationship between psychiatric nurses and the inpatients of acute psychiatric wards. In particular it sought the insights that those nurses held in relation to their strategic endea... Read More about An interpretive phenomenological study of nursing insights into the formation of the therapeutic nurse patient relationship within acute psychiatric wards.

A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia (2022)
Thesis
Chacko, S. M. (2022). A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia. (Thesis). Keele University

Introduction: Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns. Advances in metabolomics have extended our capabilities to define these metabolic perturbat... Read More about A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia.

Benchmarking community and primary care musculoskeletal services: Developing recommendations using evidence syntheses, consensus methods and secondary data analysis (2022)
Thesis
Burgess, R. M. (2022). Benchmarking community and primary care musculoskeletal services: Developing recommendations using evidence syntheses, consensus methods and secondary data analysis. (Thesis). Keele University

Introduction: High quality data on service performance is essential in healthcare. There is however a paucity of publicly reported data in community/primary care musculoskeletal (MSK) services. There is also a lack of guidance on which metrics servic... Read More about Benchmarking community and primary care musculoskeletal services: Developing recommendations using evidence syntheses, consensus methods and secondary data analysis.

Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells (2021)
Thesis
Hyland, M. (2021). Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells. (Thesis). Keele University

Rheumatoid Arthritis (RA) is a chronic autoimmune disease which is characterised by a loss of immune tolerance, and an infiltration of immune cells into joints causing inflammation. Current pharmaceutical treatments for RA have adverse side effects a... Read More about Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells.

Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study (2021)
Thesis
Barnett, L. A. (2021). Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study. (Thesis). Keele University

Background: Giant cell arteritis (GCA) is the most common form of medium and large vessel vasculitis. This condition is associated with serious complications, such as blindness if left untreated, and is therefore considered a medical emergency. Howev... Read More about Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study.

Patient-related factors influencing management and procedural outcomes of de novo cardiac electronic device implantation (2021)
Thesis
Mohamed, M. O. A. H. (2021). Patient-related factors influencing management and procedural outcomes of de novo cardiac electronic device implantation. (Thesis). Keele University

Cardiac implantable electronic devices (CIED) are an essential part of the management of patients with life threatening arrhythmias. While many patient-related factors have been previously shown to play a role in the choice of CIED type offered to pa... Read More about Patient-related factors influencing management and procedural outcomes of de novo cardiac electronic device implantation.

Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications (2021)
Thesis
Wang, J. (2021). Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications. (Thesis). Keele University

As a vital part of the knee joint, the meniscus acts to prevent the degeneration of articular cartilage and the onset of knee osteoarthritis (OA). Repairing meniscus injuries in the avascular region is still a challenge in orthopaedics. The current p... Read More about Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications.

Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs (2021)
Thesis
Alansari, R. H. A. (2021). Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs. (Thesis). Keele University

The human body hosts a vast number of microorganisms such as bacteria, archaea, and viruses that are colonised inside and outside the body. This combination of microorganisms living within the human body is known as microbiota. The human microbiota v... Read More about Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs.

Views and experiences of informal caregivers of older adults with dementia in Sri Lanka: a phenomenological study (2021)
Thesis
Abhayasinghe, M. P. K. W. (2021). Views and experiences of informal caregivers of older adults with dementia in Sri Lanka: a phenomenological study. (Thesis). Keele University

Introduction:
Dementia is a global health concern affecting an estimated 115.4 million people. Dementia has become a research priority in low-and-middle income countries (LAMIC), due to increasing prevalence associated with demographic transition an... Read More about Views and experiences of informal caregivers of older adults with dementia in Sri Lanka: a phenomenological study.

Investigating the use of stratified primary care for older adults with musculoskeletal pain: a mixed methods study (2021)
Thesis
Birkinshaw, H. (2021). Investigating the use of stratified primary care for older adults with musculoskeletal pain: a mixed methods study. (Thesis). Keele University

Introduction
Musculoskeletal pain is common in older adults (aged =65), but current assessment and management in primary care is suboptimal. Prognostic stratified care matches treatment options to patients based upon their risk of persistent pain si... Read More about Investigating the use of stratified primary care for older adults with musculoskeletal pain: a mixed methods study.

