The symptomatic course of foot osteoarthritis phenotypes: an 18-month prospective analysis of community-dwelling older adults. (2017)
Journal Article
Downes, T. J., Chesterton, L., Whittle, R., Roddy, E., Menz, H. B., Marshall, M., & Thomas, M. J. (2018). The symptomatic course of foot osteoarthritis phenotypes: an 18-month prospective analysis of community-dwelling older adults. Arthritis Care and Research, 70(7), 1107-1112. https://doi.org/10.1002/acr.23502

OBJECTIVE: Osteoarthritis (OA) is a heterogeneous disease with symptom progression at the foot unclear. This study investigated the symptomatic course of three pre-defined foot OA phenotypes over an 18-month period. METHODS: The Clinical Assessment S... Read More about The symptomatic course of foot osteoarthritis phenotypes: an 18-month prospective analysis of community-dwelling older adults..

Population-level impact of diabetes integrated care on commissioner payments for inpatient care among people with type 2 diabetes in Cambridgeshire: a postintervention cohort follow-up study (2017)
Journal Article
Yu. (2017). Population-level impact of diabetes integrated care on commissioner payments for inpatient care among people with type 2 diabetes in Cambridgeshire: a postintervention cohort follow-up study. BMJ Open, https://doi.org/10.1136/bmjopen-2017-015816

Objectives Few studies have estimated the effect of diabetes integrated care at a population level. We have assessed the impact of introducing a community service-led diabetes integrated care programme on commissioner payments (tariff) for inpatient... Read More about Population-level impact of diabetes integrated care on commissioner payments for inpatient care among people with type 2 diabetes in Cambridgeshire: a postintervention cohort follow-up study.

Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. (2017)
Journal Article
Van Der Windt, Holden, & Dziedzic. (2017). Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. BMJ Open, e018971 - ?. https://doi.org/10.1136/bmjopen-2017-018971

INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physic... Read More about Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol..

Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour (2017)
Journal Article
Finney, A., Dziedzic, K., Lewis, A., & Healey, E. (2017). Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour. BMC Musculoskeletal Disorders, 18, Article 535. https://doi.org/10.1186/s12891-017-1896-3

Background
Research into musculoskeletal conditions often focusses on pain at single sites, such as the knee, yet several studies have previously reported the high prevalence of multiple sites of musculoskeletal pain. The most common form of musculo... Read More about Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour.

Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register (2017)
Journal Article
Mamas. (2017). Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register. Journal of the Neurological Sciences, 26-30. https://doi.org/10.1016/j.jns.2017.09.047

AbstractBackground Previous research has demonstrated an association between anaemia and poor outcomes in acute stroke. This study aimed to assess the impact of anaemia on stroke by anaemia subtype. Methods Data from a prospective UK Regional Stroke... Read More about Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register.

The effect of variation in interpretation of the La Trobe radiographic foot atlas on the prevalence of foot osteoarthritis in older women: the Chingford general population cohort. (2017)
Journal Article
McQueen, P., Gates, L., Marshall, M., Doherty, M., Arden, N., & Bowen, C. (in press). The effect of variation in interpretation of the La Trobe radiographic foot atlas on the prevalence of foot osteoarthritis in older women: the Chingford general population cohort. Journal of Foot and Ankle Research, 10, Article 54. https://doi.org/10.1186/s13047-017-0239-9

Background: The prevalence of foot osteoarthritis (OA) is much less understood than hip, knee and hand OA. The foot is anatomically complex and different researchers have investigated different joints with lack of methodological standardisation acros... Read More about The effect of variation in interpretation of the La Trobe radiographic foot atlas on the prevalence of foot osteoarthritis in older women: the Chingford general population cohort..

The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol (2017)
Journal Article
Healey, E., Jinks, C., Foster, N., Chew-Graham, Chew-Graham, C., Pincus, T., …McBeth, J. (2017). The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol. Musculoskeletal Care, 16(1), https://doi.org/10.1002/msc.1222

INTRODUCTION: This pilot trial will inform the design and methods of a future full-scale randomized controlled trial (RCT) and examine the feasibility, acceptability and fidelity of the Increasing Physical activity in Older People with chronic Pain (... Read More about The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol.

A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation (2017)
Journal Article
Mamas. (2017). A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation. Heart, 1109-1116. https://doi.org/10.1136/heartjnl-2017-312489

Objective Existing clinical prediction models (CPM) for short-term mortality after transcatheter aortic valve implantation (TAVI) have limited applicability in the UK due to moderate predictive performance and inconsistent recording practices across... Read More about A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation.

Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST). (2017)
Journal Article
Barnett, L., Mallen, C., Lewis, A., & Peat, G. (2017). Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST). Trials, 18, 585 - ?. https://doi.org/10.1186/s13063-017-2329-1

BACKGROUND: Selection bias is a concern when designing cluster randomised controlled trials (c-RCT). Despite addressing potential issues at the design stage, bias cannot always be eradicated from a trial design. The application of bias analysis prese... Read More about Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST)..

