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Development and application of multivariate meta-analysis in medical research: borrowing strength across multiple correlated outcomes (2019)
Thesis
Hattle, M. S. M. (2019). Development and application of multivariate meta-analysis in medical research: borrowing strength across multiple correlated outcomes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415208

Multivariate meta-analysis methods combine effect estimates for multiple correlated outcomes (such as systolic and diastolic blood pressure) from independent studies, utilising their between-study and within-study correlations. In contrast, a univari... Read More about Development and application of multivariate meta-analysis in medical research: borrowing strength across multiple correlated outcomes.

Assessment of fracture risk tools in care home residents (2019)
Thesis
Ihama, F. E. (2019). Assessment of fracture risk tools in care home residents. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415215

Introduction
Fragility fractures are common in care home residents. National guidelines recommend risk assessment to allow initiation of prophylactic measures. Currently available risk assessment tools have been tested in community dwelling adults b... Read More about Assessment of fracture risk tools in care home residents.

If it's 'only' asthma, why are children still dying? (2019)
Journal Article
(2019). If it's 'only' asthma, why are children still dying?. Archives of Disease in Childhood, 494 - 498. https://doi.org/10.1136/archdischild-2019-318215

Outcomes for children with asthma in the UK continue to lag behind other European countries. Mortality remains unacceptably high and in contrast to adults with asthma, most deaths occur in the 1 in 20 children with asthma who have severe asthma. Desp... Read More about If it's 'only' asthma, why are children still dying?.

Outcomes of patients who undergo percutaneous coronary intervention with covered stents for coronary perforation: A systematic review and pooled analysis of data (2019)
Journal Article
(2019). Outcomes of patients who undergo percutaneous coronary intervention with covered stents for coronary perforation: A systematic review and pooled analysis of data. Catheterization and Cardiovascular Interventions, https://doi.org/10.1002/ccd.28646

OBJECTIVES: This review aims to evaluate the adverse outcomes for patients after treatment with covered stents. BACKGROUND: Coronary perforation is a potentially fatal complication of percutaneous coronary revascularization which may be treated using... Read More about Outcomes of patients who undergo percutaneous coronary intervention with covered stents for coronary perforation: A systematic review and pooled analysis of data.

Research priorities for the management of broken bones of the upper limb in people over 50: a UK priority setting partnership with the James Lind Alliance (2019)
Journal Article
Sheehan, W. J., Williams, M. A., Paskins, Z., Costa, M. L., Antonio Fernandez, M., Gould, J., …Gwilym, S. (2019). Research priorities for the management of broken bones of the upper limb in people over 50: a UK priority setting partnership with the James Lind Alliance. BMJ Open, e030028 - ?. https://doi.org/10.1136/bmjopen-2019-030028

OBJECTIVE: To determine research priorities for the management of broken bones of the upper limb in people over 50, which represent the shared priorities of patients, their families, carers and healthcare professionals. DESIGN/SETTING: A national (UK... Read More about Research priorities for the management of broken bones of the upper limb in people over 50: a UK priority setting partnership with the James Lind Alliance.

Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials. (2019)
Journal Article
Legha, A., Burke, D. L., Foster, N. E., Van Der Windt, D. A., Quicke, J. G., Healey, E. L., …Holden, M. A. (2020). Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials. Musculoskeletal Care, 18(1), 3-11. https://doi.org/10.1002/msc.1425

BACKGROUND: Although exercise is a core treatment for people with knee osteoarthritis (OA), it is currently unknown whether those with additional comorbidities respond differently to exercise than those without. We explored whether comorbidities pred... Read More about Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials..

Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study (2019)
Journal Article
Moore, A. J., Holden, M. A., Foster, N. E., & Jinks, C. (2020). Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study. Journal of Physiotherapy, 66(1), 45-53. https://doi.org/10.1016/j.jphys.2019.11.004

Objectives: To investigate patients’ experiences and impact of physiotherapist (physical therapist) led exercise interventions for knee pain attributable to osteoarthritis, and to explore barriers and facilitators to change in exercise and physical a... Read More about Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study.

Sex differences in rates and causes of 30-day readmissions after cardiac electronic device implantations: insights from the Nationwide Readmissions Database (2019)
Journal Article
Mamas. (2019). Sex differences in rates and causes of 30-day readmissions after cardiac electronic device implantations: insights from the Nationwide Readmissions Database. International Journal of Cardiology, https://doi.org/10.1016/j.ijcard.2019.12.012

Background

Women undergoing cardiac implantable electronic device (CIED) implantation are at a higher risk of procedure-related complications. The present study examined sex differences in rates and causes of 30-day readmissions following CIED imp... Read More about Sex differences in rates and causes of 30-day readmissions after cardiac electronic device implantations: insights from the Nationwide Readmissions Database.

Calcification Microstructure Reflects Breast Tissue Microenvironment (2019)
Journal Article
Gosling, S., Scott, R., Greenwood, C., Bouzy, P., Nallala, J., D. Lyburn, I., …Rogers, K. (2019). Calcification Microstructure Reflects Breast Tissue Microenvironment. Journal of Mammary Gland Biology and Neoplasia, 333-342. https://doi.org/10.1007/s10911-019-09441-3

Microcalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. Hydroxyapatite microcalcific... Read More about Calcification Microstructure Reflects Breast Tissue Microenvironment.

Spontaneity and serendipity: Space and time in the lives of people with diabetes (2019)
Journal Article
Lucherini, M. (2020). Spontaneity and serendipity: Space and time in the lives of people with diabetes. Social Science and Medicine, 245, Article ARTN 112723. https://doi.org/10.1016/j.socscimed.2019.112723

This article considers the relevance of non-representational theory to understanding the lived experience of diabetes. While non-representational theory has gained traction in the social sciences, especially Human Geography, its usefulness in extendi... Read More about Spontaneity and serendipity: Space and time in the lives of people with diabetes.