Application of propensity scores and marginal structural models evaluating the effect of allopurinol in gout using primary care medical records (2021)
Thesis
Rathod-Mistry, T. (2021). Application of propensity scores and marginal structural models evaluating the effect of allopurinol in gout using primary care medical records. (Thesis). Keele University

Background
Primary care electronic health records (EHR) capture real life patterns of healthcare utilisation over time. This provides the opportunity to estimate the effect of allopurinol on long term outcomes in people with gout. However, use of su... Read More about Application of propensity scores and marginal structural models evaluating the effect of allopurinol in gout using primary care medical records.

The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data (2021)
Thesis
Henry-Blake, C. J. (2021). The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data. (Thesis). Keele University

The National Institute for Health and Care Excellence (NICE) suggests there is no role for routine radiography in the diagnosis of osteoarthritis (OA). It is not known how consistent this recommendation is across guidelines, or the impact of guidelin... Read More about The impact of guidelines on the use of imaging in osteoarthritis: a time trend analysis using electronic health record data.

Physical activity in people with osteoarthritis and comorbidity: a multi-method study (2021)
Thesis
McKevitt, S. (2021). Physical activity in people with osteoarthritis and comorbidity: a multi-method study. (Thesis). Keele University

Osteoarthritis (OA) is common and associated with one of the highest comorbidity rates. OA clinical guidelines recommend physical activity (PA) as core treatment, irrespective of comorbidity. However, no current synthesis of the effectiveness of PA f... Read More about Physical activity in people with osteoarthritis and comorbidity: a multi-method study.

Gout flares and health-related quality of life in people living with gout: a prospective cohort study in primary care (2020)
Thesis
Watson, L. (2020). Gout flares and health-related quality of life in people living with gout: a prospective cohort study in primary care. (Thesis). Keele University

Background
Gout is a common inflammatory arthritis affecting an estimated 2.5% of the UK population. The hallmark of gout is sudden onset, extremely painful acute inflammatory flares, which are strongly associated with impaired health-related qualit... Read More about Gout flares and health-related quality of life in people living with gout: a prospective cohort study in primary care.

Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways (2020)
Thesis
Šoltić, D. (2020). Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways. (Thesis). Keele University

Spinal muscular atrophy (SMA) is a debilitating genetic disorder, characterised by homozygous loss of the survival of motor neuron 1 (SMN1) gene, resulting in insufficient levels of ubiquitously expressed survival of motor neuron (SMN) protein. The t... Read More about Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways.

The epidemiology, prognosis and management of carpal tunnel syndrome in primary care (2020)
Thesis
Burton, C. L. (2020). The epidemiology, prognosis and management of carpal tunnel syndrome in primary care. (Thesis). Keele University

Carpal tunnel syndrome (CTS) is a compression neuropathy of the median nerve. Patients may experience discomfort in the hand and wrist, altered sensation and functional deficit. The management of mild to moderate CTS involves local corticosteroid inj... Read More about The epidemiology, prognosis and management of carpal tunnel syndrome in primary care.

ARF regulating proteins as novel drug targets in Trypanosoma brucei (2020)
Thesis
Chandrathas, J. P. (2020). ARF regulating proteins as novel drug targets in Trypanosoma brucei. (Thesis). Keele University

Human African Trypanosomiasis (HAT) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases that pose a huge socioeconomic and health burden in poorer countries in sub-Saharan Africa. The causative agents of these diseases are the Tr... Read More about ARF regulating proteins as novel drug targets in Trypanosoma brucei.

An observational evaluation of 30-day unplanned readmissions after percutaneous coronary intervention in the United States (2020)
Thesis
Kwok, C. S. (2020). An observational evaluation of 30-day unplanned readmissions after percutaneous coronary intervention in the United States. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417204

Percutaneous coronary intervention (PCI) has become one of the most commonly performed procedures in hospital used to treat coronary heart disease. As PCI has evolved into a safe procedure with low mortality rates, however, there is now a growing pop... Read More about An observational evaluation of 30-day unplanned readmissions after percutaneous coronary intervention in the United States.