Impact of Access Site Practice on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention Following Thrombolysis for ST-Segment Elevation Myocardial Infarction in the United Kingdom : An Insight From the British Cardiovascular Intervention Society Dataset (2017)
Journal Article
Rashid, M., Rushton, C. A., Kwok, C. S., Kinnaird, T., Kontopantelis, E., Olier, I., …Mamas, M. (2017). Impact of Access Site Practice on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention Following Thrombolysis for ST-Segment Elevation Myocardial Infarction in the United Kingdom : An Insight From the British Cardiovascular Intervention Society Dataset. JACC. Cardiovascular interventions, 10(22), 2258 -2265. https://doi.org/10.1016/j.jcin.2017.07.049

Objectives
This study sought to examine the relationship between access site practice and clinical outcomes in patients requiring percutaneous coronary intervention (PCI) following thrombolysis for ST-segment elevation myocardial infarction (STEMI).... Read More about Impact of Access Site Practice on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention Following Thrombolysis for ST-Segment Elevation Myocardial Infarction in the United Kingdom : An Insight From the British Cardiovascular Intervention Society Dataset.

Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort (2017)
Journal Article
Konstantinou, K., Dunn, K., Ogollah, R., Lewis, M., Van Der Windt, D., Hay, E., & Study Team, A. (2017). Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort. Spine Journal, 1030-1040. https://doi.org/10.1016/j.spinee.2017.10.071

Background Context
Evidence is lacking on the prognosis and prognostic factors of back-related leg pain and sciatica in patients seeing their primary care physicians. This evidence could guide timely appropriate treatment and referral decisions.... Read More about Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort.

Longitudinal deformation bench testing using a coronary artery model: a new standard? (2017)
Journal Article
Mamas. (2017). Longitudinal deformation bench testing using a coronary artery model: a new standard?. Open Heart, https://doi.org/10.1136/openhrt-2016-00053

Objectives To compare susceptibility of five different stent platforms with longitudinal stent deformation (LSD) using a clinically relevant bench testing model simulating both short and long malapposed lengths. Background Recent data suggest that de... Read More about Longitudinal deformation bench testing using a coronary artery model: a new standard?.

Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide (2017)
Journal Article
Mamas. (2017). Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide. FEBS Open Bio, 1672 -1685. https://doi.org/10.1002/2211-5463.12284

Advanced glycation end products (AGE) are central to the development of cardiovascular complications associated with diabetes mellitus. AGE may alter cellular function through cross-linking of cellular proteins or by activating the AGE receptor (RAGE... Read More about Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide.

Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis (2017)
Journal Article
(2017). Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis. EBioMedicine, 60-67. https://doi.org/10.1016/j.ebiom.2017.10.028

AbstractBackground Progressive multiple sclerosis is a chronic autoimmune condition of unknown aetiology and few therapeutic options. Human exposure to aluminium has been linked with multiple sclerosis and affected individuals are known to excrete un... Read More about Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis.

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article
Roddy, Mallen, Clarson, Belcher, & Hider. (2017). Factors Influencing Allopurinol Initiation in Primary Care. Annals of Family Medicine, 15(6), 557 - 560. https://doi.org/10.1370/afm.213

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register (2017)
Journal Article
(2017). Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register. Arthritis and Rheumatology, 2144 - 2150. https://doi.org/10.1002/art.40185

Objective. To estimate the proportion of patients with axial spondyloarthritis (SpA) in a UK national biologics registry who met criteria for fibromyalgia (FM), and to delineate the characteristics of these patients. Methods. Two cohorts of patients... Read More about Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia Results From a UK National Register.

Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). (2017)
Journal Article
Iskandar, I. Y., Warren, R. B., Lunt, M., Mason, K. J., Evans, I., McElhone, K., …Griffiths, C. E. (2018). Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). Journal of Investigative Dermatology, 138(4), 775 - 784. https://doi.org/10.1016/j.jid.2017.09.044

Little is known about the drug survival of second-line biologic therapies for psoriasis in routine clinical practice. We assessed drug survival of second-line biologic therapies and estimated the risk of recurrent discontinuation due to adverse event... Read More about Differential Drug Survival of Second-Line Biologic Therapies in Patients with Psoriasis: Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR)..

Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry (2017)
Journal Article
Mamas. (2017). Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry. JACC. Cardiovascular interventions, 2040-2047. https://doi.org/10.1016/j.jcin.2017.05.020

Objectives
This study sought to determine the risk factors for post-transcatheter aortic valve replacement (TAVR) dialysis and to determine the impact of pre-TAVR or post-TAVR dialysis on mortality.

Background
TAVR is now established as an alter... Read More about Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry.

Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population? (2017)
Journal Article
Mamas. (2017). Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population?. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.117.007229

Background
Transcatheter aortic valve implantation (TAVI) is indicated for patients with aortic stenosis who are intermediate-high surgical risk. Although all-cause mortality rates after TAVI are established, survival attributable to the procedure i... Read More about Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population?.

Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial (2017)
Journal Article
Dziedzic, K., Hay, E., Porcheret, M., Afolabi, E., Lewis, A., Morden, A., …Healey, E. (2018). Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial. Osteoarthritis and Cartilage, 26(1), 43-53. https://doi.org/10.1016/j.joca.2017.09.010

Objective
To determine the effectiveness of a model osteoarthritis consultation, compared with usual care, on physical function and uptake of National Institute for Health and Care Excellence (NICE) osteoarthritis recommendations, in adults =45 year... Read More about Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): A cluster randomised controlled trial.