Naproxen or low-dose colchicine for gout flares in primary care? Response to: 'Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care' by Parperis et al. (2019)
Journal Article
Roddy, E., & Mallen, C. (2019). Naproxen or low-dose colchicine for gout flares in primary care? Response to: 'Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care' by Parperis et al. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2019-216671

Correspondence response.

Acute myocardial infarction treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the USA (2019)
Journal Article
Bharadwaj, A., Potts, J., Mohamed, M. O., Parwani, P., Swamy, P., Lopez-Mattei, J. C., …Mamas, M. A. (2020). Acute myocardial infarction treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the USA. European Heart Journal, 41(23), 2183-2193. https://doi.org/10.1093/eurheartj/ehz851

Aim:
The aim of this study is to evaluate temporal trends, treatment and clinical outcomes of patients who present with an acute myocardial infarction (AMI) and have a current or historical diagnosis of cancer, according to cancer type and presence... Read More about Acute myocardial infarction treatments and outcomes in 6.5 million patients with a current or historical diagnosis of cancer in the USA.

Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records. (2019)
Journal Article
Chen, Y., Farooq, S., Edwards, J., Chew-Graham, C. A., Shiers, D., Frisher, M., …Jordan, K. P. (2019). Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records. BMC Medicine, 17, Article 227. https://doi.org/10.1186/s12916-019-1462-y

Background: The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine patterns of symptoms recorded in primary care in the 5-years before FEP diagnosis.

Methods: The study was s... Read More about Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records..

A low-cost laboratory-based method for predicting newly diagnosed biopsy-proven diabetic nephropathy in people with type 2 diabetes (2019)
Journal Article
Yu, D., Shang, J., Cai, Y., Wang, Z., Zhao, B., Zhao, Z., & Simmons, D. (2020). A low-cost laboratory-based method for predicting newly diagnosed biopsy-proven diabetic nephropathy in people with type 2 diabetes. Diabetic Medicine, 37(10), 1728-1736. https://doi.org/10.1111/dme.14195

Aims

To identify significant prognostic factors for newly diagnosed biopsy-proven diabetic nephropathy using routine laboratory measures, from which to derive a low-cost explanatory model, and to use this model to examine associations between the... Read More about A low-cost laboratory-based method for predicting newly diagnosed biopsy-proven diabetic nephropathy in people with type 2 diabetes.

The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation. (2019)
Journal Article
Mamas, & Nolan. (2019). The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation. Heart, Lung and Circulation, 1827-1834. https://doi.org/10.1016/j.hlc.2018.11.006

BACKGROUND: Aortic stenosis (AS) is a common valvular abnormality and transcatheter aortic valve implantation (TAVI) is being increasingly used to treat patients considered too high risk for conventional surgery. We aimed to assess the prevalence of... Read More about The Influence of the Charlson Comorbidity Index on Procedural Characteristics, VARC-2 Endpoints and 30-Day Mortality Among Patients Who Undergo Transcatheter Aortic Valve Implantation..

Risk Factors for Non-Communicable Diseases at Baseline and Their Short-Term Changes in a Workplace Cohort in Singapore (2019)
Journal Article
Sathish, T., Dunleavy, G., Soljak, M., Visvalingam, N., Divakar, U., Thach, T., …Car, J. (2019). Risk Factors for Non-Communicable Diseases at Baseline and Their Short-Term Changes in a Workplace Cohort in Singapore. International Journal of Environmental Research and Public Health, 16(22), 1-11. https://doi.org/10.3390/ijerph16224551

We aimed to examine the behavioural and clinical risk factors for non-communicable diseases (NCDs) at baseline and their changes over 12 months in a workplace cohort in Singapore. A total of 464 full-time employees (age = 21 years) were recruited fro... Read More about Risk Factors for Non-Communicable Diseases at Baseline and Their Short-Term Changes in a Workplace Cohort in Singapore.

Exercise treatment effect modifiers in persistent low back pain: an individual participant data meta-analysis of 3514 participants from 27 randomised controlled trials (2019)
Journal Article
(2019). Exercise treatment effect modifiers in persistent low back pain: an individual participant data meta-analysis of 3514 participants from 27 randomised controlled trials. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2019-101205

BACKGROUND: Low back pain is one of the leading causes of disability worldwide. Exercise therapy is widely recommended to treat persistent non-specific low back pain. While evidence suggests exercise is, on average, moderately effective, there remain... Read More about Exercise treatment effect modifiers in persistent low back pain: an individual participant data meta-analysis of 3514 participants from 27 randomised controlled trials.

Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. (2019)
Journal Article
Reynisson. (2019). Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. European Journal of Medicinal Chemistry, 111919 - ?. https://doi.org/10.1016/j.ejmech.2019.111919

Phosphatidylcholine-specific phospholipase C (PC-PLC) is a promising target for new anticancer treatment. Herein, we report our work in the discovery of novel drug-like PC-PLC inhibitors. Virtual screening led to the identification of promising hits... Read More about Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents..

Pharmacoepidemiology Research: delivering evidence about drug safety and effectiveness in mental health (2019)
Journal Article
Farooq. (2019). Pharmacoepidemiology Research: delivering evidence about drug safety and effectiveness in mental health. The Lancet Psychiatry, 363-370. https://doi.org/10.1016/S2215-0366%2819%2930298-6

There is a need for research that provides an evidence base for the pharmacotherapy of people with mental disorders. The abundance of digital data in recent years has facilitated pharmacoepidemiology in the form of observational comparative effective... Read More about Pharmacoepidemiology Research: delivering evidence about drug safety and effectiveness in mental health.